Q58D84 (FSTL1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Follistatin-related protein 1

Alternative name(s):
Follistatin-like protein 1

Gene names

Name:

FSTL1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.
Subunit structure	Interacts with SCN10A By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 307	288	Follistatin-related protein 1		PRO_0000318092
Regions
	Domain	29 – 52	24	Follistatin-like
	Domain	47 – 99	53	Kazal-like
	Domain	143 – 177	35	EF-hand 1
	Domain	192 – 227	36	EF-hand 2
	Domain	232 – 286	55	VWFC
Amino acid modifications
	Glycosylation	143	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Disulfide bond	53 ↔ 83		By similarity
	Disulfide bond	57 ↔ 76		By similarity
	Disulfide bond	65 ↔ 97		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58D84 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A4A8D1CE4F519A9F	FASTA	307	34,856
	10 20 30 40 50 60 MMWRRWLALA LVAVAWVHAE EQVRSKSKIC ANVFCGAGRE CAVTEKGEPT CLCIEQCKPH 70 80 90 100 110 120 KRPVCGSNGK TYLNHCELHR DACLTGSKIQ VDYDGHCKEK KSVSPSASPV VCYQSNRDEL 130 140 150 160 170 180 RRRIIQWLEA EIIPDGWFSK GSNYSEILDK YFKNFDNGDS RLDSSEFLKF VEQNETAINI 190 200 210 220 230 240 TTYADQENNK LLRGLCVDAL IELSDENADW KLSFQEFLKC LNPSFNPPEK KCALEDETYA 250 260 270 280 290 300 DGAETEVDCN RCVCACGNWV CTAMTCDGKN QKGAQTQAEE EMTRYVQELQ KHQETAEKSK RVSTKEI

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC114758 mRNA. Translation: AAI14759.1. BT021713 mRNA. Translation: AAX46560.1.
IPI	IPI00707467.
RefSeq	NP_001017950.1. NM_001017950.2.
UniGene	Bt.89210.
3D structure databases
HSSP	HSSP built from PDB template 1LR7 based on UniProtKB P21674.
ProteinModelPortal	Q58D84.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000029886.
Proteomic databases
PRIDE	Q58D84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000029891; ENSBTAP00000029886; ENSBTAG00000022155.
GeneID	534482.
KEGG	bta:534482.
Organism-specific databases
CTD	11167.
Phylogenomic databases
eggNOG	NOG148907.
GeneTree	ENSGT00530000063333.
HOGENOM	HOG000007780.
HOVERGEN	HBG051665.
InParanoid	Q58D84.
OMA	GFNPPEK.
OrthoDB	EOG4J3WHG.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR003645. Fol_N. IPR015369. Follistatin/Osteonectin_EGF. IPR002350. Kazal_dom. [Graphical view]
Pfam	PF09289. FOLN. 1 hit. PF07648. Kazal_2. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. SM00274. FOLN. 1 hit. SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 2 hits. PS51465. KAZAL_2. 1 hit. PS01208. VWFC_1. False negative. PS50184. VWFC_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20876413.

Entry information

Entry name

FSTL1_BOVIN

Accession

Primary (citable) accession number: Q58D84

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program