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Reviewed, UniProtKB/Swiss-Prot Q58DA7 (GLRX3_BOVIN)

Last modified June 16, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutaredoxin-3
Alternative name(s):
    Thioredoxin-like protein 2
Gene names
Name: GLRX3
Synonyms: TXNL2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May play a role in regulating the function of the thioredoxin system By similarity.

Subunit structure

Interacts weakly with PKC-theta By similarity.

Subcellular location

Cytoplasm › cell cortex By similarity. Note: Under the plasma membrane. After PMA stimulation, GLRX3/TXNL2 and PRKCQ/PKC-theta translocate to a more extended submembrane area By similarity.

Domain

The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.

Sequence similarities

Contains 2 glutaredoxin domains.

Contains 1 thioredoxin domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   PTMAcetylation
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

protein disulfide oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 334333Glutaredoxin-3
PRO_0000239988

Regions

Domain2 – 116115Thioredoxin
Domain145 – 23591Glutaredoxin 1
Domain236 – 33499Glutaredoxin 2

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict31G → A in AAI33429. Ref.2
Sequence conflict181S → A in AAI33429. Ref.2
Sequence conflict3341N → NQ in AAI33429. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q58DA7-1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: BFC5136B72EB47FB

FASTA33437,298
        10         20         30         40         50         60 
MAGGAAEAAA AVVEVGSSGQ FEELLRLRAK SLLVVHFWAP WAPQCAQMND VMAELAKEHQ 

        70         80         90        100        110        120 
QVSFVKLEAE AVPEVSEKYE ISSVPTFLFF KNSQKIDRLD GAHAPELTKK VQRHASSGSF 

       130        140        150        160        170        180 
SPSGSEHPKE DLSLRLKKLT HAAPCMLFMK GTPQEPRCGF SKQMVEILNK HNIQFSSFDI 

       190        200        210        220        230        240 
FSDEEVRQGL KTYSSWPTYP QLYVSGELIG GLDIIKELEA SKELDTICPK APKLEERLKV 

       250        260        270        280        290        300 
LTNKASVMLF MKGNKQEAKC GFSRQILEIL NSTGIEYETF DILEDEEVRQ GLKAYSNWPT 

       310        320        330 
YPQLYVKGEL VGGLDIVKEL KENGELLPIL KGEN

« Hide

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

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Cross-references

Sequence databases

BT021690 mRNA. Translation: AAX46537.1.
BC133428 mRNA. Translation: AAI33429.1.
IPIIPI00700641.
RefSeqNP_001030273.1.
UniGeneBt.55799

3D structure databases

SMRQ58DA7. Positions 17-121, 238-334.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000005027. Bos taurus. [Contig view]
GeneID511528.
KEGGbta:511528.

Phylogenomic databases

HOVERGENQ58DA7.

Family and domain databases

InterProIPR002109. Glutaredoxin.
IPR004480. Glutredox-rel.
IPR017936. Thioredoxin-like.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 3 hits.
PANTHERPTHR10293. Glutredox-rel. 1 hit.
PfamPF00462. Glutaredoxin. 2 hits.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00365. Glutredox-rel. 2 hits.
PROSITEPS51354. GLUTAREDOXIN_2. 2 hits.
PS00194. THIOREDOXIN_1. False negative.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLRX3_BOVIN
AccessionPrimary (citable) accession number: Q58DA7
Secondary accession number(s): A3KMZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: April 26, 2005
Last modified: June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents