Q58DT3 (ZDHC4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable palmitoyltransferase ZDHHC4
EC=2.3.1.-

Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name=DHHC-4

Gene names

Name:

ZDHHC4

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Probable palmitoyltransferase ZDHHC4		PRO_0000212864
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Zinc finger	149 – 199	51	DHHC-type
Sites
	Active site	179	1	S-palmitoyl cysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58DT3 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 6FF48DFEAE05A22F	FASTA	343	39,710
	10 20 30 40 50 60 MDFLVLFLLY LALVLLGFVM ICIGSKTHYL QGLISRGAQV FSYIIPECLQ RAMLSVLHYL 70 80 90 100 110 120 FHTRNYTFVV LHLILQGMVY TEYTWEIFGL CQQLEFSLYY LFLPYLLLIV NLLFFTLSCV 130 140 150 160 170 180 TNPGTITKAN ELLFLQVYEF DGVMFPKNVR CPTCDLRKPA RSKHCSVCNR CVHRFDHHCV 190 200 210 220 230 240 WVNNCIGAWN TRYFLSYLFT LTASAATMAV VSTVFLVRLV VMSDVYLQTY VDDLGHLQVV 250 260 270 280 290 300 DTVFLVQYLF LTFPRIVFLV GFVVVLSFLL GGYLCFCLYL AATNQTTNEW YKGDRAWCQH 310 320 330 340 CPHVARPPAA EPQAYRNIHS HGLWSNLREI FLPATACYER KEK

References

[1]

"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT021514 mRNA. Translation: AAX46361.1.
IPI	IPI00695708.
RefSeq	NP_001030369.1. NM_001035292.1.
UniGene	Bt.4145.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	514338.
KEGG	bta:514338.
Organism-specific databases
CTD	55146.
Phylogenomic databases
HOVERGEN	HBG054775.
Family and domain databases
InterPro	IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20871283.

Entry information

Entry name

ZDHC4_BOVIN

Accession

Primary (citable) accession number: Q58DT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program