RPL4

Functionⁱ

GO - Molecular functionⁱ

RNA binding Source: GO_Central
structural constituent of ribosome Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

cytoplasmic translation Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression. R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane. R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol. R-BTA-72689. Formation of a pool of free 40S subunits. R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Reactomeⁱ

R-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L4
Gene namesⁱ	Name:RPL4
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 10

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosolic large ribosomal subunit Source: GO_Central

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000129348	2 – 422	60S ribosomal protein L4Add BLAST		421

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	14	N6-acetyllysineBy similarity	1
Modified residueⁱ	97	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	106	N6-acetyllysineBy similarity	1
Modified residueⁱ	259	N6-acetyllysineBy similarity	1
Modified residueⁱ	266	PhosphothreonineBy similarity	1
Modified residueⁱ	290	PhosphoserineBy similarity	1
Modified residueⁱ	295	PhosphoserineBy similarity	1
Modified residueⁱ	300	CitrullineBy similarity	1
Modified residueⁱ	333	N6-acetyllysineBy similarity	1
Modified residueⁱ	353	N6-acetyllysineBy similarity	1
Modified residueⁱ	361	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	361	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residueⁱ	362	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Citrullinated by PADI4.By similarity

Keywords - PTMⁱ

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q58DW0.
PeptideAtlas More...PeptideAtlasⁱ	Q58DW0.
PRIDEⁱ	Q58DW0.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000005211.

Bgeeⁱ

ENSBTAG00000005211.

Interactionⁱ

Subunit structureⁱ

Interacts with RBM3. May bind IPO9 with low affinity (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000006866.

STRINGⁱ

9913.ENSBTAP00000006866.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q58DW0.
SMRⁱ	Q58DW0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	361 – 419	Lys-richAdd BLAST		59

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL4 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1475. Eukaryota. COG0088. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018145.
HOGENOMⁱ	HOG000107331.
HOVERGENⁱ	HBG001453.
InParanoidⁱ	Q58DW0.
KEGG Orthology (KO) More...KOⁱ	K02930.
OMAⁱ	GRGKMRN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2I.
TreeFamⁱ	TF300593.

Family and domain databases

Gene3Dⁱ	3.40.1370.10. 1 hit.
InterProⁱ	View protein in InterPro IPR025755. Ribos_L4_C_dom. IPR002136. Ribosomal_L4/L1e. IPR013000. Ribosomal_L4/L1e_euk/arc_CS. IPR023574. Ribosomal_L4_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14374. Ribos_L4_asso_C. 1 hit. PF00573. Ribosomal_L4. 1 hit.
SUPFAMⁱ	SSF52166. SSF52166. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00939. RIBOSOMAL_L1E. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q58DW0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ 
        60         70         80         90        100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR 
       110        120        130        140        150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL 
       160        170        180        190        200
PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR 
       210        220        230        240        250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC 
       260        270        280        290        300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMLNTDLS RILKSPEIQR 
       310        320        330        340        350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKIR 
       360        370        380        390        400
MDKAAAALEA KSDQKGVQGK KPVVGNKEKK AVGDKKLKKP VVGKKAAGTK 
       410        420 
KPAAEKKPTE KKPTSEEKKA AA

Length:422

Mass (Da):47,412

Last modified:January 23, 2007 - v3

Checksum:ⁱADC3F06A6EA3F8E3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT021487 mRNA. Translation: AAX46334.1. BC102521 mRNA. Translation: AAI02522.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001014894.1. NM_001014894.1.
UniGeneⁱ	Bt.48893.

Genome annotation databases

Ensemblⁱ	ENSBTAT00000006866; ENSBTAP00000006866; ENSBTAG00000005211.
GeneIDⁱ	510547.
KEGGⁱ	bta:510547.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT021487 mRNA. Translation: AAX46334.1. BC102521 mRNA. Translation: AAI02522.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001014894.1. NM_001014894.1.
UniGeneⁱ	Bt.48893.

3D structure databases

ProteinModelPortalⁱ	Q58DW0.
SMRⁱ	Q58DW0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000006866.

STRINGⁱ

9913.ENSBTAP00000006866.

Proteomic databases

PaxDbⁱ	Q58DW0.
PeptideAtlas More...PeptideAtlasⁱ	Q58DW0.
PRIDEⁱ	Q58DW0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000006866; ENSBTAP00000006866; ENSBTAG00000005211.
GeneIDⁱ	510547.
KEGGⁱ	bta:510547.

Organism-specific databases

CTDⁱ	6124.

CTDⁱ

6124.

Phylogenomic databases

eggNOGⁱ	KOG1475. Eukaryota. COG0088. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018145.
HOGENOMⁱ	HOG000107331.
HOVERGENⁱ	HBG001453.
InParanoidⁱ	Q58DW0.
KEGG Orthology (KO) More...KOⁱ	K02930.
OMAⁱ	GRGKMRN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2I.
TreeFamⁱ	TF300593.

Enzyme and pathway databases

Reactomeⁱ	R-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression. R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane. R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol. R-BTA-72689. Formation of a pool of free 40S subunits. R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Reactomeⁱ

R-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

Bgeeⁱ	ENSBTAG00000005211.

Bgeeⁱ

ENSBTAG00000005211.

Family and domain databases

Gene3Dⁱ	3.40.1370.10. 1 hit.
InterProⁱ	View protein in InterPro IPR025755. Ribos_L4_C_dom. IPR002136. Ribosomal_L4/L1e. IPR013000. Ribosomal_L4/L1e_euk/arc_CS. IPR023574. Ribosomal_L4_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14374. Ribos_L4_asso_C. 1 hit. PF00573. Ribosomal_L4. 1 hit.
SUPFAMⁱ	SSF52166. SSF52166. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00939. RIBOSOMAL_L1E. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RL4_BOVIN
Accessionⁱ	Q58DW0Primary (citable) accession number: Q58DW0 Secondary accession number(s): Q3T088
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	January 23, 2007
	Last modified:	July 5, 2017
	This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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Supporting data

UniProtKB - Q58DW0 (RL4_BOVIN)

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60S ribosomal protein L4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ