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Protein

Palmitoyltransferase ZDHHC9

Gene

ZDHHC9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC9 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 9
Short name:
DHHC-9
Gene namesi
Name:ZDHHC9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 63LumenalSequence analysis7
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 183CytoplasmicSequence analysisAdd BLAST99
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228LumenalSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 363CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128791 – 363Palmitoyltransferase ZDHHC9Add BLAST363

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ58DA8.
PRIDEiQ58DA8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015354.

Interactioni

Subunit structurei

Interacts with GOLGA7.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 189DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiQ58DA8.
KOiK16675.
OMAiRYFYLFT.
OrthoDBiEOG091G0BOW.
TreeFamiTF312923.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58DA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMVVRKKV TRKWEKLPGR NTFCCDGRVM MARQKGIFYL TLFLILGTCT
60 70 80 90 100
LFFAFECRYL AVQLSPAIPV FAAMLFLFSM ATLLRTSFSD PGVIPRALPD
110 120 130 140 150
EAAFIEMEIE ATNGAVPQGQ RPPPRIKNFQ INNQIVKLKY CYTCKIFRPP
160 170 180 190 200
RASHCSICDN CVERFDHHCP WVGNCVGKRN YRYFYLFILS LSLLTIYVFA
210 220 230 240 250
FNIVYVALKS LKIGFLETLK ETPGTVLEVL ICFFTLWSVV GLTGFHTFLV
260 270 280 290 300
ALNQTTNEDI KGSWTGKNRV QNPYSHGNIV KNCCEVLCGP LPPSVLDRRG
310 320 330 340 350
ILPLEESGSR PPSTQEASTS LLPQGPAPID HLSNEMPEDT STPEEMPPPE
360
PPEPPQEVTE AEK
Length:363
Mass (Da):40,826
Last modified:April 26, 2005 - v1
Checksum:i6A6651A7F8813322
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti281K → E in AAI05326 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021689 mRNA. Translation: AAX46536.1.
BC105325 mRNA. Translation: AAI05326.1.
RefSeqiNP_001029733.2. NM_001034561.2.
XP_005227547.1. XM_005227490.2.
XP_005227548.1. XM_005227491.2.
UniGeneiBt.32445.

Genome annotation databases

EnsembliENSBTAT00000020418; ENSBTAP00000020418; ENSBTAG00000015354.
ENSBTAT00000048680; ENSBTAP00000045675; ENSBTAG00000015354.
GeneIDi527885.
KEGGibta:527885.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDHC9_BOVIN
AccessioniPrimary (citable) accession number: Q58DA8
Secondary accession number(s): Q2KJI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families