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Q58DV7

- HNMT_BOVIN

UniProt

Q58DV7 - HNMT_BOVIN

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Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:HNMT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Histamine N-methyltransferasePRO_0000084019Add
BLAST

Proteomic databases

PRIDEiQ58DV7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ58DV7.
SMRiQ58DV7. Positions 5-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39680.
GeneTreeiENSGT00390000002862.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ58DV7.
KOiK00546.
OMAiMDISDCF.
OrthoDBiEOG7Z69CQ.
TreeFamiTF331080.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58DV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSMRSLFT DHSRYVESFR RFLSNSTEHQ CMQEFMDKKL PGIIARIGDI
60 70 80 90 100
KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VHIINEVVEP SAEQITKYKE
110 120 130 140 150
LVAKTSNLEN IKFAWHKETS SEYQNRMMEK KELQRWDFIH MIQMLYYVKD
160 170 180 190 200
IPATLKFFHS LLATNAKILI IIVSGASSWQ KLWEKYGSRL PRNDLCQYVT
210 220 230 240 250
SSDLTQMLDK LGIKYEYYDL LSTMDISDCF IDGNENGDLL WDFLTETCNF
260 270 280 290
NTTAPPDLKA EIMKDLQKPE FSIKKEGKVL FNNSLSFIVV EA
Length:292
Mass (Da):33,646
Last modified:April 26, 2005 - v1
Checksum:iF86A32390137EECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021490 mRNA. Translation: AAX46337.1.
BC114060 mRNA. Translation: AAI14061.1.
RefSeqiNP_001030511.1. NM_001035434.1.
UniGeneiBt.65743.

Genome annotation databases

EnsembliENSBTAT00000019196; ENSBTAP00000019196; ENSBTAG00000014432.
GeneIDi613413.
KEGGibta:613413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021490 mRNA. Translation: AAX46337.1 .
BC114060 mRNA. Translation: AAI14061.1 .
RefSeqi NP_001030511.1. NM_001035434.1.
UniGenei Bt.65743.

3D structure databases

ProteinModelPortali Q58DV7.
SMRi Q58DV7. Positions 5-292.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q58DV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000019196 ; ENSBTAP00000019196 ; ENSBTAG00000014432 .
GeneIDi 613413.
KEGGi bta:613413.

Organism-specific databases

CTDi 3176.

Phylogenomic databases

eggNOGi NOG39680.
GeneTreei ENSGT00390000002862.
HOGENOMi HOG000231790.
HOVERGENi HBG051914.
InParanoidi Q58DV7.
KOi K00546.
OMAi MDISDCF.
OrthoDBi EOG7Z69CQ.
TreeFami TF331080.

Miscellaneous databases

NextBioi 20898563.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiHNMT_BOVIN
AccessioniPrimary (citable) accession number: Q58DV7
Secondary accession number(s): Q29RR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3