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Protein

Protein pelota homolog

Gene

PELO

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).By similarityCurated

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pelota homolog (EC:3.1.-.-)
Gene namesi
Name:PELO
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328341 – 385Protein pelota homologAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei374PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ58DV0
PRIDEiQ58DV0

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004233

Structurei

3D structure databases

ProteinModelPortaliQ58DV0
SMRiQ58DV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2869 Eukaryota
COG1537 LUCA
HOVERGENiHBG053560
InParanoidiQ58DV0
KOiK06965
OMAiDNLFRCQ
TreeFamiTF105733

Family and domain databases

Gene3Di2.30.30.870, 1 hit
3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR038069 Pelota/DOM34_N
IPR004405 Transl-rel_pelota
PANTHERiPTHR10853 PTHR10853, 1 hit
PfamiView protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit
SMARTiView protein in SMART
SM01194 eRF1_1, 1 hit
SUPFAMiSSF159065 SSF159065, 1 hit
SSF55315 SSF55315, 1 hit
TIGRFAMsiTIGR00111 pelota, 1 hit

Sequencei

Sequence statusi: Complete.

Q58DV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVRKDIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH
110 120 130 140 150
TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHIC
160 170 180 190 200
LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHIHFD
210 220 230 240 250
VVKCVLVASP GFVREQFCDY MFQQAVKTDN KVLLENRSKF LQVHASSGHK
260 270 280 290 300
YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
310 320 330 340 350
KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH
360 370 380
VSGEQLSQLT GIAAILRFPV PELSDQENDS SSEED
Length:385
Mass (Da):43,421
Last modified:November 28, 2006 - v2
Checksum:iE4F3B8C96A27626E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192A → G in ABF57323 (PubMed:16305752).Curated1
Sequence conflicti378N → D in ABF57323 (PubMed:16305752).Curated1
Sequence conflicti385D → DE in AAX46344 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021497 mRNA Translation: AAX46344.1
BT025367 mRNA Translation: ABF57323.1
RefSeqiNP_001029738.1, NM_001034566.1
UniGeneiBt.76149

Genome annotation databases

GeneIDi528728
KEGGibta:528728

Similar proteinsi

Entry informationi

Entry nameiPELO_BOVIN
AccessioniPrimary (citable) accession number: Q58DV0
Secondary accession number(s): Q1JPI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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