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Protein

Protein sidekick-2

Gene

SDK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sidekick-2By similarity
Gene namesi
Name:SDK2By similarityImported
Synonyms:KIAA15141 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19308. SDK2.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Cell junctionsynapse By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 19321912ExtracellularSequence analysisAdd
BLAST
Transmembranei1933 – 195321HelicalSequence analysisAdd
BLAST
Topological domaini1954 – 2172219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981456.

Polymorphism and mutation databases

BioMutaiSDK2.
DMDMi296452966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 21722152Protein sidekick-2PRO_0000226978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 91PROSITE-ProRule annotation
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi237 ↔ 284PROSITE-ProRule annotation
Disulfide bondi330 ↔ 380PROSITE-ProRule annotation
Disulfide bondi423 ↔ 475PROSITE-ProRule annotation
Disulfide bondi517 ↔ 569PROSITE-ProRule annotation
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence analysis
Glycosylationi743 – 7431N-linked (GlcNAc...)Sequence analysis
Glycosylationi936 – 9361N-linked (GlcNAc...)Sequence analysis
Glycosylationi948 – 9481N-linked (GlcNAc...)Sequence analysis
Glycosylationi1102 – 11021N-linked (GlcNAc...)Sequence analysis
Glycosylationi1670 – 16701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ58EX2.
MaxQBiQ58EX2.
PaxDbiQ58EX2.
PRIDEiQ58EX2.

PTM databases

iPTMnetiQ58EX2.
PhosphoSiteiQ58EX2.

Expressioni

Gene expression databases

BgeeiQ58EX2.
CleanExiHS_SDK2.
ExpressionAtlasiQ58EX2. baseline and differential.
GenevisibleiQ58EX2. HS.

Organism-specific databases

HPAiHPA014725.

Interactioni

Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.By similarity

Protein-protein interaction databases

BioGridi120034. 11 interactions.
IntActiQ58EX2. 1 interaction.
STRINGi9606.ENSP00000376421.

Structurei

Secondary structure

1
2172
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi597 – 6004Combined sources
Beta strandi602 – 6043Combined sources
Beta strandi607 – 6115Combined sources
Beta strandi622 – 6309Combined sources
Beta strandi637 – 6426Combined sources
Beta strandi649 – 6546Combined sources
Beta strandi660 – 67112Combined sources
Beta strandi673 – 6764Combined sources
Beta strandi902 – 9054Combined sources
Beta strandi908 – 9147Combined sources
Beta strandi927 – 93610Combined sources
Helixi938 – 9403Combined sources
Beta strandi944 – 9463Combined sources
Beta strandi952 – 9576Combined sources
Beta strandi963 – 9719Combined sources
Beta strandi976 – 98510Combined sources
Beta strandi997 – 10037Combined sources
Beta strandi1009 – 10146Combined sources
Beta strandi1024 – 10307Combined sources
Beta strandi1042 – 10498Combined sources
Beta strandi1054 – 10585Combined sources
Beta strandi1065 – 10673Combined sources
Beta strandi1072 – 10743Combined sources
Beta strandi1308 – 13125Combined sources
Beta strandi1314 – 13207Combined sources
Beta strandi1333 – 134210Combined sources
Beta strandi1350 – 13534Combined sources
Beta strandi1359 – 13646Combined sources
Beta strandi1367 – 137812Combined sources
Beta strandi1383 – 139210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WF5NMR-A580-687[»]
1WFNNMR-A885-990[»]
1WFONMR-A1281-1397[»]
1WISNMR-A983-1093[»]
ProteinModelPortaliQ58EX2.
SMRiQ58EX2. Positions 582-692, 878-1096, 1287-1400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58EX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10883Ig-like C2-type 1Add
BLAST
Domaini113 – 20088Ig-like C2-type 2Add
BLAST
Domaini215 – 29480Ig-like C2-type 3Add
BLAST
Domaini308 – 39689Ig-like C2-type 4Add
BLAST
Domaini402 – 49190Ig-like C2-type 5Add
BLAST
Domaini496 – 58590Ig-like C2-type 6Add
BLAST
Domaini592 – 68897Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini693 – 78997Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini794 – 893100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini897 – 99195Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini995 – 1094100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini1099 – 119799Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini1202 – 129998Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1303 – 139795Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1402 – 149998Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini1504 – 1621118Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1626 – 172297Fibronectin type-III 11PROSITE-ProRule annotationAdd
BLAST
Domaini1726 – 182196Fibronectin type-III 12PROSITE-ProRule annotationAdd
BLAST
Domaini1824 – 1923100Fibronectin type-III 13PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2166 – 21727PDZ-bindingBy similarity

Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.By similarity

Sequence similaritiesi

Belongs to the sidekick family.Curated
Contains 13 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJJ. Eukaryota.
ENOG410YMNG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG080083.
InParanoidiQ58EX2.
KOiK16353.
OMAiNRERPQA.
OrthoDBiEOG7MPRCZ.
PhylomeDBiQ58EX2.
TreeFamiTF316846.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 13 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 13 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 7 hits.
PROSITEiPS50853. FN3. 13 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA
60 70 80 90 100
EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL
110 120 130 140 150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD
160 170 180 190 200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT
210 220 230 240 250
LTVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII
260 270 280 290 300
WKKDGVLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA
310 320 330 340 350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC QAKGVPPPSI TWYKDAAVVE
360 370 380 390 400
VEKLTRFRQR NDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI
410 420 430 440 450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP
460 470 480 490 500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK
510 520 530 540 550
PPQDQSVIKG TQASMVCGVT HDPRVTIRYI WEKDGATLGT ESHPRIRLDR
560 570 580 590 600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL
610 620 630 640 650
STVERRAINL TWTKPFDGNS PLIRYILEMS ENNAPWTVLL ASVDPKATSV
660 670 680 690 700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS
710 720 730 740 750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN
760 770 780 790 800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA
810 820 830 840 850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ
860 870 880 890 900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSTPQLVRT HEDVPGPVGH
910 920 930 940 950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT
960 970 980 990 1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG
1010 1020 1030 1040 1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE
1060 1070 1080 1090 1100
PDARSMEVPD LNPFTCYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP
1110 1120 1130 1140 1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH
1160 1170 1180 1190 1200
VVQDRVERDY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS
1210 1220 1230 1240 1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVMYK EKDSDTQPRF
1260 1270 1280 1290 1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV
1310 1320 1330 1340 1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV
1360 1370 1380 1390 1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGEAAEAL VVTTEKRDRP
1410 1420 1430 1440 1450
QPPSRPMVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWALH
1460 1470 1480 1490 1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA
1510 1520 1530 1540 1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR
1560 1570 1580 1590 1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS
1610 1620 1630 1640 1650
VYNAVGEGPS SPPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD
1660 1670 1680 1690 1700
SQNGDIQGYK IYFWEAQRGN LTERVKTLFL AENSVKLKNL TGYTAYMVSV
1710 1720 1730 1740 1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP
1760 1770 1780 1790 1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR
1810 1820 1830 1840 1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG
1860 1870 1880 1890 1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV
1910 1920 1930 1940 1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV
1960 1970 1980 1990 2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV
2010 2020 2030 2040 2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE
2060 2070 2080 2090 2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY
2110 2120 2130 2140 2150
SYTESDSGEP DHTTVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL
2160 2170
YRPPSSLAPG SRAPIAGFSS FV
Length:2,172
Mass (Da):239,396
Last modified:May 18, 2010 - v3
Checksum:i3CAF9FE659C72A03
GO
Isoform 2 (identifier: Q58EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1865-1921: DEGLWDILIK...SSPSQSVPAQ → GAPRPAGLRP...EEWETGLGGS
     1922-2172: Missing.

Note: No experimental confirmation available.
Show »
Length:1,921
Mass (Da):211,180
Checksum:i1788A7BE49FA74D4
GO
Isoform 3 (identifier: Q58EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1588: SMYSMRNLSRPSLTQYELDN → Y

Note: No experimental confirmation available.
Show »
Length:2,153
Mass (Da):237,172
Checksum:iCC6B77234A0DF50A
GO
Isoform 4 (identifier: Q58EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2172: SLAPGSRAPIAGFSSFV → KAGVQKEGEN...GIWRERGSGG

Note: No experimental confirmation available.
Show »
Length:2,216
Mass (Da):244,370
Checksum:i0D3DD65A6908A0D5
GO

Sequence cautioni

The sequence BAA91841.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1218 – 12181V → G in CAB70709 (PubMed:17974005).Curated
Sequence conflicti1382 – 13821G → V in CAB70709 (PubMed:17974005).Curated
Sequence conflicti1553 – 15531T → M in AAH45763 (PubMed:15489334).Curated
Sequence conflicti1553 – 15531T → M in AAH66363 (PubMed:15489334).Curated
Sequence conflicti1680 – 16801L → P in BAA91841 (PubMed:14702039).Curated
Sequence conflicti2092 – 20921K → R in BAA91841 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1569 – 158820SMYSM…YELDN → Y in isoform 3. 1 PublicationVSP_017522Add
BLAST
Alternative sequencei1865 – 192157DEGLW…SVPAQ → GAPRPAGLRPHSSLSPFFLG PSTWGTCLCPPPEKALVLLQ VKSPGPVEEWETGLGGS in isoform 2. 1 PublicationVSP_017523Add
BLAST
Alternative sequencei1922 – 2172251Missing in isoform 2. 1 PublicationVSP_017524Add
BLAST
Alternative sequencei2156 – 217217SLAPG…FSSFV → KAGVQKEGENRERMCVASSS SALRWWGSLLPWELHGAGEV AVSLLWTRSGPGIWRERGSG G in isoform 4. 1 PublicationVSP_017525Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC032019 Genomic DNA. No translation available.
AC087301 Genomic DNA. No translation available.
AC124804 Genomic DNA. No translation available.
AB040947 mRNA. Translation: BAA96038.1.
BC045763 mRNA. Translation: AAH45763.1.
BC066363 mRNA. Translation: AAH66363.1.
AL137357 mRNA. Translation: CAB70709.1.
AK001694 mRNA. Translation: BAA91841.1. Different initiation.
CCDSiCCDS45769.1. [Q58EX2-1]
PIRiT46428.
RefSeqiNP_001138424.1. NM_001144952.1. [Q58EX2-1]
XP_011523216.1. XM_011524914.1. [Q58EX2-3]
UniGeneiHs.435719.

Genome annotation databases

EnsembliENST00000392650; ENSP00000376421; ENSG00000069188. [Q58EX2-1]
GeneIDi54549.
KEGGihsa:54549.
UCSCiuc010dfm.4. human. [Q58EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Discerning change - Issue 176 of February 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC032019 Genomic DNA. No translation available.
AC087301 Genomic DNA. No translation available.
AC124804 Genomic DNA. No translation available.
AB040947 mRNA. Translation: BAA96038.1.
BC045763 mRNA. Translation: AAH45763.1.
BC066363 mRNA. Translation: AAH66363.1.
AL137357 mRNA. Translation: CAB70709.1.
AK001694 mRNA. Translation: BAA91841.1. Different initiation.
CCDSiCCDS45769.1. [Q58EX2-1]
PIRiT46428.
RefSeqiNP_001138424.1. NM_001144952.1. [Q58EX2-1]
XP_011523216.1. XM_011524914.1. [Q58EX2-3]
UniGeneiHs.435719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WF5NMR-A580-687[»]
1WFNNMR-A885-990[»]
1WFONMR-A1281-1397[»]
1WISNMR-A983-1093[»]
ProteinModelPortaliQ58EX2.
SMRiQ58EX2. Positions 582-692, 878-1096, 1287-1400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120034. 11 interactions.
IntActiQ58EX2. 1 interaction.
STRINGi9606.ENSP00000376421.

PTM databases

iPTMnetiQ58EX2.
PhosphoSiteiQ58EX2.

Polymorphism and mutation databases

BioMutaiSDK2.
DMDMi296452966.

Proteomic databases

EPDiQ58EX2.
MaxQBiQ58EX2.
PaxDbiQ58EX2.
PRIDEiQ58EX2.

Protocols and materials databases

DNASUi54549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392650; ENSP00000376421; ENSG00000069188. [Q58EX2-1]
GeneIDi54549.
KEGGihsa:54549.
UCSCiuc010dfm.4. human. [Q58EX2-1]

Organism-specific databases

CTDi54549.
GeneCardsiSDK2.
H-InvDBHIX0019364.
HGNCiHGNC:19308. SDK2.
HPAiHPA014725.
MIMi607217. gene.
neXtProtiNX_Q58EX2.
PharmGKBiPA134981456.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJJ. Eukaryota.
ENOG410YMNG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG080083.
InParanoidiQ58EX2.
KOiK16353.
OMAiNRERPQA.
OrthoDBiEOG7MPRCZ.
PhylomeDBiQ58EX2.
TreeFamiTF316846.

Miscellaneous databases

ChiTaRSiSDK2. human.
EvolutionaryTraceiQ58EX2.
GeneWikiiSDK2.
GenomeRNAii54549.
NextBioi57007.
PROiQ58EX2.
SOURCEiSearch...

Gene expression databases

BgeeiQ58EX2.
CleanExiHS_SDK2.
ExpressionAtlasiQ58EX2. baseline and differential.
GenevisibleiQ58EX2. HS.

Family and domain databases

Gene3Di2.60.40.10. 19 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 13 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 13 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 7 hits.
PROSITEiPS50853. FN3. 13 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 324-1921 (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-2172 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 825-2172 (ISOFORM 3).
    Tissue: Eye.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1032-2172 (ISOFORM 4).
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1520-2172 (ISOFORM 1).
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of the first, fourth and eighth FN3 domain of sidekick-2 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 589-687; 885-990 AND 1281-1397.

Entry informationi

Entry nameiSDK2_HUMAN
AccessioniPrimary (citable) accession number: Q58EX2
Secondary accession number(s): A6NMR8
, C9JA57, Q86VY3, Q9NTD2, Q9NVB3, Q9P214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.