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Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters.By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Calcium 1; catalyticBy similarity
Metal bindingi54 – 541Calcium 2By similarity
Active sitei114 – 1141Proton acceptorBy similarity
Metal bindingi116 – 1161Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi167 – 1671Calcium 1; catalyticBy similarity
Metal bindingi168 – 1681Calcium 2By similarity
Metal bindingi223 – 2231Calcium 1; catalyticBy similarity
Metal bindingi268 – 2681Calcium 1; catalyticBy similarity
Metal bindingi269 – 2691Calcium 1; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:PON2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Serum paraoxonase/arylesterase 2PRO_0000223285Add
BLAST
Signal peptidei1 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 352By similarity
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ58DS7.
PRIDEiQ58DS7.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011009.

Structurei

3D structure databases

ProteinModelPortaliQ58DS7.
SMRiQ58DS7. Positions 23-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ58DS7.
KOiK01045.
OMAiKHLPNCV.
OrthoDBiEOG7GN2N3.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequencei

Sequence statusi: Complete.

Q58DS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLLALSLL GIALALLGER LLALRNRLKA SREVESVDLP NCHLIKGIEA
60 70 80 90 100
GAEDIDILPN GLAFFSVGLK CPGLHSFAPD KPGGILMMDL NEENPRALEL
110 120 130 140 150
RVSRGFNLAS FNPHGISTFI DSDDTVYLFV VNHPEFKNTV EIFKFEEEEN
160 170 180 190 200
SLLHLKTIKH ELLPSVNDII AVGPEHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WTNVVYYSPN EVKVVAEGFD SANGINISPD KKYIYVADIL AHEIHVLEKH
260 270 280 290 300
PNMNLTQLKV LKLDTLVDNL SIDPSSGDVL VGCHPNGQKL FVYDPKNPPS
310 320 330 340 350
SEVLRIQNIL SEKPTVTTVY ANNGSVLQGS SVASVYDKKL LIGTLYHRAL

YCEL
Length:354
Mass (Da):39,421
Last modified:April 26, 2005 - v1
Checksum:iBB49FA5EC3170239
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321K → R in ABU82767 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF522785 mRNA. Translation: ABU82767.1.
BT021520 mRNA. Translation: AAX46367.1.
BC118371 mRNA. Translation: AAI18372.1.
RefSeqiNP_001013606.1. NM_001013588.1.
UniGeneiBt.23599.

Genome annotation databases

EnsembliENSBTAT00000011009; ENSBTAP00000011009; ENSBTAG00000008361.
GeneIDi281417.
KEGGibta:281417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF522785 mRNA. Translation: ABU82767.1.
BT021520 mRNA. Translation: AAX46367.1.
BC118371 mRNA. Translation: AAI18372.1.
RefSeqiNP_001013606.1. NM_001013588.1.
UniGeneiBt.23599.

3D structure databases

ProteinModelPortaliQ58DS7.
SMRiQ58DS7. Positions 23-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011009.

Proteomic databases

PaxDbiQ58DS7.
PRIDEiQ58DS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011009; ENSBTAP00000011009; ENSBTAG00000008361.
GeneIDi281417.
KEGGibta:281417.

Organism-specific databases

CTDi5445.

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ58DS7.
KOiK01045.
OMAiKHLPNCV.
OrthoDBiEOG7GN2N3.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pon2 gene clone, expression in tissues, bioinformatics and polymorphism analysis of cattle."
    Ji A., Xu S., Gao X., Zhou Z., Huai Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Charolais X Fuzhou.
    Tissue: Sperm.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiPON2_BOVIN
AccessioniPrimary (citable) accession number: Q58DS7
Secondary accession number(s): B2BIS6, Q148F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.