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Protein
Submitted name:

RAR related orphan receptor B isoform 1

Gene

RORB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 82Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RAR related orphan receptor B isoform 1Imported
Submitted name:
RAR-related orphan receptor BImported
Submitted name:
RAR-related orphan receptor betaImported
Submitted name:
cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNAImported
Gene namesi
Name:RORBImported
Synonyms:NR1F2Imported, ROR-BETAImported, RZRBImported
ORF Names:hCG_27313Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198963.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34631

Expressioni

Gene expression databases

BgeeiENSG00000198963

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 82Nuclear receptorInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 114Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4216 Eukaryota
ENOG410XUGR LUCA
HOVERGENiHBG106848
KOiK08533

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003079 ROR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01293 RORNUCRECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58EY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR
60 70 80 90 100
NCLIDRTNRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH
110 120 130 140 150
QQRLQEQRQQ QSGEAEALAR VYSSSISNGL SNLNNETSGT YANGHVIDLP
160 170 180 190 200
KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ EPIYDLTSVP NLFTYSSFNN
210 220 230 240 250
GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELHQLAWQ THTYEEIKAY
260 270 280 290 300
QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL
310 320 330 340 350
EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC
360 370 380 390 400
SLQLTEEEIA LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH
410 420 430 440 450
LDDETLAKLI AKIPTITAVC NLHGEKLQVF KQSHPEIVNT LFPPLYKELF

NPDCATGCK
Length:459
Mass (Da):52,073
Last modified:February 5, 2008 - v1
Checksum:iE15FD91422CCD67C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051830 mRNA Translation: AAH51830.1
BC093772 mRNA Translation: AAH93772.1
BC093774 mRNA Translation: AAH93774.1
HQ709186 mRNA Translation: ADZ17393.1
KY037793 mRNA Translation: APJ36117.1
AK313431 mRNA Translation: BAG36222.1
CH471089 Genomic DNA Translation: EAW62552.1
RefSeqiNP_008845.2, NM_006914.3
UniGeneiHs.494178

Genome annotation databases

GeneIDi6096
KEGGihsa:6096

Similar proteinsi

Entry informationi

Entry nameiQ58EY0_HUMAN
AccessioniPrimary (citable) accession number: Q58EY0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health