Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein 1

Gene

GTPBP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi167 – 1748GTPSequence analysis
Nucleotide bindingi252 – 2565GTPSequence analysis
Nucleotide bindingi308 – 3114GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Gene namesi
Name:GTPBP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669GTP-binding protein 1PRO_0000293472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei47 – 471PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei580 – 5801PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ58DC5.
PRIDEiQ58DC5.

Expressioni

Gene expression databases

ExpressionAtlasiQ58DC5. baseline.

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013635.

Structurei

3D structure databases

ProteinModelPortaliQ58DC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 389232tr-type GPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni167 – 1748G1PROSITE-ProRule annotation
Regioni206 – 2105G2PROSITE-ProRule annotation
Regioni252 – 2554G3PROSITE-ProRule annotation
Regioni308 – 3114G4PROSITE-ProRule annotation
Regioni366 – 3683G5PROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 369Poly-Ala

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiQ58DC5.
OMAiPPGDEAC.
OrthoDBiEOG70KGPM.
TreeFamiTF350446.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58DC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAERSRSPM ESPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQEA GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSTKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLP
610 620 630 640 650
KREEGGPSGG PTVGGPPPGD EACSLGATQL AASSSLQPQP KPSSGGRRRG
660
GQRHKVKSQG ACMTPASGC
Length:669
Mass (Da):72,585
Last modified:July 10, 2007 - v2
Checksum:i0AD3B7B4115F86DE
GO
Isoform 2 (identifier: Q58DC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-603: NNSPMNSKPQQIKMQSTKKGPLPKRE → SPPSPTLHHSSCVQTTGPLSSPPSNY
     604-669: Missing.

Note: No experimental confirmation available.
Show »
Length:603
Mass (Da):65,972
Checksum:i5D9B956C88250C4D
GO

Sequence cautioni

The sequence AAX46519.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei578 – 60326NNSPM…LPKRE → SPPSPTLHHSSCVQTTGPLS SPPSNY in isoform 2. 1 PublicationVSP_026490Add
BLAST
Alternative sequencei604 – 66966Missing in isoform 2. 1 PublicationVSP_026491Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021672 mRNA. Translation: AAX46519.1. Different initiation.
CK833772 mRNA. No translation available.
DV883035 mRNA. No translation available.
RefSeqiNP_001017938.1. NM_001017938.1.
XP_005207379.1. XM_005207322.3. [Q58DC5-1]
UniGeneiBt.37386.

Genome annotation databases

EnsembliENSBTAT00000013635; ENSBTAP00000013635; ENSBTAG00000010324. [Q58DC5-1]
GeneIDi513922.
KEGGibta:513922.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021672 mRNA. Translation: AAX46519.1. Different initiation.
CK833772 mRNA. No translation available.
DV883035 mRNA. No translation available.
RefSeqiNP_001017938.1. NM_001017938.1.
XP_005207379.1. XM_005207322.3. [Q58DC5-1]
UniGeneiBt.37386.

3D structure databases

ProteinModelPortaliQ58DC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013635.

Proteomic databases

PaxDbiQ58DC5.
PRIDEiQ58DC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013635; ENSBTAP00000013635; ENSBTAG00000010324. [Q58DC5-1]
GeneIDi513922.
KEGGibta:513922.

Organism-specific databases

CTDi9567.

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
GeneTreeiENSGT00730000110829.
HOGENOMiHOG000176635.
HOVERGENiHBG004471.
InParanoidiQ58DC5.
OMAiPPGDEAC.
OrthoDBiEOG70KGPM.
TreeFamiTF350446.

Miscellaneous databases

NextBioi20871095.

Gene expression databases

ExpressionAtlasiQ58DC5. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Construction and analysis of a cDNA library generated from intestinal muscle and epithelial tissues of Holstein cattle."
    Baumann R.G., Baldwin R.L., Sonstegard T.S., Van Tassell C.P., Matukumalli L.K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-631 (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 551-669 (ISOFORM 1).

Entry informationi

Entry nameiGTPB1_BOVIN
AccessioniPrimary (citable) accession number: Q58DC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 13, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.