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Q58DV7

- HNMT_BOVIN

UniProt

Q58DV7 - HNMT_BOVIN

Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstratePROSITE-ProRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histamine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.8)
    Short name:
    HMT
    Gene namesi
    Name:HNMT
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Histamine N-methyltransferasePRO_0000084019Add
    BLAST

    Proteomic databases

    PRIDEiQ58DV7.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ58DV7.
    SMRiQ58DV7. Positions 5-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39680.
    GeneTreeiENSGT00390000002862.
    HOGENOMiHOG000231790.
    HOVERGENiHBG051914.
    InParanoidiQ58DV7.
    KOiK00546.
    OMAiMDISDCF.
    OrthoDBiEOG7Z69CQ.
    TreeFamiTF331080.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58DV7-1 [UniParc]FASTAAdd to Basket

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    MASSMRSLFT DHSRYVESFR RFLSNSTEHQ CMQEFMDKKL PGIIARIGDI    50
    KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VHIINEVVEP SAEQITKYKE 100
    LVAKTSNLEN IKFAWHKETS SEYQNRMMEK KELQRWDFIH MIQMLYYVKD 150
    IPATLKFFHS LLATNAKILI IIVSGASSWQ KLWEKYGSRL PRNDLCQYVT 200
    SSDLTQMLDK LGIKYEYYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF 250
    NTTAPPDLKA EIMKDLQKPE FSIKKEGKVL FNNSLSFIVV EA 292
    Length:292
    Mass (Da):33,646
    Last modified:April 26, 2005 - v1
    Checksum:iF86A32390137EECC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021490 mRNA. Translation: AAX46337.1.
    BC114060 mRNA. Translation: AAI14061.1.
    RefSeqiNP_001030511.1. NM_001035434.1.
    UniGeneiBt.65743.

    Genome annotation databases

    EnsembliENSBTAT00000019196; ENSBTAP00000019196; ENSBTAG00000014432.
    GeneIDi613413.
    KEGGibta:613413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021490 mRNA. Translation: AAX46337.1 .
    BC114060 mRNA. Translation: AAI14061.1 .
    RefSeqi NP_001030511.1. NM_001035434.1.
    UniGenei Bt.65743.

    3D structure databases

    ProteinModelPortali Q58DV7.
    SMRi Q58DV7. Positions 5-292.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q58DV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000019196 ; ENSBTAP00000019196 ; ENSBTAG00000014432 .
    GeneIDi 613413.
    KEGGi bta:613413.

    Organism-specific databases

    CTDi 3176.

    Phylogenomic databases

    eggNOGi NOG39680.
    GeneTreei ENSGT00390000002862.
    HOGENOMi HOG000231790.
    HOVERGENi HBG051914.
    InParanoidi Q58DV7.
    KOi K00546.
    OMAi MDISDCF.
    OrthoDBi EOG7Z69CQ.
    TreeFami TF331080.

    Miscellaneous databases

    NextBioi 20898563.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiHNMT_BOVIN
    AccessioniPrimary (citable) accession number: Q58DV7
    Secondary accession number(s): Q29RR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3