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Protein

Probable palmitoyltransferase ZDHHC4

Gene

ZDHHC4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Gene namesi
Name:ZDHHC4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128641 – 343Probable palmitoyltransferase ZDHHC4Add BLAST343

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ58DT3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012560.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
HOVERGENiHBG054775.
InParanoidiQ58DT3.
KOiK20003.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58DT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLLY LALVLLGFVM ICIGSKTHYL QGLISRGAQV FSYIIPECLQ
60 70 80 90 100
RAMLSVLHYL FHTRNYTFVV LHLILQGMVY TEYTWEIFGL CQQLEFSLYY
110 120 130 140 150
LFLPYLLLIV NLLFFTLSCV TNPGTITKAN ELLFLQVYEF DGVMFPKNVR
160 170 180 190 200
CPTCDLRKPA RSKHCSVCNR CVHRFDHHCV WVNNCIGAWN TRYFLSYLFT
210 220 230 240 250
LTASAATMAV VSTVFLVRLV VMSDVYLQTY VDDLGHLQVV DTVFLVQYLF
260 270 280 290 300
LTFPRIVFLV GFVVVLSFLL GGYLCFCLYL AATNQTTNEW YKGDRAWCQH
310 320 330 340
CPHVARPPAA EPQAYRNIHS HGLWSNLREI FLPATACYER KEK
Length:343
Mass (Da):39,710
Last modified:April 26, 2005 - v1
Checksum:i6FF48DFEAE05A22F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021514 mRNA. Translation: AAX46361.1.
RefSeqiNP_001030369.1. NM_001035292.1.
UniGeneiBt.4145.

Genome annotation databases

GeneIDi514338.
KEGGibta:514338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021514 mRNA. Translation: AAX46361.1.
RefSeqiNP_001030369.1. NM_001035292.1.
UniGeneiBt.4145.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012560.

Proteomic databases

PaxDbiQ58DT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514338.
KEGGibta:514338.

Organism-specific databases

CTDi55146.

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
HOVERGENiHBG054775.
InParanoidiQ58DT3.
KOiK20003.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC4_BOVIN
AccessioniPrimary (citable) accession number: Q58DT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 26, 2005
Last modified: February 15, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.