Q58D85 (PAR3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteinase-activated receptor 3
Short name=PAR-3

Alternative name(s):
Coagulation factor II receptor-like 2
Thrombin receptor-like 2

Gene names

Name:	F2RL2
Synonyms:	PAR3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis By similarity.
Subunit structure	Interacts with INSC/inscuteable and GPSM2 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Blood coagulation Hemostasis
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	thrombin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 38	19	Removed for receptor activation By similarity		PRO_0000245016
	Chain	39 – 377	339	Proteinase-activated receptor 3		PRO_0000245017
Regions
	Topological domain	39 – 94	56	Extracellular Potential
	Transmembrane	95 – 120	26	Helical; Name=1; Potential
	Topological domain	121 – 127	7	Cytoplasmic Potential
	Transmembrane	128 – 147	20	Helical; Name=2; Potential
	Topological domain	148 – 166	19	Extracellular Potential
	Transmembrane	167 – 188	22	Helical; Name=3; Potential
	Topological domain	189 – 205	17	Cytoplasmic Potential
	Transmembrane	206 – 229	24	Helical; Name=4; Potential
	Topological domain	230 – 259	30	Extracellular Potential
	Transmembrane	260 – 279	20	Helical; Name=5; Potential
	Topological domain	280 – 296	17	Cytoplasmic Potential
	Transmembrane	297 – 321	25	Helical; Name=6; Potential
	Topological domain	322 – 335	14	Extracellular Potential
	Transmembrane	336 – 360	25	Helical; Name=7; Potential
	Topological domain	361 – 377	17	Cytoplasmic Potential
Sites
	Site	38 – 39	2	Cleavage; by thrombin By similarity
Amino acid modifications
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Disulfide bond	165 ↔ 244		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58D85 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: ECCA672ED8FE445D	FASTA	377	43,009
	10 20 30 40 50 60 MRAAIFAAIG ALLLSPASCQ SGMEYDADNL AKPTLSIKTF RGAPQNSFEE FPLSAIEGWT 70 80 90 100 110 120 GTTKTVKIKC PEELDSNLHV NNATMGYLSS PLSTKLIPAI YILVFAVGMP ANAVTLWMLF 130 140 150 160 170 180 RTRTIRMTIF YTNLAIADFL FCVTLPFRIA YHLNGNNWVF GEVMCRATTV IFYGNMYCSI 190 200 210 220 230 240 LLLACISINR YLAIVHPFTY RGLPKRTYAL LTCGLVWTTV FLYMLPFFIL KQEYYLVQQD 250 260 270 280 290 300 ITTCHDVHNT CESSSPFQLY YFISLAFFGF LIPFLVIIYC YTAIIWTLNA KDRRWLWYIK 310 320 330 340 350 360 ASLLTFVIFT ICFAPSNIIL IIHHANYYYS NTDALYFVYL IALCLGSLNS CLDPFLYFLM 370 SKITDHSTAY LTMVKLS

References

[1]

"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT021712 mRNA. Translation: AAX46559.1.
IPI	IPI00693014.
UniGene	Bt.24447.
3D structure databases
ProteinModelPortal	Q58D85.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG146611.
HOGENOM	HOG000116291.
HOVERGEN	HBG105658.
InParanoid	Q58D85.
OrthoDB	EOG4NS3CG.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003943. Prot_act_rcpt_3. IPR003912. Protea_act_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01428. PROTEASEAR. PR01429. PROTEASEAR3.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PAR3_BOVIN

Accession

Primary (citable) accession number: Q58D85

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program