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Protein
Submitted name:

RAR-related orphan receptor B

Gene

RORB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 82Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RAR-related orphan receptor BImported
Submitted name:
RAR-related orphan receptor betaImported
Submitted name:
cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNAImported
Gene namesi
Name:RORBImported
Synonyms:NR1F2Imported
ORF Names:hCG_27313Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34631.

Expressioni

Gene expression databases

BgeeiENSG00000198963.
ExpressionAtlasiQ58EY0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366093.

Structurei

3D structure databases

SMRiQ58EY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 82Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 114Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
HOVERGENiHBG106848.
KOiK08533.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58EY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR
60 70 80 90 100
NCLIDRTNRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH
110 120 130 140 150
QQRLQEQRQQ QSGEAEALAR VYSSSISNGL SNLNNETSGT YANGHVIDLP
160 170 180 190 200
KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ EPIYDLTSVP NLFTYSSFNN
210 220 230 240 250
GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELHQLAWQ THTYEEIKAY
260 270 280 290 300
QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL
310 320 330 340 350
EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC
360 370 380 390 400
SLQLTEEEIA LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH
410 420 430 440 450
LDDETLAKLI AKIPTITAVC NLHGEKLQVF KQSHPEIVNT LFPPLYKELF

NPDCATGCK
Length:459
Mass (Da):52,073
Last modified:February 5, 2008 - v1
Checksum:iE15FD91422CCD67C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051830 mRNA. Translation: AAH51830.1.
BC093772 mRNA. Translation: AAH93772.1.
BC093774 mRNA. Translation: AAH93774.1.
HQ709186 mRNA. Translation: ADZ17393.1.
AK313431 mRNA. Translation: BAG36222.1.
CH471089 Genomic DNA. Translation: EAW62552.1.
RefSeqiNP_008845.2. NM_006914.3.
UniGeneiHs.494178.

Genome annotation databases

GeneIDi6096.
KEGGihsa:6096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051830 mRNA. Translation: AAH51830.1.
BC093772 mRNA. Translation: AAH93772.1.
BC093774 mRNA. Translation: AAH93774.1.
HQ709186 mRNA. Translation: ADZ17393.1.
AK313431 mRNA. Translation: BAG36222.1.
CH471089 Genomic DNA. Translation: EAW62552.1.
RefSeqiNP_008845.2. NM_006914.3.
UniGeneiHs.494178.

3D structure databases

SMRiQ58EY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366093.

Protocols and materials databases

DNASUi6096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6096.
KEGGihsa:6096.

Organism-specific databases

CTDi6096.
PharmGKBiPA34631.

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
HOVERGENiHBG106848.
KOiK08533.

Miscellaneous databases

ChiTaRSiRORB. human.
GenomeRNAii6096.

Gene expression databases

BgeeiENSG00000198963.
ExpressionAtlasiQ58EY0. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ58EY0_HUMAN
AccessioniPrimary (citable) accession number: Q58EY0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.