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Protein

Protein phosphatase methylesterase 1

Gene

PPME1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).By similarity

Catalytic activityi

[Phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei156By similarity1
Active sitei181By similarity1
Active sitei349By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-BTA-69273 Cyclin A/B1/B2 associated events during G2/M transition

Protein family/group databases

ESTHERibovin-ppme1 PPase_methylesterase_euk

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase methylesterase 1 (EC:3.1.1.89)
Short name:
PME-1
Gene namesi
Name:PPME1
Synonyms:PME1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:33218 PPME1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903891 – 380Protein phosphatase methylesterase 1Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei16Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei16Omega-N-methylarginine; alternateBy similarity1
Modified residuei42PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ58DN4
PRIDEiQ58DN4

Expressioni

Gene expression databases

BgeeiENSBTAG00000027612

Interactioni

Subunit structurei

Binds PPP2CA and PPP2CB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000039548

Structurei

3D structure databases

ProteinModelPortaliQ58DN4
SMRiQ58DN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 263Poly-Glu8

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2564 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000004396
HOGENOMiHOG000212435
HOVERGENiHBG053622
InParanoidiQ58DN4
KOiK13617
OMAiRIQCRIV
OrthoDBiEOG091G0D0P
TreeFamiTF314697

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
IPR016812 PPase_methylesterase_euk
PANTHERiPTHR14189 PTHR14189, 1 hit
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
PIRSFiPIRSF022950 PPase_methylesterase_euk, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q58DN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF
60 70 80 90 100
ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII
110 120 130 140 150
SRVQCRIVAL DLRGHGETKV RNSEDLSAET MAKDVGNVVE AMYGDLPPPI
160 170 180 190 200
MLIGHSMGGA IAVHTASSNL VPSLLGLCMI DVVEGTAMDA LNSMQNFLRG
210 220 230 240 250
RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG ITSPEGSKSI
260 270 280 290 300
VEGIIEEEEE DEEGSESVNK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG
310 320 330 340 350
WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA
360 370 380
VHEDAPDKVA EAVATFLIRH RFAEPIGGFQ
Length:380
Mass (Da):41,710
Last modified:January 23, 2007 - v3
Checksum:i61C90BD4625B47A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021563 mRNA Translation: AAX46410.1
BC110227 mRNA Translation: AAI10228.1
RefSeqiNP_001069524.1, NM_001076056.2
UniGeneiBt.51583

Genome annotation databases

EnsembliENSBTAT00000039760; ENSBTAP00000039548; ENSBTAG00000027612
GeneIDi535390
KEGGibta:535390

Similar proteinsi

Entry informationi

Entry nameiPPME1_BOVIN
AccessioniPrimary (citable) accession number: Q58DN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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