UniProtKB - Q58DW0 (RL4_BOVIN)
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Protein
60S ribosomal protein L4
Gene
RPL4
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L4 |
Gene namesi | Name:RPL4 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000129348 | 2 – 422 | 60S ribosomal protein L4Add BLAST | 421 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 14 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 97 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 106 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 259 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 266 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 290 | PhosphoserineBy similarity | 1 | |
Modified residuei | 295 | PhosphoserineBy similarity | 1 | |
Modified residuei | 300 | CitrullineBy similarity | 1 | |
Cross-linki | 327 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 333 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 353 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 361 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 361 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Modified residuei | 362 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Citrullinated by PADI4.By similarity
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q58DW0. |
PeptideAtlasi | Q58DW0. |
PRIDEi | Q58DW0. |
Interactioni
Subunit structurei
Interacts with RBM3. May bind IPO9 with low affinity (By similarity).By similarity
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000006866. |
Structurei
3D structure databases
ProteinModelPortali | Q58DW0. |
SMRi | Q58DW0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 361 – 419 | Lys-richAdd BLAST | 59 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL4 family.Curated
Phylogenomic databases
eggNOGi | KOG1475. Eukaryota. COG0088. LUCA. |
GeneTreei | ENSGT00390000018145. |
HOGENOMi | HOG000107331. |
HOVERGENi | HBG001453. |
InParanoidi | Q58DW0. |
KOi | K02930. |
OMAi | GRGKMRN. |
OrthoDBi | EOG091G0A2I. |
TreeFami | TF300593. |
Family and domain databases
Gene3Di | 3.40.1370.10. 1 hit. |
InterProi | View protein in InterPro IPR025755. Ribos_L4_C_dom. IPR002136. Ribosomal_L4/L1e. IPR013000. Ribosomal_L4/L1e_euk/arc_CS. IPR023574. Ribosomal_L4_dom_sf. |
Pfami | View protein in Pfam PF14374. Ribos_L4_asso_C. 1 hit. PF00573. Ribosomal_L4. 1 hit. |
SUPFAMi | SSF52166. SSF52166. 1 hit. |
PROSITEi | View protein in PROSITE PS00939. RIBOSOMAL_L1E. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q58DW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL
160 170 180 190 200
PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMLNTDLS RILKSPEIQR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKIR
360 370 380 390 400
MDKAAAALEA KSDQKGVQGK KPVVGNKEKK AVGDKKLKKP VVGKKAAGTK
410 420
KPAAEKKPTE KKPTSEEKKA AA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021487 mRNA. Translation: AAX46334.1. BC102521 mRNA. Translation: AAI02522.1. |
RefSeqi | NP_001014894.1. NM_001014894.1. |
UniGenei | Bt.48893. |
Genome annotation databases
Ensembli | ENSBTAT00000006866; ENSBTAP00000006866; ENSBTAG00000005211. |
GeneIDi | 510547. |
KEGGi | bta:510547. |
Similar proteinsi
Entry informationi
Entry namei | RL4_BOVIN | |
Accessioni | Q58DW0Primary (citable) accession number: Q58DW0 Secondary accession number(s): Q3T088 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 28, 2018 | |
This is version 86 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |