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Q58E49 (Q58E49_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone deacetylase PIRNR PIRNR037913

EC=3.5.1.98 PIRNR PIRNR037913
Gene names
Name:Hdac1 MGI 108086 EMBL AAH92070.1
OrganismMus musculus (Mouse) EMBL AAH92070.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913

Subcellular location

Nucleus By similarity PIRNR PIRNR037913.

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
   Biological processTranscription
Transcription regulation PIRNR PIRNR037913
   Cellular componentNucleus PIRNR PIRNR037913
   Molecular functionChromatin regulator PIRNR PIRNR037913
Hydrolase SAAS SAAS023801 PIRNR PIRNR037913
Gene Ontology (GO)
   Biological_processendoderm development

Inferred from direct assay PubMed 15060137. Source: MGI

hippocampus development

Inferred from genetic interaction PubMed 19380719. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19503085. Source: MGI

negative regulation of intrinsic apoptotic signaling pathway

Inferred from genetic interaction PubMed 21093383. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8917507PubMed 9271381. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 9271381. Source: MGI

neuron differentiation

Inferred from genetic interaction PubMed 19380719. Source: MGI

positive regulation of oligodendrocyte differentiation

Inferred from genetic interaction PubMed 19503085. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentNuRD complex

Inferred from direct assay PubMed 11836251PubMed 22075476. Source: MGI

heterochromatin

Inferred from direct assay PubMed 14519686PubMed 14643676. Source: MGI

histone deacetylase complex

Inferred from physical interaction PubMed 14645126. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 18651664. Source: MGI

nucleus

Inferred from direct assay PubMed 20720167PubMed 21874024. Source: MGI

protein complex

Inferred from direct assay PubMed 19796622. Source: MGI

transcription factor complex

Inferred from physical interaction PubMed 17182846. Source: MGI

transcriptional repressor complex

Inferred from physical interaction PubMed 17182846. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14593184PubMed 15608638. Source: MGI

NAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

RNA polymerase II repressing transcription factor binding

Inferred from physical interaction PubMed 19235719. Source: MGI

chromatin binding

Inferred from direct assay PubMed 16109736PubMed 16678101PubMed 17905753. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 17392792. Source: MGI

transcription corepressor activity

Inferred from direct assay PubMed 15509593PubMed 8917507. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q58E49 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 7F64D3C17F5E4844

FASTA48255,075
        10         20         30         40         50         60 
MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 

        70         80         90        100        110        120 
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 

       130        140        150        160        170        180 
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 

       190        200        210        220        230        240 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 

       250        260        270        280        290        300 
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 

       310        320        330        340        350        360 
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 

       370        380        390        400        410        420 
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF 

       430        440        450        460        470        480 
SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 


LA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH92070.1.
Tissue: Colon EMBL AAH92070.1 and Mammary tumor. C3 EMBL AAI08372.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC092070 mRNA. Translation: AAH92070.1.
BC108371 mRNA. Translation: AAI08372.1.
RefSeqNP_032254.1. NM_008228.2.
UniGeneMm.202504.
Mm.391033.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8174158.
STRING10090.ENSMUSP00000099657.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID433759.
KEGGmmu:433759.

Organism-specific databases

CTD3065.
MGIMGI:108086. Hdac1.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00530000062889.
HOVERGENHBG057112.
InParanoidQ58E49.
KOK06067.
OMALTQGTKR.

Gene expression databases

GenevestigatorQ58E49.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

NextBio408961.
SOURCESearch...

Entry information

Entry nameQ58E49_MOUSE
AccessionPrimary (citable) accession number: Q58E49
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)