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Protein

Elongation factor 1-alpha

Gene

Eef1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factorUniRule annotationImported
Biological processProtein biosynthesis
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alphaUniRule annotation
Gene namesi
Name:Eef1a1Imported
ORF Names:mCG_15232Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096881 Eef1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ58E64
PRIDEiQ58E64

Expressioni

Gene expression databases

BgeeiENSMUSG00000037742
ExpressionAtlasiQ58E64 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ58E64, 1 interactor

Structurei

3D structure databases

SMRiQ58E64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 242Tr-type GInterPro annotationAdd BLAST238

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0052 Eukaryota
COG5256 LUCA
HOVERGENiHBG000179
KOiK03231
OMAiPAKETKM
OrthoDBiEOG091G05LW

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58E64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV
160 170 180 190 200
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN
210 220 230 240 250
MLEPSANMPW FKGWKVTRKD GSASGTTLLE ALDCILPPTR PTDKPLRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS
310 320 330 340 350
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP
360 370 380 390 400
GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA
410 420 430 440 450
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK
460
VTKSAQKAQK AK
Length:462
Mass (Da):50,114
Last modified:May 10, 2005 - v1
Checksum:i71072871DE7405DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092053 mRNA Translation: AAH92053.1
BC092276 mRNA Translation: AAH92276.1
BC095965 mRNA Translation: AAH95965.1
BC108391 mRNA Translation: AAI08392.1
AK135448 mRNA Translation: BAE22537.1
AK137223 mRNA Translation: BAE23278.1
AK150798 mRNA Translation: BAE29861.1
AK151773 mRNA Translation: BAE30679.1
AK152810 mRNA Translation: BAE31515.1
AK153387 mRNA Translation: BAE31951.1
AK153402 mRNA Translation: BAE31962.1
AK162049 mRNA Translation: BAE36697.1
AK162313 mRNA Translation: BAE36848.1
AK162440 mRNA Translation: BAE36918.1
AK163799 mRNA Translation: BAE37497.1
AK164113 mRNA Translation: BAE37633.1
AK164671 mRNA Translation: BAE37870.1
AK165938 mRNA Translation: BAE38472.1
AK166021 mRNA Translation: BAE38526.1
AK166033 mRNA Translation: BAE38534.1
AK166058 mRNA Translation: BAE38549.1
AK166089 mRNA Translation: BAE38564.1
AK166615 mRNA Translation: BAE38895.1
AK166807 mRNA Translation: BAE39035.1
CH466522 Genomic DNA Translation: EDL26400.1
RefSeqiNP_034236.2, NM_010106.2
UniGeneiMm.138471
Mm.335315
Mm.360075
Mm.391071
Mm.485669
Mm.491424

Genome annotation databases

GeneIDi13627
KEGGimmu:13627

Similar proteinsi

Entry informationi

Entry nameiQ58E64_MOUSE
AccessioniPrimary (citable) accession number: Q58E64
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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