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Protein

Epithelial membrane protein 3

Gene

EMP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Gene namesi
Name:EMP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Epithelial membrane protein 3PRO_0000244414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ58DR6.
PRIDEiQ58DR6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023976.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ58DR6.
OMAiSDLWYNC.
OrthoDBiEOG7FBRKJ.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58DR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNSDNK
60 70 80 90 100
TWACSNVSEN GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GFCQLCTSVA VFTGALIYAI HAEEILADRP SGGSFGYCFA LAWVAFPLAL
160
ASGIIYIHLR KRE
Length:163
Mass (Da):18,300
Last modified:April 26, 2005 - v1
Checksum:i6E180D986AFB2F5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021531 mRNA. Translation: AAX46378.1.
BC126787 mRNA. Translation: AAI26788.1.
RefSeqiNP_001019733.1. NM_001024562.1.
XP_015313659.1. XM_015458173.1.
UniGeneiBt.48521.

Genome annotation databases

EnsembliENSBTAT00000023976; ENSBTAP00000023976; ENSBTAG00000018013.
GeneIDi535273.
KEGGibta:535273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021531 mRNA. Translation: AAX46378.1.
BC126787 mRNA. Translation: AAI26788.1.
RefSeqiNP_001019733.1. NM_001024562.1.
XP_015313659.1. XM_015458173.1.
UniGeneiBt.48521.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023976.

Proteomic databases

PaxDbiQ58DR6.
PRIDEiQ58DR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023976; ENSBTAP00000023976; ENSBTAG00000018013.
GeneIDi535273.
KEGGibta:535273.

Organism-specific databases

CTDi2014.

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ58DR6.
OMAiSDLWYNC.
OrthoDBiEOG7FBRKJ.
TreeFamiTF330414.

Miscellaneous databases

NextBioi20876680.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.

Entry informationi

Entry nameiEMP3_BOVIN
AccessioniPrimary (citable) accession number: Q58DR6
Secondary accession number(s): A0JNM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.