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Q58DB6

- EYA2_BOVIN

UniProt

Q58DB6 - EYA2_BOVIN

Protein

Eyes absent homolog 2

Gene

EYA2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Cofactori

    Binds 1 Mg2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei273 – 2731NucleophileBy similarity
    Metal bindingi273 – 2731MagnesiumBy similarity
    Active sitei275 – 2751Proton donorBy similarity
    Metal bindingi275 – 2751Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi501 – 5011MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB
    2. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW
    2. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    3. histone dephosphorylation Source: UniProtKB
    4. mitochondrial outer membrane permeabilization Source: Ensembl
    5. multicellular organismal development Source: UniProtKB-KW
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. striated muscle tissue development Source: Ensembl
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eyes absent homolog 2 (EC:3.1.3.48)
    Gene namesi
    Name:EYA2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Eyes absent homolog 2PRO_0000244420Add
    BLAST

    Proteomic databases

    PRIDEiQ58DB6.

    Interactioni

    Subunit structurei

    Interacts with DACH2 and SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with CAPN8. Interacts with GNAZ and GNAI2; this precludes interaction with SIX1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58DB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG297494.
    GeneTreeiENSGT00390000008860.
    HOGENOMiHOG000293149.
    HOVERGENiHBG002447.
    InParanoidiQ58DB6.
    KOiK17620.
    OMAiIHSRPNC.
    OrthoDBiEOG7DNNTZ.
    TreeFamiTF319337.

    Family and domain databases

    InterProiIPR028473. EYA2.
    IPR006545. EYA_dom.
    IPR028472. EYA_fam.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PANTHERiPTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF7. PTHR10190:SF7. 1 hit.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01658. EYA-cons_domain. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q58DB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLELLVSASL TVNSDRPGKL KPSRADADVW TLSDREGITT SARSVSQLFA    50
    RPCPRVPPGQ PPSAMAAYSQ TQYSAGIQQA TPYTAYPPPA QAYGIPSYSI 100
    KTEDSLNHSP GQSGFLSYGS SFSTPASGQS PYTYQMHGTA GIYQGANGLT 150
    NAAGFGTVHQ DYPSYPGFPQ SQYSQYYSSS YNPPYVPASS ICPSPLSTST 200
    YVLQEASHNI PSQSSESLGG EYNTHNGPST PAKEGDTDRP PRASDGKLRG 250
    RSKRSSDPSP AGDNEIERVF VWDLDETIII FHSLLTGTFA SRYGKDTTAS 300
    VRIGLMMEEM IFNLADTHLF FNDLEDCDQI HVDDVSSDDN GQDLSTYNFS 350
    ADGFHSSAPG ANLCLGSGVH GGVDWMRKLA FRYRRVKEMY NTYKNNVGGL 400
    IGAPKRETWL QLRAELEALT DLWLTHSLKA LNLINSRPNC VNVLVTTTQL 450
    IPALAKVLLY GLGSVFPIEN IYSATKTGKE SCFERIMQRF GRKAVYIVIG 500
    DGVEEEQGAK KHNMPFWRIS CHADLEALRH ALELEYL 537
    Length:537
    Mass (Da):58,807
    Last modified:April 26, 2005 - v1
    Checksum:i081635FDF8BEE2DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021681 mRNA. Translation: AAX46528.1.
    RefSeqiNP_001030541.1. NM_001035464.1.
    UniGeneiBt.26339.

    Genome annotation databases

    EnsembliENSBTAT00000017737; ENSBTAP00000017737; ENSBTAG00000013336.
    GeneIDi615264.
    KEGGibta:615264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021681 mRNA. Translation: AAX46528.1 .
    RefSeqi NP_001030541.1. NM_001035464.1.
    UniGenei Bt.26339.

    3D structure databases

    ProteinModelPortali Q58DB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017737.

    Proteomic databases

    PRIDEi Q58DB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017737 ; ENSBTAP00000017737 ; ENSBTAG00000013336 .
    GeneIDi 615264.
    KEGGi bta:615264.

    Organism-specific databases

    CTDi 2139.

    Phylogenomic databases

    eggNOGi NOG297494.
    GeneTreei ENSGT00390000008860.
    HOGENOMi HOG000293149.
    HOVERGENi HBG002447.
    InParanoidi Q58DB6.
    KOi K17620.
    OMAi IHSRPNC.
    OrthoDBi EOG7DNNTZ.
    TreeFami TF319337.

    Miscellaneous databases

    NextBioi 20899533.

    Family and domain databases

    InterProi IPR028473. EYA2.
    IPR006545. EYA_dom.
    IPR028472. EYA_fam.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    PANTHERi PTHR10190. PTHR10190. 1 hit.
    PTHR10190:SF7. PTHR10190:SF7. 1 hit.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01658. EYA-cons_domain. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiEYA2_BOVIN
    AccessioniPrimary (citable) accession number: Q58DB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3