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Protein

Breast cancer anti-estrogen resistance protein 3

Gene

BCAR3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an adapter protein and couple activated growth factor receptors to signaling molecules that regulate src kinase activity and promote cell migration.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3
Gene namesi
Name:BCAR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 826825Breast cancer anti-estrogen resistance protein 3PRO_0000230283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei291 – 2911PhosphoserineBy similarity
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei364 – 3641PhosphoserineBy similarity
Modified residuei376 – 3761PhosphoserineBy similarity
Modified residuei472 – 4721PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ58DL5.
PRIDEiQ58DL5.

Interactioni

Subunit structurei

Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055991.

Structurei

3D structure databases

ProteinModelPortaliQ58DL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 253100SH2PROSITE-ProRule annotationAdd
BLAST
Domaini549 – 819271Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi480 – 4834Poly-Asp

Sequence similaritiesi

Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IFQG. Eukaryota.
ENOG410XTJR. LUCA.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiQ58DL5.
OrthoDBiEOG77126R.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR028849. BCAR3.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR14247:SF10. PTHR14247:SF10. 1 hit.
PfamiPF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLVERRAD AYQDVSIHGT
60 70 80 90 100
LPRKKKGPPP IRSCDNFSHV GTLPHSRSPR HHSPLIQDVI QEQPLQDWKG
110 120 130 140 150
EAFTFRDQHL LDPTLEYVKF SKERHVMDRT PERLKKELEE ELLLSSEDLR
160 170 180 190 200
SHAWYHGRIP RQVSENLMQR DGDFLVRDSL SSPGDFVLTC QWKNLPQHFK
210 220 230 240 250
IRRTVVRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP ISQQSGAIIF
260 270 280 290 300
QPVNRTVPLR CLEERYGASS PDRAHEGSLT EGRPDAAKRL SLTVGGTQAR
310 320 330 340 350
EQGLPRGNLL RNKEKSGSQP ACLDHMQDRR ALSLKAHQSE SYLPIGGKLT
360 370 380 390 400
PQSPSVGTSP CPNSPVFRTG SEPTLSPAVV RRVSSDARPG EALRGSDSQL
410 420 430 440 450
CPKPPPKPCK APLLKAPPSP SIWLNSEANY CELNPALAAS YDGASRLPFC
460 470 480 490 500
AQDSYVELLT AKQNGGLGTR NSDTSYLILD DDDRTRPWKP PPAPGDTVGE
510 520 530 540 550
DQDTFVMPLL ETTSSFKPND FESKLLPPEN KPLETSMLKR AKELFTNSDP
560 570 580 590 600
KVIAQHLLSV DCKVARILEV SEEMRKNMGV NSGLELITLP YGHQLRLDII
610 620 630 640 650
ERHNTMAIGI AVDILGCTGS LEDRAATLNK IIQVAVELKD SMGDLYSFSA
660 670 680 690 700
IMKALEMPQI TRLEKTWTAL RHQYTQTAIL YEKQLKPFSK VLHEGRESTC
710 720 730 740 750
VPPNNVSVPL LMPLVTLMER EAVTFEGTDM WEKNDESCEI MLNHLATARL
760 770 780 790 800
MAEAADSYRM NAERILAGFQ PDEEMSEVFK TEFQMRLLWG SKGAQVNQTE
810 820
RYEKFNQILT ALSRKLEPPP VKQMEF
Length:826
Mass (Da):92,765
Last modified:April 4, 2006 - v2
Checksum:i9E5EF3BFF75E9EB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101L → I in AAX46429 (PubMed:16305752).Curated
Sequence conflicti764 – 7641R → K in AAI05367 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021582 mRNA. Translation: AAX46429.1.
BC105366 mRNA. Translation: AAI05367.1.
RefSeqiNP_001019654.1. NM_001024483.1.
XP_005204326.1. XM_005204269.3.
XP_005204327.1. XM_005204270.3.
XP_010801601.1. XM_010803299.2.
UniGeneiBt.20613.

Genome annotation databases

GeneIDi506231.
KEGGibta:506231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021582 mRNA. Translation: AAX46429.1.
BC105366 mRNA. Translation: AAI05367.1.
RefSeqiNP_001019654.1. NM_001024483.1.
XP_005204326.1. XM_005204269.3.
XP_005204327.1. XM_005204270.3.
XP_010801601.1. XM_010803299.2.
UniGeneiBt.20613.

3D structure databases

ProteinModelPortaliQ58DL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055991.

Proteomic databases

PaxDbiQ58DL5.
PRIDEiQ58DL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi506231.
KEGGibta:506231.

Organism-specific databases

CTDi8412.

Phylogenomic databases

eggNOGiENOG410IFQG. Eukaryota.
ENOG410XTJR. LUCA.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiQ58DL5.
OrthoDBiEOG77126R.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR028849. BCAR3.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR14247:SF10. PTHR14247:SF10. 1 hit.
PfamiPF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50009. RASGEF_CAT. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiBCAR3_BOVIN
AccessioniPrimary (citable) accession number: Q58DL5
Secondary accession number(s): Q2KJF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 6, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.