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Q58DV7 (HNMT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine N-methyltransferase

Short name=HMT
EC=2.1.1.8
Gene names
Name:HNMT
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Histamine N-methyltransferase
PRO_0000084019

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58DV7 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: F86A32390137EECC

FASTA29233,646
        10         20         30         40         50         60 
MASSMRSLFT DHSRYVESFR RFLSNSTEHQ CMQEFMDKKL PGIIARIGDI KSEIKILSIG 

        70         80         90        100        110        120 
GGAGEIDLQI LSKVQAQYPG VHIINEVVEP SAEQITKYKE LVAKTSNLEN IKFAWHKETS 

       130        140        150        160        170        180 
SEYQNRMMEK KELQRWDFIH MIQMLYYVKD IPATLKFFHS LLATNAKILI IIVSGASSWQ 

       190        200        210        220        230        240 
KLWEKYGSRL PRNDLCQYVT SSDLTQMLDK LGIKYEYYDL LSTMDISDCF IDGNENGDLL 

       250        260        270        280        290 
WDFLTETCNF NTTAPPDLKA EIMKDLQKPE FSIKKEGKVL FNNSLSFIVV EA 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT021490 mRNA. Translation: AAX46337.1.
BC114060 mRNA. Translation: AAI14061.1.
RefSeqNP_001030511.1. NM_001035434.1.
UniGeneBt.65743.

3D structure databases

ProteinModelPortalQ58DV7.
SMRQ58DV7. Positions 5-292.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ58DV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000019196; ENSBTAP00000019196; ENSBTAG00000014432.
GeneID613413.
KEGGbta:613413.

Organism-specific databases

CTD3176.

Phylogenomic databases

eggNOGNOG39680.
GeneTreeENSGT00390000002862.
HOGENOMHOG000231790.
HOVERGENHBG051914.
InParanoidQ58DV7.
KOK00546.
OMAMDISDCF.
OrthoDBEOG7Z69CQ.
TreeFamTF331080.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFPIRSF016616. HHMT. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20898563.

Entry information

Entry nameHNMT_BOVIN
AccessionPrimary (citable) accession number: Q58DV7
Secondary accession number(s): Q29RR4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families