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Protein

Epithelial membrane protein 3

Gene

EMP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Gene namesi
Name:EMP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:28483 EMP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444141 – 163Epithelial membrane protein 3Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ58DR6

Expressioni

Gene expression databases

BgeeiENSBTAG00000018013

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40 Eukaryota
ENOG4111MF9 LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiQ58DR6
OMAiSDLWYNC
OrthoDBiEOG091G0RF4
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003934 EMP_3
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF8 PTHR10671:SF8, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01456 EPMEMPROT3
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58DR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNSDNK
60 70 80 90 100
TWACSNVSEN GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GFCQLCTSVA VFTGALIYAI HAEEILADRP SGGSFGYCFA LAWVAFPLAL
160
ASGIIYIHLR KRE
Length:163
Mass (Da):18,300
Last modified:April 26, 2005 - v1
Checksum:i6E180D986AFB2F5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021531 mRNA Translation: AAX46378.1
BC126787 mRNA Translation: AAI26788.1
RefSeqiNP_001019733.1, NM_001024562.1
XP_015313659.1, XM_015458173.1
UniGeneiBt.48521

Genome annotation databases

EnsembliENSBTAT00000023976; ENSBTAP00000023976; ENSBTAG00000018013
GeneIDi535273
KEGGibta:535273

Entry informationi

Entry nameiEMP3_BOVIN
AccessioniPrimary (citable) accession number: Q58DR6
Secondary accession number(s): A0JNM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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