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Protein

Zinc finger protein 205

Gene

ZNF205

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri306 – 32823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 205
Gene namesi
Name:ZNF205
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Zinc finger protein 205PRO_0000254022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki216 – 216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei290 – 2901PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ58DK7.
PRIDEiQ58DK7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007323.

Structurei

3D structure databases

ProteinModelPortaliQ58DK7.
SMRiQ58DK7. Positions 303-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19370KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri306 – 32823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ58DK7.
KOiK09228.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58DK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADDGGIRA AQDKERARET PGHGHSCQEM LSESEGTVPL GEAWESPHIK
60 70 80 90 100
MEPEEPHPEG VSQETRAEGA RGWVPLSQGT KEKVCFLPGG ALPAPQTPVL
110 120 130 140 150
SREGRTRDRQ MAAALLTAWS QMPVTFEDMA LYLSREEWGR LDHTQQSFYR
160 170 180 190 200
EVLQKRSGLS LGFPFSRPFW ASQVQGKGEA PGSSRQLGHE EEEKRGVVEV
210 220 230 240 250
DKEELAASLG ALGDAKSFKS RMGRAQGEAP RCGQRAASGQ NSGPAKDDVQ
260 270 280 290 300
PCPVKEAQLE SAPPDTDLPK TQEGHFPEQP REGGTAAPES SEEGLALDSE
310 320 330 340 350
AGKKTYKCEQ CGKAFSWHSH LVTHRRTHTG EKPYACTDCG KRFGRSSHLI
360 370 380 390 400
QHQIIHTGEK PYTCPSCWKS FSHHSTLIQH QRIHTGEKPY VCDRCAKRFT
410 420 430 440 450
RRSDLVTHQG THTGAKPHKC PICGKCFTQS SALVTHQRTH TGVKPYPCPE
460 470 480 490 500
CGKCFSQRSN LIAHNRTHTG EKPYHCLDCG KSFSHSSHLT AHQRTHRGVR
510 520 530 540 550
PYSCPLCGKS FSRRSNLHRH EKIHTAGPKA LAMLMLGAAG TLAAPPPAPT
Length:550
Mass (Da):60,459
Last modified:April 26, 2005 - v1
Checksum:iC1B14CA37B485DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021590 mRNA. Translation: AAX46437.1.
BC123477 mRNA. Translation: AAI23478.1.
RefSeqiNP_001029645.1. NM_001034473.2.
UniGeneiBt.6062.

Genome annotation databases

GeneIDi514765.
KEGGibta:514765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021590 mRNA. Translation: AAX46437.1.
BC123477 mRNA. Translation: AAI23478.1.
RefSeqiNP_001029645.1. NM_001034473.2.
UniGeneiBt.6062.

3D structure databases

ProteinModelPortaliQ58DK7.
SMRiQ58DK7. Positions 303-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007323.

Proteomic databases

PaxDbiQ58DK7.
PRIDEiQ58DK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514765.
KEGGibta:514765.

Organism-specific databases

CTDi7755.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ58DK7.
KOiK09228.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiZN205_BOVIN
AccessioniPrimary (citable) accession number: Q58DK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.