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Protein

Breast cancer anti-estrogen resistance protein 3

Gene

BCAR3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an adapter protein and couple activated growth factor receptors to signaling molecules that regulate src kinase activity and promote cell migration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3
Gene namesi
Name:BCAR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002302832 – 826Breast cancer anti-estrogen resistance protein 3Add BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei335N6-methyllysineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ58DL5.
PRIDEiQ58DL5.

Interactioni

Subunit structurei

Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055991.

Structurei

3D structure databases

ProteinModelPortaliQ58DL5.
SMRiQ58DL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 253SH2PROSITE-ProRule annotationAdd BLAST100
Domaini549 – 819Ras-GEFPROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi480 – 483Poly-Asp4

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IFQG. Eukaryota.
ENOG410XTJR. LUCA.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiQ58DL5.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR028849. BCAR3.
IPR023578. Ras_GEF_dom_sf.
IPR001895. RASGEF_cat_dom.
IPR036964. RASGEF_cat_dom_sf.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
PANTHERiPTHR14247:SF10. PTHR14247:SF10. 1 hit.
PfamiView protein in Pfam
PF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
SMARTiView protein in SMART
SM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLVERRAD AYQDVSIHGT
60 70 80 90 100
LPRKKKGPPP IRSCDNFSHV GTLPHSRSPR HHSPLIQDVI QEQPLQDWKG
110 120 130 140 150
EAFTFRDQHL LDPTLEYVKF SKERHVMDRT PERLKKELEE ELLLSSEDLR
160 170 180 190 200
SHAWYHGRIP RQVSENLMQR DGDFLVRDSL SSPGDFVLTC QWKNLPQHFK
210 220 230 240 250
IRRTVVRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP ISQQSGAIIF
260 270 280 290 300
QPVNRTVPLR CLEERYGASS PDRAHEGSLT EGRPDAAKRL SLTVGGTQAR
310 320 330 340 350
EQGLPRGNLL RNKEKSGSQP ACLDHMQDRR ALSLKAHQSE SYLPIGGKLT
360 370 380 390 400
PQSPSVGTSP CPNSPVFRTG SEPTLSPAVV RRVSSDARPG EALRGSDSQL
410 420 430 440 450
CPKPPPKPCK APLLKAPPSP SIWLNSEANY CELNPALAAS YDGASRLPFC
460 470 480 490 500
AQDSYVELLT AKQNGGLGTR NSDTSYLILD DDDRTRPWKP PPAPGDTVGE
510 520 530 540 550
DQDTFVMPLL ETTSSFKPND FESKLLPPEN KPLETSMLKR AKELFTNSDP
560 570 580 590 600
KVIAQHLLSV DCKVARILEV SEEMRKNMGV NSGLELITLP YGHQLRLDII
610 620 630 640 650
ERHNTMAIGI AVDILGCTGS LEDRAATLNK IIQVAVELKD SMGDLYSFSA
660 670 680 690 700
IMKALEMPQI TRLEKTWTAL RHQYTQTAIL YEKQLKPFSK VLHEGRESTC
710 720 730 740 750
VPPNNVSVPL LMPLVTLMER EAVTFEGTDM WEKNDESCEI MLNHLATARL
760 770 780 790 800
MAEAADSYRM NAERILAGFQ PDEEMSEVFK TEFQMRLLWG SKGAQVNQTE
810 820
RYEKFNQILT ALSRKLEPPP VKQMEF
Length:826
Mass (Da):92,765
Last modified:April 4, 2006 - v2
Checksum:i9E5EF3BFF75E9EB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110L → I in AAX46429 (PubMed:16305752).Curated1
Sequence conflicti764R → K in AAI05367 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021582 mRNA. Translation: AAX46429.1.
BC105366 mRNA. Translation: AAI05367.1.
RefSeqiNP_001019654.1. NM_001024483.1.
XP_005204326.1. XM_005204269.3.
XP_005204327.1. XM_005204270.3.
XP_010801601.1. XM_010803299.2.
UniGeneiBt.20613.

Genome annotation databases

GeneIDi506231.
KEGGibta:506231.

Similar proteinsi

Entry informationi

Entry nameiBCAR3_BOVIN
AccessioniPrimary (citable) accession number: Q58DL5
Secondary accession number(s): Q2KJF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome