SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q58F21

- BRDT_HUMAN

UniProt

Q58F21 - BRDT_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bromodomain testis-specific protein

Gene
BRDT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Histone H4K5ac By similarity
Binding sitei109 – 1091JQ1 inhibitor
Binding sitei114 – 1141Histone H4K5ac By similarity

GO - Molecular functioni

  1. histone binding Source: UniProtKB
  2. lysine-acetylated histone binding Source: UniProtKB
  3. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. chromatin remodeling Source: UniProtKB
  3. histone displacement Source: UniProtKB
  4. male meiosis Source: UniProtKB
  5. male meiosis I Source: UniProtKB
  6. mRNA processing Source: UniProtKB-KW
  7. positive regulation of transcription during meiosis Source: UniProtKB
  8. regulation of RNA splicing Source: UniProtKB
  9. RNA splicing Source: UniProtKB-KW
  10. spermatogenesis Source: UniProtKB
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Differentiation, Meiosis, mRNA processing, mRNA splicing, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain testis-specific protein
Alternative name(s):
Cancer/testis antigen 9
Short name:
CT9
RING3-like protein
Gene namesi
Name:BRDT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1105. BRDT.

Subcellular locationi

Nucleus
Note: Detected on chromatin.3 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 947947Bromodomain testis-specific proteinPRO_0000239225Add
BLAST

Proteomic databases

MaxQBiQ58F21.
PaxDbiQ58F21.
PRIDEiQ58F21.

PTM databases

PhosphoSiteiQ58F21.

Expressioni

Tissue specificityi

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.3 Publications

Developmental stagei

Expressed in embryo testis.

Gene expression databases

ArrayExpressiQ58F21.
BgeeiQ58F21.
CleanExiHS_BRDT.
GenevestigatoriQ58F21.

Organism-specific databases

HPAiCAB012237.
HPA015283.

Interactioni

Subunit structurei

Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Interacts with SMARCE1 By similarity. Interacts with the acetylated N-terminus of histone H1.4, H2A, H2B, H3 and H4.1 Publication

Protein-protein interaction databases

BioGridi107143. 4 interactions.
IntActiQ58F21. 1 interaction.
STRINGi9606.ENSP00000354568.

Structurei

Secondary structure

1
947
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 378
Helixi39 – 446
Helixi47 – 526
Beta strandi53 – 553
Turni58 – 625
Helixi66 – 694
Helixi76 – 849
Helixi91 – 10818
Helixi114 – 13017

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RFJX-ray2.05A/B/C21-137[»]
4FLPX-ray2.23A/B21-137[»]
4KCXX-ray2.00A/B21-137[»]
ProteinModelPortaliQ58F21.
SMRiQ58F21. Positions 29-134, 266-377, 505-578.

Miscellaneous databases

EvolutionaryTraceiQ58F21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 11673Bromo 1Add
BLAST
Domaini287 – 35973Bromo 2Add
BLAST
Domaini500 – 58283NETAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili417 – 47054 Reviewed predictionAdd
BLAST
Coiled coili591 – 62131 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi209 – 22012Nuclear localization signal1 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi635 – 66733Ser-richAdd
BLAST

Domaini

Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions (1 Publication). Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) (1 Publication).1 Publication

Sequence similaritiesi

Contains 2 bromo domains.
Contains 1 NET domain.

Keywords - Domaini

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5076.
InParanoidiQ58F21.
KOiK11724.
OMAiENQRDLG.
OrthoDBiEOG7TTQ86.
PhylomeDBiQ58F21.
TreeFamiTF317345.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q58F21-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLPSRQTAI IVNPPPPEYI NTKKNGRLTN QLQYLQKVVL KDLWKHSFSW    50
PFQRPVDAVK LQLPDYYTII KNPMDLNTIK KRLENKYYAK ASECIEDFNT 100
MFSNCYLYNK PGDDIVLMAQ ALEKLFMQKL SQMPQEEQVV GVKERIKKGT 150
QQNIAVSSAK EKSSPSATEK VFKQQEIPSV FPKTSISPLN VVQGASVNSS 200
SQTAAQVTKG VKRKADTTTP ATSAVKASSE FSPTFTEKSV ALPPIKENMP 250
KNVLPDSQQQ YNVVKTVKVT EQLRHCSEIL KEMLAKKHFS YAWPFYNPVD 300
VNALGLHNYY DVVKNPMDLG TIKEKMDNQE YKDAYKFAAD VRLMFMNCYK 350
YNPPDHEVVT MARMLQDVFE THFSKIPIEP VESMPLCYIK TDITETTGRE 400
NTNEASSEGN SSDDSEDERV KRLAKLQEQL KAVHQQLQVL SQVPFRKLNK 450
KKEKSKKEKK KEKVNNSNEN PRKMCEQMRL KEKSKRNQPK KRKQQFIGLK 500
SEDEDNAKPM NYDEKRQLSL NINKLPGDKL GRVVHIIQSR EPSLSNSNPD 550
EIEIDFETLK ASTLRELEKY VSACLRKRPL KPPAKKIMMS KEELHSQKKQ 600
ELEKRLLDVN NQLNSRKRQT KSDKTQPSKA VENVSRLSES SSSSSSSSES 650
ESSSSDLSSS DSSDSESEMF PKFTEVKPND SPSKENVKKM KNECIPPEGR 700
TGVTQIGYCV QDTTSANTTL VHQTTPSHVM PPNHHQLAFN YQELEHLQTV 750
KNISPLQILP PSGDSEQLSN GITVMHPSGD SDTTMLESEC QAPVQKDIKI 800
KNADSWKSLG KPVKPSGVMK SSDELFNQFR KAAIEKEVKA RTQELIRKHL 850
EQNTKELKAS QENQRDLGNG LTVESFSNKI QNKCSGEEQK EHQQSSEAQD 900
KSKLWLLKDR DLARQKEQER RRREAMVGTI DMTLQSDIMT MFENNFD 947
Length:947
Mass (Da):107,954
Last modified:April 14, 2009 - v4
Checksum:i09C0FD8690E217BB
GO
Isoform 2 (identifier: Q58F21-2) [UniParc]FASTAAdd to Basket

Also known as: BRDT-NY

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTCTCRQDSKQLRM

Show »
Length:960
Mass (Da):109,506
Checksum:iD477F897F6D72935
GO
Isoform 3 (identifier: Q58F21-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-148: K → KGKAG

Show »
Length:951
Mass (Da):108,268
Checksum:i8A9508DF12C6AB36
GO
Isoform 4 (identifier: Q58F21-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-110: Missing.

Show »
Length:901
Mass (Da):102,361
Checksum:i64B19CBC80791B60
GO
Isoform 5 (identifier: Q58F21-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.

Show »
Length:874
Mass (Da):99,394
Checksum:iC8A7FAC55BA14F94
GO

Sequence cautioni

The sequence AAH05281.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH47900.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH62700.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → F.1 Publication
Corresponds to variant rs55806733 [ dbSNP | Ensembl ].
VAR_041924
Natural varianti6 – 61R → Q.1 Publication
Corresponds to variant rs56273490 [ dbSNP | Ensembl ].
VAR_041925
Natural varianti62 – 621Q → K.5 Publications
Corresponds to variant rs10783071 [ dbSNP | Ensembl ].
VAR_026584
Natural varianti89 – 891A → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041926
Natural varianti238 – 2381K → N.2 Publications
Corresponds to variant rs1156281 [ dbSNP | Ensembl ].
VAR_026585
Natural varianti288 – 2881H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_041927
Natural varianti336 – 3361K → T.
Corresponds to variant rs1064567 [ dbSNP | Ensembl ].
VAR_047327
Natural varianti357 – 3571E → K.1 Publication
Corresponds to variant rs34674879 [ dbSNP | Ensembl ].
VAR_041928
Natural varianti410 – 4101N → K.2 Publications
Corresponds to variant rs3088232 [ dbSNP | Ensembl ].
VAR_026586
Natural varianti542 – 5421P → A.1 Publication
Corresponds to variant rs55912588 [ dbSNP | Ensembl ].
VAR_041929
Natural varianti605 – 6051R → Q.
Corresponds to variant rs35327986 [ dbSNP | Ensembl ].
VAR_047328
Natural varianti696 – 6961P → L.4 Publications
Corresponds to variant rs10747493 [ dbSNP | Ensembl ].
VAR_047329

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 5. VSP_044509Add
BLAST
Alternative sequencei1 – 11M → MTCTCRQDSKQLRM in isoform 2. VSP_019118
Alternative sequencei65 – 11046Missing in isoform 4. VSP_044510Add
BLAST
Alternative sequencei148 – 1481K → KGKAG in isoform 3. VSP_044511

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421D → N in BAH13876. 1 Publication
Sequence conflicti73 – 731P → S in AAH05281. 1 Publication
Sequence conflicti80 – 801K → I in AAH62700. 1 Publication
Sequence conflicti265 – 2651K → E in AAB87862. 1 Publication
Sequence conflicti336 – 3361K → S in AAB87862. 1 Publication
Sequence conflicti462 – 4621E → K in AAH17582. 1 Publication
Sequence conflicti477 – 4771Q → R in BAH13876. 1 Publication
Sequence conflicti552 – 5521I → M in AAQ16198. 1 Publication
Sequence conflicti686 – 6861N → H in AAB87862. 1 Publication
Sequence conflicti893 – 8931Q → P in AAB87862. 1 Publication
Sequence conflicti915 – 9151Q → P in AAB87862. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019085 mRNA. Translation: AAB87862.1.
AY338951 mRNA. Translation: AAQ16198.1.
AK303008 mRNA. Translation: BAH13876.1.
AK302758 mRNA. Translation: BAH13797.1.
AK316442 mRNA. Translation: BAH14813.1.
AC114486 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73106.1.
CH471097 Genomic DNA. Translation: EAW73107.1.
CH471097 Genomic DNA. Translation: EAW73108.1.
CH471097 Genomic DNA. Translation: EAW73110.1.
CH471097 Genomic DNA. Translation: EAW73111.1.
BC005281 mRNA. Translation: AAH05281.1. Sequence problems.
BC017582 mRNA. Translation: AAH17582.1.
BC047900 mRNA. Translation: AAH47900.1. Sequence problems.
BC062700 mRNA. Translation: AAH62700.1. Sequence problems.
CCDSiCCDS55615.1. [Q58F21-4]
CCDS55616.1. [Q58F21-5]
CCDS735.1. [Q58F21-1]
RefSeqiNP_001229734.1. NM_001242805.1.
NP_001229735.1. NM_001242806.1.
NP_001229736.1. NM_001242807.1.
NP_001229737.1. NM_001242808.1.
NP_001229739.1. NM_001242810.1.
NP_001717.2. NM_001726.3.
NP_997072.1. NM_207189.2.
XP_005271208.1. XM_005271151.2. [Q58F21-1]
XP_006710916.1. XM_006710853.1. [Q58F21-1]
XP_006710917.1. XM_006710854.1. [Q58F21-1]
XP_006710918.1. XM_006710855.1. [Q58F21-1]
XP_006710919.1. XM_006710856.1. [Q58F21-1]
XP_006710920.1. XM_006710857.1. [Q58F21-1]
UniGeneiHs.482520.

Genome annotation databases

EnsembliENST00000362005; ENSP00000354568; ENSG00000137948. [Q58F21-1]
ENST00000370389; ENSP00000359416; ENSG00000137948. [Q58F21-5]
ENST00000394530; ENSP00000378038; ENSG00000137948. [Q58F21-4]
ENST00000399546; ENSP00000387822; ENSG00000137948. [Q58F21-1]
ENST00000402388; ENSP00000384051; ENSG00000137948. [Q58F21-1]
GeneIDi676.
KEGGihsa:676.
UCSCiuc001dok.4. human. [Q58F21-1]
uc010osz.2. human. [Q58F21-3]

Polymorphism databases

DMDMi226694198.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Asking life to be patient - Issue 144 of November 2012

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019085 mRNA. Translation: AAB87862.1 .
AY338951 mRNA. Translation: AAQ16198.1 .
AK303008 mRNA. Translation: BAH13876.1 .
AK302758 mRNA. Translation: BAH13797.1 .
AK316442 mRNA. Translation: BAH14813.1 .
AC114486 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73106.1 .
CH471097 Genomic DNA. Translation: EAW73107.1 .
CH471097 Genomic DNA. Translation: EAW73108.1 .
CH471097 Genomic DNA. Translation: EAW73110.1 .
CH471097 Genomic DNA. Translation: EAW73111.1 .
BC005281 mRNA. Translation: AAH05281.1 . Sequence problems.
BC017582 mRNA. Translation: AAH17582.1 .
BC047900 mRNA. Translation: AAH47900.1 . Sequence problems.
BC062700 mRNA. Translation: AAH62700.1 . Sequence problems.
CCDSi CCDS55615.1. [Q58F21-4 ]
CCDS55616.1. [Q58F21-5 ]
CCDS735.1. [Q58F21-1 ]
RefSeqi NP_001229734.1. NM_001242805.1.
NP_001229735.1. NM_001242806.1.
NP_001229736.1. NM_001242807.1.
NP_001229737.1. NM_001242808.1.
NP_001229739.1. NM_001242810.1.
NP_001717.2. NM_001726.3.
NP_997072.1. NM_207189.2.
XP_005271208.1. XM_005271151.2. [Q58F21-1 ]
XP_006710916.1. XM_006710853.1. [Q58F21-1 ]
XP_006710917.1. XM_006710854.1. [Q58F21-1 ]
XP_006710918.1. XM_006710855.1. [Q58F21-1 ]
XP_006710919.1. XM_006710856.1. [Q58F21-1 ]
XP_006710920.1. XM_006710857.1. [Q58F21-1 ]
UniGenei Hs.482520.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RFJ X-ray 2.05 A/B/C 21-137 [» ]
4FLP X-ray 2.23 A/B 21-137 [» ]
4KCX X-ray 2.00 A/B 21-137 [» ]
ProteinModelPortali Q58F21.
SMRi Q58F21. Positions 29-134, 266-377, 505-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107143. 4 interactions.
IntActi Q58F21. 1 interaction.
STRINGi 9606.ENSP00000354568.

Chemistry

ChEMBLi CHEMBL1795185.
GuidetoPHARMACOLOGYi 2729.

PTM databases

PhosphoSitei Q58F21.

Polymorphism databases

DMDMi 226694198.

Proteomic databases

MaxQBi Q58F21.
PaxDbi Q58F21.
PRIDEi Q58F21.

Protocols and materials databases

DNASUi 676.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000362005 ; ENSP00000354568 ; ENSG00000137948 . [Q58F21-1 ]
ENST00000370389 ; ENSP00000359416 ; ENSG00000137948 . [Q58F21-5 ]
ENST00000394530 ; ENSP00000378038 ; ENSG00000137948 . [Q58F21-4 ]
ENST00000399546 ; ENSP00000387822 ; ENSG00000137948 . [Q58F21-1 ]
ENST00000402388 ; ENSP00000384051 ; ENSG00000137948 . [Q58F21-1 ]
GeneIDi 676.
KEGGi hsa:676.
UCSCi uc001dok.4. human. [Q58F21-1 ]
uc010osz.2. human. [Q58F21-3 ]

Organism-specific databases

CTDi 676.
GeneCardsi GC01P092414.
HGNCi HGNC:1105. BRDT.
HPAi CAB012237.
HPA015283.
MIMi 602144. gene.
neXtProti NX_Q58F21.
PharmGKBi PA25418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
InParanoidi Q58F21.
KOi K11724.
OMAi ENQRDLG.
OrthoDBi EOG7TTQ86.
PhylomeDBi Q58F21.
TreeFami TF317345.

Miscellaneous databases

ChiTaRSi BRDT. human.
EvolutionaryTracei Q58F21.
GeneWikii BRDT.
GenomeRNAii 676.
NextBioi 2784.
PROi Q58F21.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q58F21.
Bgeei Q58F21.
CleanExi HS_BRDT.
Genevestigatori Q58F21.

Family and domain databases

Gene3Di 1.20.920.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh."
    Jones M.H., Numata M., Shimane M.
    Genomics 45:529-534(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS LYS-62 AND LEU-696.
  2. "Molecular cloning and expression of a novel alternative splice variant of BRDT gene."
    Zheng Y., Yuan W., Zhou Z., Xu M., Sha J.-H.
    Int. J. Mol. Med. 15:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANTS LYS-62 AND LEU-696.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS LYS-62 AND LEU-696.
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LYS-62 AND LEU-696.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-462 (ISOFORM 1), VARIANTS LYS-62; ASN-238 AND LYS-410.
    Tissue: Brain and Testis.
  7. "Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9."
    Scanlan M.J., Altorki N.K., Gure A.O., Williamson B., Jungbluth A., Chen Y.-T., Old L.J.
    Cancer Lett. 150:155-164(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-2; GLN-6; VAL-89; ASN-238; TYR-288; LYS-357; LYS-410 AND ALA-542.
  9. "The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men."
    Steilmann C., Cavalcanti M.C., Bartkuhn M., Pons-Kuhnemann J., Schuppe H.C., Weidner W., Steger K., Paradowska A.
    Reproduction 140:435-443(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "The conserved 12-amino acid stretch in the inter-bromodomain region of BET family proteins functions as a nuclear localization signal."
    Fukazawa H., Masumi A.
    Biol. Pharm. Bull. 35:2064-2068(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MOTIF NUCLEAR LOCALIZATION SIGNAL.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 21-137, SUBUNIT, DOMAIN.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 21-137 IN COMPLEX WITH JQ1, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiBRDT_HUMAN
AccessioniPrimary (citable) accession number: Q58F21
Secondary accession number(s): A6NF68
, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q6P5T1, Q7Z4A6, Q8IWI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 14, 2009
Last modified: September 3, 2014
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect in male mice (1 Publication).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi