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Protein

Acyl-CoA synthetase family member 3, mitochondrial

Gene

ACSF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei457 – 4571ATPBy similarity
Binding sitei471 – 4711ATPBy similarity
Binding sitei563 – 5631ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi203 – 2119ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase family member 3, mitochondrial (EC:6.2.1.-)
Gene namesi
Name:ACSF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8989MitochondrionSequence analysisAdd
BLAST
Chaini90 – 586497Acyl-CoA synthetase family member 3, mitochondrialPRO_0000315799Add
BLAST

Proteomic databases

PaxDbiQ58DN7.
PRIDEiQ58DN7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021234.

Structurei

3D structure databases

ProteinModelPortaliQ58DN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1176. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229983.
HOVERGENiHBG100430.
InParanoidiQ58DN7.
KOiK18660.
OMAiVGFPLPT.
OrthoDBiEOG7W9RVK.
TreeFamiTF312995.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPYVGMAL RRLAWAVASC RLAPWTRGAS GPLHSAPAAR SDCSAPVFIR
60 70 80 90 100
APAFGDRLAL IDQHGRHTYK DLYLRSLRLS REICQLRACA DGDLREERVS
110 120 130 140 150
LLCSNDVSFV VAQWAAWMSG GVAVPLYRKH PRAQLEYFIQ DSRSSVVLAG
160 170 180 190 200
PEHVELLSPV AQKLGVPLLP LPPTVYHGVA EDPEEGLVLE RNWRDRGAMI
210 220 230 240 250
IYTSGTTGRP KGVLSTHDNI RAVVTGLVHK WAWTKDDVIL HVLPLHHVHG
260 270 280 290 300
VVNKLLCPLW VGATCVMLPE FSAQLVWEKF LSSEAPQINV FMAVPTIYSK
310 320 330 340 350
LMDYYDKHFT QPHVQDFVRA VCEEKIRLMV SGSAALPLPV LEKWKGITGH
360 370 380 390 400
TLLERYGMTE IGMALSNPLT AARLPGSVGT PLPGVEVRIV SENPQKDSSP
410 420 430 440 450
YLIHAEGSEE NTKVTPGFEE KEGELLVRGP SVFREYWDKP EETKAAFTSD
460 470 480 490 500
GWFKTGDTVV FKDGCYWIRG RTSVDIIKSG GYKVSALEVE RLLLAHPSIT
510 520 530 540 550
DVAVIGVPDM TWGQRVTAVV TLQEGHSLSH RELKEWARGV LAPYAVPSEL
560 570 580
LLVEEIPRNQ MGKVNKRDLV RQLYPHEKGA PEAGSQ
Length:586
Mass (Da):64,990
Last modified:April 26, 2005 - v1
Checksum:i5D45A8D1D4C07992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021560 mRNA. Translation: AAX46407.1.
BC102586 mRNA. Translation: AAI02587.1.
RefSeqiNP_001030240.1. NM_001035068.2.
XP_005218566.1. XM_005218509.3.
UniGeneiBt.49591.

Genome annotation databases

EnsembliENSBTAT00000021234; ENSBTAP00000021234; ENSBTAG00000015968.
GeneIDi509209.
KEGGibta:509209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021560 mRNA. Translation: AAX46407.1.
BC102586 mRNA. Translation: AAI02587.1.
RefSeqiNP_001030240.1. NM_001035068.2.
XP_005218566.1. XM_005218509.3.
UniGeneiBt.49591.

3D structure databases

ProteinModelPortaliQ58DN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021234.

Proteomic databases

PaxDbiQ58DN7.
PRIDEiQ58DN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021234; ENSBTAP00000021234; ENSBTAG00000015968.
GeneIDi509209.
KEGGibta:509209.

Organism-specific databases

CTDi197322.

Phylogenomic databases

eggNOGiKOG1176. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229983.
HOVERGENiHBG100430.
InParanoidiQ58DN7.
KOiK18660.
OMAiVGFPLPT.
OrthoDBiEOG7W9RVK.
TreeFamiTF312995.

Enzyme and pathway databases

ReactomeiR-BTA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

NextBioi20868871.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiACSF3_BOVIN
AccessioniPrimary (citable) accession number: Q58DN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: April 13, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.