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Q58D84

- FSTL1_BOVIN

UniProt

Q58D84 - FSTL1_BOVIN

Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_211837. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    Gene namesi
    Name:FSTL1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 307288Follistatin-related protein 1PRO_0000318092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 83PROSITE-ProRule annotation
    Disulfide bondi57 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi65 ↔ 97PROSITE-ProRule annotation
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ58D84.

    Interactioni

    Subunit structurei

    Interacts with SCN10A.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000029886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58D84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 5224Follistatin-likeAdd
    BLAST
    Domaini47 – 9953Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini143 – 17735EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 22736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini232 – 28655VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG148907.
    GeneTreeiENSGT00530000063333.
    HOGENOMiHOG000007780.
    HOVERGENiHBG051665.
    InParanoidiQ58D84.
    OMAiRGLCIDA.
    OrthoDBiEOG7WT427.
    TreeFamiTF106409.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58D84-1 [UniParc]FASTAAdd to Basket

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    MMWRRWLALA LVAVAWVHAE EQVRSKSKIC ANVFCGAGRE CAVTEKGEPT    50
    CLCIEQCKPH KRPVCGSNGK TYLNHCELHR DACLTGSKIQ VDYDGHCKEK 100
    KSVSPSASPV VCYQSNRDEL RRRIIQWLEA EIIPDGWFSK GSNYSEILDK 150
    YFKNFDNGDS RLDSSEFLKF VEQNETAINI TTYADQENNK LLRGLCVDAL 200
    IELSDENADW KLSFQEFLKC LNPSFNPPEK KCALEDETYA DGAETEVDCN 250
    RCVCACGNWV CTAMTCDGKN QKGAQTQAEE EMTRYVQELQ KHQETAEKSK 300
    RVSTKEI 307
    Length:307
    Mass (Da):34,856
    Last modified:April 26, 2005 - v1
    Checksum:iA4A8D1CE4F519A9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114758 mRNA. Translation: AAI14759.1.
    BT021713 mRNA. Translation: AAX46560.1.
    RefSeqiNP_001017950.1. NM_001017950.2.
    XP_005200261.1. XM_005200204.1.
    UniGeneiBt.89210.

    Genome annotation databases

    EnsembliENSBTAT00000029891; ENSBTAP00000029886; ENSBTAG00000022155.
    GeneIDi101909195.
    534482.
    KEGGibta:101909195.
    bta:534482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC114758 mRNA. Translation: AAI14759.1 .
    BT021713 mRNA. Translation: AAX46560.1 .
    RefSeqi NP_001017950.1. NM_001017950.2.
    XP_005200261.1. XM_005200204.1.
    UniGenei Bt.89210.

    3D structure databases

    ProteinModelPortali Q58D84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000029886.

    Proteomic databases

    PRIDEi Q58D84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000029891 ; ENSBTAP00000029886 ; ENSBTAG00000022155 .
    GeneIDi 101909195.
    534482.
    KEGGi bta:101909195.
    bta:534482.

    Organism-specific databases

    CTDi 11167.

    Phylogenomic databases

    eggNOGi NOG148907.
    GeneTreei ENSGT00530000063333.
    HOGENOMi HOG000007780.
    HOVERGENi HBG051665.
    InParanoidi Q58D84.
    OMAi RGLCIDA.
    OrthoDBi EOG7WT427.
    TreeFami TF106409.

    Enzyme and pathway databases

    Reactomei REACT_211837. Signaling by BMP.

    Miscellaneous databases

    NextBioi 20876413.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Uterus.

    Entry informationi

    Entry nameiFSTL1_BOVIN
    AccessioniPrimary (citable) accession number: Q58D84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3