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Protein

Angiotensin-converting enzyme 2

Gene

ACE2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function (By similarity).By similarity

Catalytic activityi

Angiotensin II + H2O = angiotensin-1-7 + L-phenylalanine.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
  • chlorideBy similarityNote: Binds 1 Cl- ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168ChlorideBy similarity1
Binding sitei272SubstrateBy similarity1
Binding sitei344SubstrateBy similarity1
Binding sitei345Substrate; via carbonyl oxygenBy similarity1
Binding sitei370SubstrateBy similarity1
Metal bindingi373Zinc; catalyticPROSITE-ProRule annotation1
Active sitei374PROSITE-ProRule annotation1
Metal bindingi377Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi401Zinc; catalyticPROSITE-ProRule annotation1
Binding sitei476ChlorideBy similarity1
Binding sitei480ChlorideBy similarity1
Active sitei504PROSITE-ProRule annotation1
Binding sitei514SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Chloride, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-2022377. Metabolism of Angiotensinogen to Angiotensins.

Protein family/group databases

MEROPSiM02.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme 2 (EC:3.4.17.23)
Alternative name(s):
ACE-related carboxypeptidase
Cleaved into the following chain:
Gene namesi
Name:ACE2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 739ExtracellularSequence analysisAdd BLAST722
Transmembranei740 – 760HelicalSequence analysisAdd BLAST21
Topological domaini761 – 804CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002856818 – 804Angiotensin-converting enzyme 2Add BLAST787
ChainiPRO_000029226618 – 707Processed angiotensin-converting enzyme 2Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi343 ↔ 360By similarity
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi529 ↔ 541By similarity
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi659N-linked (GlcNAc...)Sequence analysis1
Glycosylationi689N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ58DD0.
PRIDEiQ58DD0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000034402.

Interactioni

Subunit structurei

Interacts with ITGB1 and the catalytically active form of TMPRSS2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045721.

Structurei

3D structure databases

ProteinModelPortaliQ58DD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 658Essential for cleavage by ADAM17By similarity8
Regioni696 – 715Essential for cleavage by TMPRSS11D and TMPRSS2By similarityAdd BLAST20

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
GeneTreeiENSGT00520000055576.
HOGENOMiHOG000292210.
HOVERGENiHBG000265.
InParanoidiQ58DD0.
OMAiCNPNNPQ.
OrthoDBiEOG091G033S.
TreeFamiTF312861.

Family and domain databases

CDDicd06461. M2_ACE. 1 hit.
InterProiIPR033591. ACE2.
IPR031588. Collectrin_dom.
IPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 2 hits.
PTHR10514:SF24. PTHR10514:SF24. 2 hits.
PfamiPF16959. Collectrin. 1 hit.
PF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSFWLLLS LVAVTAAQST TEEQAKTFLE KFNHEAEDLS YQSSLASWNY
60 70 80 90 100
NTNITDENVQ KMNEARAKWS AFYEEQSRMA KTYSLEEIQN LTLKRQLKAL
110 120 130 140 150
QHSGTSALSA EKSKRLNTIL NKMSTIYSTG KVLDPNTQEC LALEPGLDDI
160 170 180 190 200
MENSRDYNRR LWAWEGWRAE VGKQLRPLYE EYVVLENEMA RANNYEDYGD
210 220 230 240 250
YWRGDYEVTG AGDYDYSRDQ LMKDVERTFA EIKPLYEQLH AYVRAKLMHT
260 270 280 290 300
YPSYISPTGC LPAHLLGDMW GRFWTNLYSL TVPFEHKPSI DVTEKMENQS
310 320 330 340 350
WDAERIFKEA EKFFVSISLP YMTQGFWDNS MLTEPGDGRK VVCHPTAWDL
360 370 380 390 400
GKGDFRIKMC TKVTMDDFLT AHHEMGHIQY DMAYAAQPYL LRNGANEGFH
410 420 430 440 450
EAVGEIMSLS AATPHYLKAL GLLAPDFHED NETEINFLLK QALTIVGTLP
460 470 480 490 500
FTYMLEKWRW MVFKGEIPKQ QWMEKWWEMK REIVGVVEPL PHDETYCDPA
510 520 530 540 550
CLFHVAEDYS FIRYYTRTIY QFQFHEALCK TAKHEGALFK CDISNSTEAG
560 570 580 590 600
QRLLQMLRLG KSEPWTLALE NIVGIKTMDV KPLLNYFEPL FTWLKEQNRN
610 620 630 640 650
SFVGWSTEWT PYSDQSIKVR ISLKSALGEN AYEWNDNEMY LFQSSVAYAM
660 670 680 690 700
RKYFSEARNE TVLFGEDNVW VSDKKPRISF KFFVTSPNNV SDIIPRTEVE
710 720 730 740 750
NAIRLSRDRI NDVFQLDDNS LEFLGIQPTL GPPYEPPVTI WLIIFGVVMG
760 770 780 790 800
VVVIGIVVLI FTGIRNRRKK NQASSEENPY GSVDLNKGEN NSGFQNIDDV

QTSL
Length:804
Mass (Da):93,067
Last modified:April 26, 2005 - v1
Checksum:iE81570A96872A963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021667 mRNA. Translation: AAX46514.1.
RefSeqiXP_005228486.1. XM_005228429.3.
UniGeneiBt.28278.

Genome annotation databases

EnsembliENSBTAT00000048730; ENSBTAP00000045721; ENSBTAG00000034402.
GeneIDi509235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021667 mRNA. Translation: AAX46514.1.
RefSeqiXP_005228486.1. XM_005228429.3.
UniGeneiBt.28278.

3D structure databases

ProteinModelPortaliQ58DD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045721.

Protein family/group databases

MEROPSiM02.006.

Proteomic databases

PaxDbiQ58DD0.
PRIDEiQ58DD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000048730; ENSBTAP00000045721; ENSBTAG00000034402.
GeneIDi509235.

Organism-specific databases

CTDi59272.

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
GeneTreeiENSGT00520000055576.
HOGENOMiHOG000292210.
HOVERGENiHBG000265.
InParanoidiQ58DD0.
OMAiCNPNNPQ.
OrthoDBiEOG091G033S.
TreeFamiTF312861.

Enzyme and pathway databases

ReactomeiR-BTA-2022377. Metabolism of Angiotensinogen to Angiotensins.

Gene expression databases

BgeeiENSBTAG00000034402.

Family and domain databases

CDDicd06461. M2_ACE. 1 hit.
InterProiIPR033591. ACE2.
IPR031588. Collectrin_dom.
IPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 2 hits.
PTHR10514:SF24. PTHR10514:SF24. 2 hits.
PfamiPF16959. Collectrin. 1 hit.
PF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACE2_BOVIN
AccessioniPrimary (citable) accession number: Q58DD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.