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Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstratePROSITE-ProRule annotation1
Binding sitei60S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei89S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei94S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei120S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei142S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei283SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-BTA-70921 Histidine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8By similarity)
Short name:
HMT
Gene namesi
Name:HNMT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:29893 HNMT

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840191 – 292Histamine N-methyltransferaseAdd BLAST292

Proteomic databases

PaxDbiQ58DV7
PRIDEiQ58DV7

Expressioni

Gene expression databases

BgeeiENSBTAG00000014432

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019196

Structurei

3D structure databases

ProteinModelPortaliQ58DV7
SMRiQ58DV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGS0 Eukaryota
ENOG410ZU1D LUCA
GeneTreeiENSGT00390000002862
HOGENOMiHOG000231790
HOVERGENiHBG051914
InParanoidiQ58DV7
KOiK00546
OMAiMDISDCF
OrthoDBiEOG091G0DY6
TreeFamiTF331080

Family and domain databases

InterProiView protein in InterPro
IPR016673 HHMT-like
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF016616 HHMT, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51597 SAM_HNMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q58DV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSMRSLFT DHSRYVESFR RFLSNSTEHQ CMQEFMDKKL PGIIARIGDI
60 70 80 90 100
KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VHIINEVVEP SAEQITKYKE
110 120 130 140 150
LVAKTSNLEN IKFAWHKETS SEYQNRMMEK KELQRWDFIH MIQMLYYVKD
160 170 180 190 200
IPATLKFFHS LLATNAKILI IIVSGASSWQ KLWEKYGSRL PRNDLCQYVT
210 220 230 240 250
SSDLTQMLDK LGIKYEYYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF
260 270 280 290
NTTAPPDLKA EIMKDLQKPE FSIKKEGKVL FNNSLSFIVV EA
Length:292
Mass (Da):33,646
Last modified:April 26, 2005 - v1
Checksum:iF86A32390137EECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021490 mRNA Translation: AAX46337.1
BC114060 mRNA Translation: AAI14061.1
RefSeqiNP_001030511.1, NM_001035434.1
XP_010800392.1, XM_010802090.2
UniGeneiBt.65743

Genome annotation databases

EnsembliENSBTAT00000019196; ENSBTAP00000019196; ENSBTAG00000014432
GeneIDi613413
KEGGibta:613413

Similar proteinsi

Entry informationi

Entry nameiHNMT_BOVIN
AccessioniPrimary (citable) accession number: Q58DV7
Secondary accession number(s): Q29RR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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