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Protein
Submitted name:

Hdac1 protein

Gene

Hdac1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. activating transcription factor binding Source: MGI
  2. chromatin binding Source: MGI
  3. core promoter binding Source: MGI
  4. DNA binding Source: MGI
  5. enzyme binding Source: MGI
  6. histone deacetylase activity Source: MGI
  7. histone deacetylase binding Source: MGI
  8. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  9. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  10. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  11. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  12. protein deacetylase activity Source: MGI
  13. protein N-terminus binding Source: MGI
  14. repressing transcription factor binding Source: MGI
  15. RNA polymerase II repressing transcription factor binding Source: MGI
  16. RNA polymerase II transcription corepressor activity Source: MGI
  17. sequence-specific DNA binding transcription factor activity Source: MGI
  18. transcription corepressor activity Source: MGI
  19. transcription factor binding Source: MGI
  20. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: MGI
  2. endoderm development Source: MGI
  3. hippocampus development Source: MGI
  4. histone deacetylation Source: MGI
  5. histone H3 deacetylation Source: MGI
  6. histone H4 deacetylation Source: MGI
  7. negative regulation by host of viral transcription Source: MGI
  8. negative regulation of androgen receptor signaling pathway Source: MGI
  9. negative regulation of canonical Wnt signaling pathway Source: MGI
  10. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  11. negative regulation of intrinsic apoptotic signaling pathway Source: MGI
  12. negative regulation of transcription, DNA-templated Source: MGI
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. neuron differentiation Source: MGI
  15. positive regulation of cell proliferation Source: MGI
  16. positive regulation of oligodendrocyte differentiation Source: MGI
  17. positive regulation of receptor biosynthetic process Source: MGI
  18. positive regulation of transcription, DNA-templated Source: MGI
  19. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  20. protein deacetylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac1 proteinImported
Gene namesi
Name:Hdac1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108086. Hdac1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromatin Source: MGI
  2. cytosol Source: MGI
  3. heterochromatin Source: MGI
  4. histone deacetylase complex Source: MGI
  5. neuronal cell body Source: MGI
  6. nuclear chromatin Source: MGI
  7. nucleoplasm Source: MGI
  8. nucleus Source: MGI
  9. NuRD complex Source: MGI
  10. protein complex Source: MGI
  11. Sin3 complex Source: MGI
  12. transcriptional repressor complex Source: MGI
  13. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ58E49.
PRIDEiQ58E49.

Expressioni

Gene expression databases

BgeeiQ58E49.
ExpressionAtlasiQ58E49. baseline and differential.
GenevestigatoriQ58E49.

Interactioni

Protein-protein interaction databases

IntActiQ58E49. 1 interaction.
MINTiMINT-8174158.
STRINGi10090.ENSMUSP00000099657.

Structurei

3D structure databases

ProteinModelPortaliQ58E49.
SMRiQ58E49. Positions 8-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOVERGENiHBG057112.
KOiK06067.
OMAiLTQGTKR.
PhylomeDBiQ58E49.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q58E49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK
60 70 80 90 100
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC
110 120 130 140 150
PVFDGLFEFC QLSTGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF
160 170 180 190 200
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK
210 220 230 240 250
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVMSKVME
260 270 280 290 300
MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
310 320 330 340 350
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM
360 370 380 390 400
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED
410 420 430 440 450
PDKRISICSS DKRIACEEEF SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE
460 470 480
KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK LA
Length:482
Mass (Da):55,075
Last modified:May 10, 2005 - v1
Checksum:i7F64D3C17F5E4844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092070 mRNA. Translation: AAH92070.1.
BC108371 mRNA. Translation: AAI08372.1.
RefSeqiNP_032254.1. NM_008228.2.
UniGeneiMm.202504.
Mm.391033.

Genome annotation databases

GeneIDi433759.
KEGGimmu:433759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092070 mRNA. Translation: AAH92070.1.
BC108371 mRNA. Translation: AAI08372.1.
RefSeqiNP_032254.1. NM_008228.2.
UniGeneiMm.202504.
Mm.391033.

3D structure databases

ProteinModelPortaliQ58E49.
SMRiQ58E49. Positions 8-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ58E49. 1 interaction.
MINTiMINT-8174158.
STRINGi10090.ENSMUSP00000099657.

Chemistry

BindingDBiQ58E49.

Proteomic databases

PaxDbiQ58E49.
PRIDEiQ58E49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi433759.
KEGGimmu:433759.

Organism-specific databases

CTDi3065.
MGIiMGI:108086. Hdac1.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOVERGENiHBG057112.
KOiK06067.
OMAiLTQGTKR.
PhylomeDBiQ58E49.

Miscellaneous databases

NextBioi408961.
SOURCEiSearch...

Gene expression databases

BgeeiQ58E49.
ExpressionAtlasiQ58E49. baseline and differential.
GenevestigatoriQ58E49.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: ColonImported and Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ58E49_MOUSE
AccessioniPrimary (citable) accession number: Q58E49
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.