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Protein
Submitted name:

Sphingosine kinase 2

Gene

Sphk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingosine kinase 2Imported
Submitted name:
Sphingosine kinase 2, isoform CRA_aImported
Gene namesi
Name:Sphk2Imported
ORF Names:mCG_10315Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1861380. Sphk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000057342.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072615.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 290148DAGKcInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
HOVERGENiHBG054796.
KOiK04718.
OMAiLMCLLRG.
OrthoDBiEOG091G06SM.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58E38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPPLLPVA ASTPILHGEF GSYPANGPRF ALTLTTQALH IQRLRPKPEA
60 70 80 90 100
RPRDGLVSLD EVSGCGTLQS RSPEDTAAYF CIYTYPRGRR GGRRRATRTF
110 120 130 140 150
RADGATTYEE NRAEAQRWAT ALTCLLRGVP LSGDQEITPE LLPRKPRLLI
160 170 180 190 200
LVNPFGGRGL AWQRCMDHVV PMISEAGLSF NLIQTERQNH ARELVQGLSL
210 220 230 240 250
SEWEGIVTVS GDGLLYEVLN GLLDRPDWED AVRMPIGVLP CGSGNALAGA
260 270 280 290 300
VNHHGGFEQV VGVDLLLNCS LLLCRGGSHP LDLLSVTLAS GSRCFSFLSV
310 320 330 340 350
AWGFLSDVDI HSERFRALGS ARFTLGAVLG LASLHTYRGR LSYLPATTEP
360 370 380 390 400
ALPIPGHSLP RAKSELVLAP APAPAATHSP LHRSVSDLPL PLPQPALVSP
410 420 430 440 450
GSPEPLPDLS LNGGGPELTG DWGGAGDAPL SPDPLLPSSP NALKTAQLSP
460 470 480 490 500
IAEGPPEMPA SSGFLPPTHS APEASTWGPV DHLLPPLGSP LPQDWVTIEG
510 520 530 540 550
EFVLMLGILP SHLCADLMAA PHARFDDGVV HLCWVRSGIS RAALLRILLA
560 570 580 590 600
MEHGNHFSLG CPHLGYAAAR AFRLEPLTPR GLLTVDGELV EYGPIQAQVH
610
PGLATLLTGP AGQKPQA
Length:617
Mass (Da):65,618
Last modified:May 10, 2005 - v1
Checksum:i40EE2C2C288BE26A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092084 mRNA. Translation: AAH92084.1.
AK154321 mRNA. Translation: BAE32512.1.
CH466603 Genomic DNA. Translation: EDL22887.1.
CH466603 Genomic DNA. Translation: EDL22888.1.
CH466603 Genomic DNA. Translation: EDL22889.1.
RefSeqiNP_001166032.1. NM_001172561.1.
NP_064395.2. NM_020011.5.
NP_975009.1. NM_203280.3.
XP_006541075.1. XM_006541012.2.
XP_006541076.1. XM_006541013.2.
UniGeneiMm.24222.
Mm.378235.

Genome annotation databases

GeneIDi56632.
KEGGimmu:56632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092084 mRNA. Translation: AAH92084.1.
AK154321 mRNA. Translation: BAE32512.1.
CH466603 Genomic DNA. Translation: EDL22887.1.
CH466603 Genomic DNA. Translation: EDL22888.1.
CH466603 Genomic DNA. Translation: EDL22889.1.
RefSeqiNP_001166032.1. NM_001172561.1.
NP_064395.2. NM_020011.5.
NP_975009.1. NM_203280.3.
XP_006541075.1. XM_006541012.2.
XP_006541076.1. XM_006541013.2.
UniGeneiMm.24222.
Mm.378235.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072615.

Protocols and materials databases

DNASUi56632.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56632.
KEGGimmu:56632.

Organism-specific databases

CTDi56848.
MGIiMGI:1861380. Sphk2.

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
HOVERGENiHBG054796.
KOiK04718.
OMAiLMCLLRG.
OrthoDBiEOG091G06SM.

Miscellaneous databases

ChiTaRSiSphk2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057342.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ58E38_MOUSE
AccessioniPrimary (citable) accession number: Q58E38
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.