Reviewed, UniProtKB/Swiss-Prot Q58DT4 (P5CR1_BOVIN)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 1, mitochondrial
      Short name=P5C reductase 1
      Short name=P5CR 1
    EC=1.5.1.2

Gene names

Name:

PYCR1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Mitochondrion
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 320	319	Pyrroline-5-carboxylate reductase 1, mitochondrial		PRO_0000270817
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58DT4-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 0265F89F283CA765	FASTA	320	33,454
	10 20 30 40 50 60 MSVGFIGAGQ LAFALAKGFT AAGVVAAHKI MASSPDMDLA TVSALRKMGV NLTHHNKETV 70 80 90 100 110 120 QHSDVLFLAV KPHIIPFILD EIAANIEARH IVVSCAAGVT ISSIEKKLTA FQPAPKVIRC 130 140 150 160 170 180 MTNTPVVVRE GATVYATGTH AQVEDGRLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY 190 200 210 220 230 240 AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPGQLKDN VCSPGGATIH 250 260 270 280 290 300 ALHVLESGGF RSLLIKAVEA SCTRTRELQS MADQEKVSPA AIKKTILDKV KLDSPPGTSL 310 320 APSGHSKLLP RSMAPAGKQD

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT021513 mRNA. Translation: AAX46360.1. BC123510 mRNA. Translation: AAI23511.1.
IPI	IPI00694230.
RefSeq	NP_001014957.1.
UniGene	Bt.12489
3D structure databases
SMR	Q58DT4. Positions 1-275.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000000042. Bos taurus. [Contig view]
GeneID	539606.
KEGG	bta:539606.
Phylogenomic databases
HOVERGEN	Q58DT4.
OMA	Q58DT4. APSGHSK.
Enzyme and pathway databases
BRENDA	1.5.1.2. 251.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR1_BOVIN

Accession

Primary (citable) accession number: Q58DT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	April 26, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)