Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bromodomain testis-specific protein

Gene

BRDT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Histone H4K5acBy similarity1
Binding sitei109JQ1 inhibitor1 Publication1
Binding sitei114Histone H4K5acBy similarity1

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • lysine-acetylated histone binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Differentiation, Meiosis, mRNA processing, mRNA splicing, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain testis-specific protein
Alternative name(s):
Cancer/testis antigen 9
Short name:
CT9
RING3-like protein
Gene namesi
Name:BRDT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1105. BRDT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi676.
OpenTargetsiENSG00000137948.
PharmGKBiPA25418.

Chemistry databases

ChEMBLiCHEMBL1795185.
GuidetoPHARMACOLOGYi2729.

Polymorphism and mutation databases

BioMutaiBRDT.
DMDMi226694198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392251 – 947Bromodomain testis-specific proteinAdd BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ58F21.
MaxQBiQ58F21.
PaxDbiQ58F21.
PeptideAtlasiQ58F21.
PRIDEiQ58F21.

PTM databases

iPTMnetiQ58F21.
PhosphoSitePlusiQ58F21.

Expressioni

Tissue specificityi

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.3 Publications

Developmental stagei

Expressed in embryo testis.

Gene expression databases

BgeeiENSG00000137948.
CleanExiHS_BRDT.
ExpressionAtlasiQ58F21. baseline and differential.
GenevisibleiQ58F21. HS.

Organism-specific databases

HPAiCAB012237.
HPA015283.

Interactioni

Subunit structurei

Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Interacts with SMARCE1 (By similarity). Interacts with the acetylated N-terminus of histone H1.4, H2A, H2B, H3 and H4.By similarity2 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • lysine-acetylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107143. 5 interactors.
IntActiQ58F21. 1 interactor.
STRINGi9606.ENSP00000354568.

Chemistry databases

BindingDBiQ58F21.

Structurei

Secondary structure

1947
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 37Combined sources8
Helixi39 – 44Combined sources6
Helixi47 – 52Combined sources6
Beta strandi53 – 55Combined sources3
Turni58 – 62Combined sources5
Helixi66 – 69Combined sources4
Helixi76 – 84Combined sources9
Helixi91 – 108Combined sources18
Helixi114 – 130Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RFJX-ray2.05A/B/C21-137[»]
4FLPX-ray2.23A/B21-137[»]
4KCXX-ray2.00A/B21-137[»]
ProteinModelPortaliQ58F21.
SMRiQ58F21.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58F21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 116Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini287 – 359Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini500 – 582NETPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili417 – 470Sequence analysisAdd BLAST54
Coiled coili591 – 621Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi209 – 220Nuclear localization signalAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi635 – 667Ser-richAdd BLAST33

Domaini

Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) (PubMed:22901802).2 Publications

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 1 NET domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
InParanoidiQ58F21.
KOiK11724.
OMAiENQRDLG.
OrthoDBiEOG091G01QC.
PhylomeDBiQ58F21.
TreeFamiTF317345.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58F21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLPSRQTAI IVNPPPPEYI NTKKNGRLTN QLQYLQKVVL KDLWKHSFSW
60 70 80 90 100
PFQRPVDAVK LQLPDYYTII KNPMDLNTIK KRLENKYYAK ASECIEDFNT
110 120 130 140 150
MFSNCYLYNK PGDDIVLMAQ ALEKLFMQKL SQMPQEEQVV GVKERIKKGT
160 170 180 190 200
QQNIAVSSAK EKSSPSATEK VFKQQEIPSV FPKTSISPLN VVQGASVNSS
210 220 230 240 250
SQTAAQVTKG VKRKADTTTP ATSAVKASSE FSPTFTEKSV ALPPIKENMP
260 270 280 290 300
KNVLPDSQQQ YNVVKTVKVT EQLRHCSEIL KEMLAKKHFS YAWPFYNPVD
310 320 330 340 350
VNALGLHNYY DVVKNPMDLG TIKEKMDNQE YKDAYKFAAD VRLMFMNCYK
360 370 380 390 400
YNPPDHEVVT MARMLQDVFE THFSKIPIEP VESMPLCYIK TDITETTGRE
410 420 430 440 450
NTNEASSEGN SSDDSEDERV KRLAKLQEQL KAVHQQLQVL SQVPFRKLNK
460 470 480 490 500
KKEKSKKEKK KEKVNNSNEN PRKMCEQMRL KEKSKRNQPK KRKQQFIGLK
510 520 530 540 550
SEDEDNAKPM NYDEKRQLSL NINKLPGDKL GRVVHIIQSR EPSLSNSNPD
560 570 580 590 600
EIEIDFETLK ASTLRELEKY VSACLRKRPL KPPAKKIMMS KEELHSQKKQ
610 620 630 640 650
ELEKRLLDVN NQLNSRKRQT KSDKTQPSKA VENVSRLSES SSSSSSSSES
660 670 680 690 700
ESSSSDLSSS DSSDSESEMF PKFTEVKPND SPSKENVKKM KNECIPPEGR
710 720 730 740 750
TGVTQIGYCV QDTTSANTTL VHQTTPSHVM PPNHHQLAFN YQELEHLQTV
760 770 780 790 800
KNISPLQILP PSGDSEQLSN GITVMHPSGD SDTTMLESEC QAPVQKDIKI
810 820 830 840 850
KNADSWKSLG KPVKPSGVMK SSDELFNQFR KAAIEKEVKA RTQELIRKHL
860 870 880 890 900
EQNTKELKAS QENQRDLGNG LTVESFSNKI QNKCSGEEQK EHQQSSEAQD
910 920 930 940
KSKLWLLKDR DLARQKEQER RRREAMVGTI DMTLQSDIMT MFENNFD
Length:947
Mass (Da):107,954
Last modified:April 14, 2009 - v4
Checksum:i09C0FD8690E217BB
GO
Isoform 2 (identifier: Q58F21-2) [UniParc]FASTAAdd to basket
Also known as: BRDT-NY

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTCTCRQDSKQLRM

Show »
Length:960
Mass (Da):109,506
Checksum:iD477F897F6D72935
GO
Isoform 3 (identifier: Q58F21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-148: K → KGKAG

Show »
Length:951
Mass (Da):108,268
Checksum:i8A9508DF12C6AB36
GO
Isoform 4 (identifier: Q58F21-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-110: Missing.

Show »
Length:901
Mass (Da):102,361
Checksum:i64B19CBC80791B60
GO
Isoform 5 (identifier: Q58F21-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:874
Mass (Da):99,394
Checksum:iC8A7FAC55BA14F94
GO

Sequence cautioni

The sequence AAH05281 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH47900 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH62700 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42D → N in BAH13876 (PubMed:14702039).Curated1
Sequence conflicti73P → S in AAH05281 (PubMed:15489334).Curated1
Sequence conflicti80K → I in AAH62700 (PubMed:15489334).Curated1
Sequence conflicti265K → E in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti336K → S in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti462E → K in AAH17582 (PubMed:15489334).Curated1
Sequence conflicti477Q → R in BAH13876 (PubMed:14702039).Curated1
Sequence conflicti552I → M in AAQ16198 (PubMed:15647849).Curated1
Sequence conflicti686N → H in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti893Q → P in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti915Q → P in AAB87862 (PubMed:9367677).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0419242S → F.1 PublicationCorresponds to variant rs55806733dbSNPEnsembl.1
Natural variantiVAR_0419256R → Q.1 PublicationCorresponds to variant rs56273490dbSNPEnsembl.1
Natural variantiVAR_02658462Q → K.5 PublicationsCorresponds to variant rs10783071dbSNPEnsembl.1
Natural variantiVAR_04192689A → V in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs781375003dbSNPEnsembl.1
Natural variantiVAR_026585238K → N.2 PublicationsCorresponds to variant rs1156281dbSNPEnsembl.1
Natural variantiVAR_041927288H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_047327336K → T.Corresponds to variant rs1064567dbSNPEnsembl.1
Natural variantiVAR_041928357E → K.1 PublicationCorresponds to variant rs34674879dbSNPEnsembl.1
Natural variantiVAR_026586410N → K.2 PublicationsCorresponds to variant rs3088232dbSNPEnsembl.1
Natural variantiVAR_041929542P → A.1 PublicationCorresponds to variant rs55912588dbSNPEnsembl.1
Natural variantiVAR_047328605R → Q.Corresponds to variant rs35327986dbSNPEnsembl.1
Natural variantiVAR_047329696P → L.4 PublicationsCorresponds to variant rs10747493dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445091 – 73Missing in isoform 5. CuratedAdd BLAST73
Alternative sequenceiVSP_0191181M → MTCTCRQDSKQLRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_04451065 – 110Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_044511148K → KGKAG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019085 mRNA. Translation: AAB87862.1.
AY338951 mRNA. Translation: AAQ16198.1.
AK303008 mRNA. Translation: BAH13876.1.
AK302758 mRNA. Translation: BAH13797.1.
AK316442 mRNA. Translation: BAH14813.1.
AC114486 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73106.1.
CH471097 Genomic DNA. Translation: EAW73107.1.
CH471097 Genomic DNA. Translation: EAW73108.1.
CH471097 Genomic DNA. Translation: EAW73110.1.
CH471097 Genomic DNA. Translation: EAW73111.1.
BC005281 mRNA. Translation: AAH05281.1. Sequence problems.
BC017582 mRNA. Translation: AAH17582.1.
BC047900 mRNA. Translation: AAH47900.1. Sequence problems.
BC062700 mRNA. Translation: AAH62700.1. Sequence problems.
CCDSiCCDS55615.1. [Q58F21-4]
CCDS55616.1. [Q58F21-5]
CCDS72820.1. [Q58F21-3]
CCDS735.1. [Q58F21-1]
RefSeqiNP_001229734.2. NM_001242805.2. [Q58F21-1]
NP_001229735.2. NM_001242806.2. [Q58F21-3]
NP_001229736.2. NM_001242807.2. [Q58F21-4]
NP_001229737.2. NM_001242808.2. [Q58F21-4]
NP_001229739.2. NM_001242810.2. [Q58F21-5]
NP_001717.3. NM_001726.4. [Q58F21-1]
NP_997072.2. NM_207189.3. [Q58F21-1]
XP_006710916.1. XM_006710853.3. [Q58F21-1]
XP_006710917.1. XM_006710854.3. [Q58F21-1]
XP_006710918.1. XM_006710855.3. [Q58F21-1]
XP_006710919.1. XM_006710856.3. [Q58F21-1]
XP_006710920.1. XM_006710857.3. [Q58F21-1]
XP_011540334.1. XM_011542032.2. [Q58F21-1]
XP_011540335.1. XM_011542033.2. [Q58F21-1]
XP_011540336.1. XM_011542034.2. [Q58F21-1]
XP_011540337.1. XM_011542035.2. [Q58F21-1]
XP_011540338.1. XM_011542036.2. [Q58F21-1]
UniGeneiHs.482520.

Genome annotation databases

EnsembliENST00000362005; ENSP00000354568; ENSG00000137948. [Q58F21-1]
ENST00000370389; ENSP00000359416; ENSG00000137948. [Q58F21-5]
ENST00000394530; ENSP00000378038; ENSG00000137948. [Q58F21-4]
ENST00000399546; ENSP00000387822; ENSG00000137948. [Q58F21-3]
ENST00000402388; ENSP00000384051; ENSG00000137948. [Q58F21-1]
GeneIDi676.
KEGGihsa:676.
UCSCiuc001dol.5. human. [Q58F21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Asking life to be patient - Issue 144 of November 2012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019085 mRNA. Translation: AAB87862.1.
AY338951 mRNA. Translation: AAQ16198.1.
AK303008 mRNA. Translation: BAH13876.1.
AK302758 mRNA. Translation: BAH13797.1.
AK316442 mRNA. Translation: BAH14813.1.
AC114486 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73106.1.
CH471097 Genomic DNA. Translation: EAW73107.1.
CH471097 Genomic DNA. Translation: EAW73108.1.
CH471097 Genomic DNA. Translation: EAW73110.1.
CH471097 Genomic DNA. Translation: EAW73111.1.
BC005281 mRNA. Translation: AAH05281.1. Sequence problems.
BC017582 mRNA. Translation: AAH17582.1.
BC047900 mRNA. Translation: AAH47900.1. Sequence problems.
BC062700 mRNA. Translation: AAH62700.1. Sequence problems.
CCDSiCCDS55615.1. [Q58F21-4]
CCDS55616.1. [Q58F21-5]
CCDS72820.1. [Q58F21-3]
CCDS735.1. [Q58F21-1]
RefSeqiNP_001229734.2. NM_001242805.2. [Q58F21-1]
NP_001229735.2. NM_001242806.2. [Q58F21-3]
NP_001229736.2. NM_001242807.2. [Q58F21-4]
NP_001229737.2. NM_001242808.2. [Q58F21-4]
NP_001229739.2. NM_001242810.2. [Q58F21-5]
NP_001717.3. NM_001726.4. [Q58F21-1]
NP_997072.2. NM_207189.3. [Q58F21-1]
XP_006710916.1. XM_006710853.3. [Q58F21-1]
XP_006710917.1. XM_006710854.3. [Q58F21-1]
XP_006710918.1. XM_006710855.3. [Q58F21-1]
XP_006710919.1. XM_006710856.3. [Q58F21-1]
XP_006710920.1. XM_006710857.3. [Q58F21-1]
XP_011540334.1. XM_011542032.2. [Q58F21-1]
XP_011540335.1. XM_011542033.2. [Q58F21-1]
XP_011540336.1. XM_011542034.2. [Q58F21-1]
XP_011540337.1. XM_011542035.2. [Q58F21-1]
XP_011540338.1. XM_011542036.2. [Q58F21-1]
UniGeneiHs.482520.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RFJX-ray2.05A/B/C21-137[»]
4FLPX-ray2.23A/B21-137[»]
4KCXX-ray2.00A/B21-137[»]
ProteinModelPortaliQ58F21.
SMRiQ58F21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107143. 5 interactors.
IntActiQ58F21. 1 interactor.
STRINGi9606.ENSP00000354568.

Chemistry databases

BindingDBiQ58F21.
ChEMBLiCHEMBL1795185.
GuidetoPHARMACOLOGYi2729.

PTM databases

iPTMnetiQ58F21.
PhosphoSitePlusiQ58F21.

Polymorphism and mutation databases

BioMutaiBRDT.
DMDMi226694198.

Proteomic databases

EPDiQ58F21.
MaxQBiQ58F21.
PaxDbiQ58F21.
PeptideAtlasiQ58F21.
PRIDEiQ58F21.

Protocols and materials databases

DNASUi676.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362005; ENSP00000354568; ENSG00000137948. [Q58F21-1]
ENST00000370389; ENSP00000359416; ENSG00000137948. [Q58F21-5]
ENST00000394530; ENSP00000378038; ENSG00000137948. [Q58F21-4]
ENST00000399546; ENSP00000387822; ENSG00000137948. [Q58F21-3]
ENST00000402388; ENSP00000384051; ENSG00000137948. [Q58F21-1]
GeneIDi676.
KEGGihsa:676.
UCSCiuc001dol.5. human. [Q58F21-1]

Organism-specific databases

CTDi676.
DisGeNETi676.
GeneCardsiBRDT.
HGNCiHGNC:1105. BRDT.
HPAiCAB012237.
HPA015283.
MIMi602144. gene.
neXtProtiNX_Q58F21.
OpenTargetsiENSG00000137948.
PharmGKBiPA25418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1474. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000231200.
InParanoidiQ58F21.
KOiK11724.
OMAiENQRDLG.
OrthoDBiEOG091G01QC.
PhylomeDBiQ58F21.
TreeFamiTF317345.

Miscellaneous databases

ChiTaRSiBRDT. human.
EvolutionaryTraceiQ58F21.
GeneWikiiBRDT.
GenomeRNAii676.
PROiQ58F21.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137948.
CleanExiHS_BRDT.
ExpressionAtlasiQ58F21. baseline and differential.
GenevisibleiQ58F21. HS.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR031354. BRD4_CDT.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamiPF17035. BET. 1 hit.
PF17105. BRD4_CDT. 1 hit.
PF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRDT_HUMAN
AccessioniPrimary (citable) accession number: Q58F21
Secondary accession number(s): A6NF68
, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q6P5T1, Q7Z4A6, Q8IWI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 14, 2009
Last modified: November 2, 2016
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect in male mice (PubMed:22901802).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.