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Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. response to starvation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_310911. Signaling by BMP.

Protein family/group databases

MEROPSiI01.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:FSTL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 1

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 307288Follistatin-related protein 1PRO_0000318092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 83PROSITE-ProRule annotation
Disulfide bondi57 ↔ 76PROSITE-ProRule annotation
Disulfide bondi65 ↔ 97PROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ58D84.

Interactioni

Subunit structurei

Interacts with SCN10A.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029886.

Structurei

3D structure databases

ProteinModelPortaliQ58D84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 5224Follistatin-likeAdd
BLAST
Domaini47 – 9953Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini143 – 17735EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 22736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini232 – 28655VWFCAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG148907.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ58D84.
OMAiWVHAEEE.
OrthoDBiEOG7WT427.
TreeFamiTF106409.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58D84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWRRWLALA LVAVAWVHAE EQVRSKSKIC ANVFCGAGRE CAVTEKGEPT
60 70 80 90 100
CLCIEQCKPH KRPVCGSNGK TYLNHCELHR DACLTGSKIQ VDYDGHCKEK
110 120 130 140 150
KSVSPSASPV VCYQSNRDEL RRRIIQWLEA EIIPDGWFSK GSNYSEILDK
160 170 180 190 200
YFKNFDNGDS RLDSSEFLKF VEQNETAINI TTYADQENNK LLRGLCVDAL
210 220 230 240 250
IELSDENADW KLSFQEFLKC LNPSFNPPEK KCALEDETYA DGAETEVDCN
260 270 280 290 300
RCVCACGNWV CTAMTCDGKN QKGAQTQAEE EMTRYVQELQ KHQETAEKSK

RVSTKEI
Length:307
Mass (Da):34,856
Last modified:April 25, 2005 - v1
Checksum:iA4A8D1CE4F519A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114758 mRNA. Translation: AAI14759.1.
BT021713 mRNA. Translation: AAX46560.1.
RefSeqiNP_001017950.1. NM_001017950.2.
XP_005200261.1. XM_005200204.1.
UniGeneiBt.89210.

Genome annotation databases

EnsembliENSBTAT00000029891; ENSBTAP00000029886; ENSBTAG00000022155.
GeneIDi101909195.
534482.
KEGGibta:101909195.
bta:534482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114758 mRNA. Translation: AAI14759.1.
BT021713 mRNA. Translation: AAX46560.1.
RefSeqiNP_001017950.1. NM_001017950.2.
XP_005200261.1. XM_005200204.1.
UniGeneiBt.89210.

3D structure databases

ProteinModelPortaliQ58D84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029886.

Protein family/group databases

MEROPSiI01.967.

Proteomic databases

PRIDEiQ58D84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029891; ENSBTAP00000029886; ENSBTAG00000022155.
GeneIDi101909195.
534482.
KEGGibta:101909195.
bta:534482.

Organism-specific databases

CTDi11167.

Phylogenomic databases

eggNOGiNOG148907.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ58D84.
OMAiWVHAEEE.
OrthoDBiEOG7WT427.
TreeFamiTF106409.

Enzyme and pathway databases

ReactomeiREACT_310911. Signaling by BMP.

Miscellaneous databases

NextBioi20876413.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiFSTL1_BOVIN
AccessioniPrimary (citable) accession number: Q58D84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2008
Last sequence update: April 25, 2005
Last modified: March 31, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.