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Protein

Syndecan-2

Gene

SDC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022928. HS-GAG biosynthesis.
R-BTA-2024096. HS-GAG degradation.
R-BTA-3000170. Syndecan interactions.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
CD_antigen: CD362
Gene namesi
Name:SDC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 148126ExtracellularSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 20233CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 202180Syndecan-2PRO_0000227542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi55 – 551O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi57 – 571O-linked (Xyl...) (heparan sulfate)Sequence analysis
Modified residuei188 – 1881PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1442Cleavage of ectodomainSequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ58DD4.
PRIDEiQ58DD4.

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1. Forms a complex with SDCBP and PDCD6IP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019090.

Structurei

3D structure databases

ProteinModelPortaliQ58DD4.
SMRiQ58DD4. Positions 171-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiQ58DD4.
KOiK16336.
OMAiASASGSX.
OrthoDBiEOG7GJ6G5.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAWILLTW VLVACVSAES RAELTSDKDM YLDNNSIEEA SGVYPIDDDD
60 70 80 90 100
YASASGSGAG EDGESPELTT SRPIPKIPFT STAPRVETTT LSKIQDKIPA
110 120 130 140 150
QTKSPEEIDK EKVHLPDSER KTDPAEEDTN VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF

YA
Length:202
Mass (Da):22,399
Last modified:April 26, 2005 - v1
Checksum:i7E855A0BFFA65B86
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251A → D in AAI12469 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021663 mRNA. Translation: AAX46510.1.
BC112468 mRNA. Translation: AAI12469.1.
RefSeqiNP_001029960.2. NM_001034788.2.
UniGeneiBt.11462.

Genome annotation databases

EnsembliENSBTAT00000019090; ENSBTAP00000019090; ENSBTAG00000014357.
GeneIDi615785.
KEGGibta:615785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021663 mRNA. Translation: AAX46510.1.
BC112468 mRNA. Translation: AAI12469.1.
RefSeqiNP_001029960.2. NM_001034788.2.
UniGeneiBt.11462.

3D structure databases

ProteinModelPortaliQ58DD4.
SMRiQ58DD4. Positions 171-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019090.

Proteomic databases

PaxDbiQ58DD4.
PRIDEiQ58DD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019090; ENSBTAP00000019090; ENSBTAG00000014357.
GeneIDi615785.
KEGGibta:615785.

Organism-specific databases

CTDi6383.

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiQ58DD4.
KOiK16336.
OMAiASASGSX.
OrthoDBiEOG7GJ6G5.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-BTA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-BTA-2022928. HS-GAG biosynthesis.
R-BTA-2024096. HS-GAG degradation.
R-BTA-3000170. Syndecan interactions.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-975634. Retinoid metabolism and transport.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiSDC2_BOVIN
AccessioniPrimary (citable) accession number: Q58DD4
Secondary accession number(s): Q2KIX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.