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Protein

60S ribosomal protein L6

Gene

RPL6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Gene namesi
Name:RPL6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 28728660S ribosomal protein L6PRO_0000171007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei238 – 2381N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ58DQ3.
PeptideAtlasiQ58DQ3.
PRIDEiQ58DQ3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000031723.

Interactioni

Subunit structurei

May bind IPO9 with low affinity.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042411.

Structurei

3D structure databases

ProteinModelPortaliQ58DQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiQ58DQ3.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
TreeFamiTF300115.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKAEKPD TKEKKPEAKK ADAGKKAKKV EKVKKVKKGK PHCSRNPVLV
60 70 80 90 100
RGIGRYSRSA MYSRKALYKR KYSAAKSKVE KKKKVRVLAT VTKPVGGDKN
110 120 130 140 150
GGTRVVKLRK MPRYYPTEDV PRKLLSHGKK PFSKHVRKLR ASITPGTILI
160 170 180 190 200
ILTGRHRGKR VVFLKQLGSG LLLVTGPLSL NRVPLRRTHQ KFVIATSTKI
210 220 230 240 250
DISGVKIPEH LTDTYFKKKK LRKPRHQEGE IFDTEREKYE ITEQRKVDQK
260 270 280
AVDSQILRRI KAVPQLQGYL RSVFALTNGI YPHKVVF
Length:287
Mass (Da):32,690
Last modified:January 23, 2007 - v3
Checksum:iD3546817AB51C143
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021543 mRNA. Translation: AAX46390.1.
BT021544 mRNA. Translation: AAX46391.1.
AY911360 mRNA. Translation: AAW82124.1.
BC133430 mRNA. Translation: AAI33431.1.
RefSeqiNP_001026926.1. NM_001031756.2.
XP_005217842.1. XM_005217785.2.
XP_005217843.1. XM_005217786.2.
UniGeneiBt.62205.

Genome annotation databases

EnsembliENSBTAT00000033359; ENSBTAP00000042411; ENSBTAG00000031723.
GeneIDi511051.
KEGGibta:511051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021543 mRNA. Translation: AAX46390.1.
BT021544 mRNA. Translation: AAX46391.1.
AY911360 mRNA. Translation: AAW82124.1.
BC133430 mRNA. Translation: AAI33431.1.
RefSeqiNP_001026926.1. NM_001031756.2.
XP_005217842.1. XM_005217785.2.
XP_005217843.1. XM_005217786.2.
UniGeneiBt.62205.

3D structure databases

ProteinModelPortaliQ58DQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042411.

Proteomic databases

PaxDbiQ58DQ3.
PeptideAtlasiQ58DQ3.
PRIDEiQ58DQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033359; ENSBTAP00000042411; ENSBTAG00000031723.
GeneIDi511051.
KEGGibta:511051.

Organism-specific databases

CTDi6128.

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiQ58DQ3.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
TreeFamiTF300115.

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

BgeeiENSBTAG00000031723.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL6_BOVIN
AccessioniPrimary (citable) accession number: Q58DQ3
Secondary accession number(s): A3KMZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.