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Reviewed, UniProtKB/Swiss-Prot Q58DK5 (HEM2_BOVIN)

Last modified January 19, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Delta-aminolevulinic acid dehydratase
      Short name=ALADH
    EC=4.2.1.24
Alternative name(s):
    Porphobilinogen synthase
Gene names
Name: ALAD
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactor

Zinc By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the ALADH family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionLyase
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionporphobilinogen synthase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Delta-aminolevulinic acid dehydratase
PRO_0000328038

Sites

Active site2521 By similarity
Metal binding1221Zinc; catalytic By similarity
Metal binding1241Zinc; catalytic By similarity
Metal binding1321Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58DK5-1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 8BD0E141749B6465

FASTA32936,081
        10         20         30         40         50         60 
MHPQSVLHSG YFHPLLRNWQ TAATSLSASN LIYPIFVTDV PDDKQPIASL PGVARYGVNR 

        70         80         90        100        110        120 
LEEMLKPLVE EGLRCVLIFG VPSRVPKDER GSAADSEDSP AIEAIRLLRK NFPSLLVACD 

       130        140        150        160        170        180 
VCLCPYTSHG HCGLLSENGS FQAEESRQRL AEVALAYAKA GCQVVAPSDM MDGRVEAIKE 

       190        200        210        220        230        240 
ALMAHGFGNR VSVMSYSAKF ASCFYGPFRD AAQSSPAFGD RRCYQLPPGA RGLALRAVDR 

       250        260        270        280        290        300 
DVREGADLLM VKPGTPYLDI VREVKNKHPE LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV 

       310        320 
LEVMTAFRRA GADVIITYYT PQLLQWLKE 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT021592 mRNA. Translation: AAX46439.1.
IPIIPI00712730.
RefSeqNP_001014895.1.
UniGeneBt.37574

3D structure databases

HSSPHSSP built from PDB template 1E51 based on UniProtKB P13716.
SMRQ58DK5. Positions 1-328.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ58DK5.

Genome annotation databases

EnsemblENSBTAT00000000315; ENSBTAP00000000315; ENSBTAG00000000251; Bos taurus. [Genome view]
GeneID510679.
KEGGbta:510679.

Organism-specific databases

CTD510679.

Phylogenomic databases

HOVERGENQ58DK5.
InParanoidQ58DK5.
PhylomeDBQ58DK5.

Enzyme and pathway databases

BRENDA4.2.1.24. 251.

Family and domain databases

InterProIPR001731. 4pyrrol_synth_porphobiln_synth.
IPR013785. Aldolase_TIM.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM2_BOVIN
AccessionPrimary (citable) accession number: Q58DK5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 26, 2005
Last modified: January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents