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Q58DH9

- NAGAB_BOVIN

UniProt

Q58DH9 - NAGAB_BOVIN

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Protein
Alpha-N-acetylgalactosaminidase
Gene
NAGA
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids By similarity.

Catalytic activityi

Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei154 – 1541Substrate By similarity
Active sitei156 – 1561Nucleophile By similarity
Binding sitei188 – 1881Substrate By similarity
Binding sitei213 – 2131Substrate By similarity
Active sitei217 – 2171Proton donor By similarity
Binding sitei217 – 2171Substrate By similarity

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminidase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB
  2. glycolipid catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH27. Glycoside Hydrolase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminidase (EC:3.2.1.49)
Alternative name(s):
Alpha-galactosidase B
Gene namesi
Name:NAGA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 By similarity
Add
BLAST
Chaini18 – 411394Alpha-N-acetylgalactosaminidase
PRO_0000001017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 80 By similarity
Disulfide bondi42 ↔ 49 By similarity
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi127 ↔ 158 By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi187 ↔ 209 By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Modified residuei322 – 3221Phosphoserine By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi385 – 3851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ58DH9.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ58DH9.
SMRiQ58DH9. Positions 18-402.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 792Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68897.
HOGENOMiHOG000161224.
HOVERGENiHBG001989.
InParanoidiQ58DH9.
KOiK01204.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02065. Melibiase. 1 hit.
[Graphical view]
PRINTSiPR00740. GLHYDRLASE27.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00512. ALPHA_GALACTOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DH9-1 [UniParc]FASTAAdd to Basket

« Hide

MLLKTVLLLA LASQVLVLEN GLLRKPPMGW LAWERFRCNI DCSEDPKNCI    50
SEQLFMEMAD RLAQDGWRDL GYVYLNIDDC WIGGRDAKGN LVPDRKRFPH 100
GIAFLADYAH SLGLKLGIYE DLGNFTCMGY PGTTLDKVVQ DAQTFAEWKV 150
DMLKLDGCYS TPQERAEGYP KMAAALNATG RPIAFSCSWP AYEGGLPPKV 200
NYTLLADICN LWRNFDDIQD SWRSVLSVLD WFVTHQDVLQ PIAGPGHWND 250
PDMLLIGNFG LSFEQAQAQM ALWTVLAAPL FMSTDLRTIS AQNMDILQNP 300
LMIKINQDPL GIQGRRILKE KSHIEVYLRP LASEASAIVF FSRRMDMPYH 350
YHSSLARLNF SSSVVYEAQD VYTGDIISGL QDKTNFTVII NPSGVVMWYL 400
YPIRKLEIPQ Q 411
Length:411
Mass (Da):46,533
Last modified:April 26, 2005 - v1
Checksum:i69039FB69B869144
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021618 mRNA. Translation: AAX46465.1.
RefSeqiNP_001039814.1. NM_001046349.1.
UniGeneiBt.57867.

Genome annotation databases

GeneIDi533357.
KEGGibta:533357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021618 mRNA. Translation: AAX46465.1 .
RefSeqi NP_001039814.1. NM_001046349.1.
UniGenei Bt.57867.

3D structure databases

ProteinModelPortali Q58DH9.
SMRi Q58DH9. Positions 18-402.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL5079.

Protein family/group databases

CAZyi GH27. Glycoside Hydrolase Family 27.

Proteomic databases

PRIDEi Q58DH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 533357.
KEGGi bta:533357.

Organism-specific databases

CTDi 4668.

Phylogenomic databases

eggNOGi NOG68897.
HOGENOMi HOG000161224.
HOVERGENi HBG001989.
InParanoidi Q58DH9.
KOi K01204.

Miscellaneous databases

NextBioi 20876014.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02065. Melibiase. 1 hit.
[Graphical view ]
PRINTSi PR00740. GLHYDRLASE27.
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00512. ALPHA_GALACTOSIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNAGAB_BOVIN
AccessioniPrimary (citable) accession number: Q58DH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi