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Q58DH2 (PISD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:PISD
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactor

Pyruvoyl group By similarity.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Subunit structure

Heterodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentMitochondrion
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Phosphatidylserine decarboxylase beta chain
PRO_0000262287
Chain385 – 41632Phosphatidylserine decarboxylase alpha chain
PRO_0000262288

Sites

Site384 – 3852Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue3851Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58DH2 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: B3853F217D5B0EB5

FASTA41647,244
        10         20         30         40         50         60 
MPGKSTRPLP APRPCCAPCP FWSPRLAGMQ GTGSTRSTGS ESWRSWAWTS RPSLLVTGRL 

        70         80         90        100        110        120 
HFPQLALRRR LGQLSCMSKP ALKLRSWPLT VLYYLLPLGA LRPLSRVGWR PVSRVALYKS 

       130        140        150        160        170        180 
VPTRLLSRAW GRLNQVELPH WLRRPVYSLY IWTFGVNMKE AAVEDLHHYR NLSEFFRRKL 

       190        200        210        220        230        240 
KPQARPVCGL HSVISPSDGK ILNFGQVKNC EVEQVKGVTY SLESFLGPRT PSEDLPFPPA 

       250        260        270        280        290        300 
TPHSSFRSQL VTREGNELYH CVIYLAPGDY HCFHSPTDWT VSHRRHFPGS LMSVNPGMAR 

       310        320        330        340        350        360 
WIKELFCHNE RVVLTGDWKH GFFSLTAVGA TNVGSIRIYF DRDLHTNSPR YSKGSYNDFS 

       370        380        390        400        410 
FVTHANKEGI PMRKGEHLGE FNLGSTIVLI FEAPKDFNFR LQAGQKIRFG EALGSL

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT021625 mRNA. Translation: AAX46472.1.
IPIIPI00718616.
RefSeqNP_001019646.1. NM_001024475.1.
UniGeneBt.3992.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ58DH2.

Proteomic databases

PRIDEQ58DH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011848; ENSBTAP00000011848; ENSBTAG00000008998.
GeneID505332.
KEGGbta:505332.

Organism-specific databases

CTD23761.

Phylogenomic databases

eggNOGmaNOG09678.
GeneTreeENSGT00390000013484.
HOVERGENHBG039630.
InParanoidQ58DH2.
PhylomeDBQ58DH2.

Family and domain databases

InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Entry information

Entry namePISD_BOVIN
AccessionPrimary (citable) accession number: Q58DH2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 26, 2005
Last modified: November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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