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Q58D84 (FSTL1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene names
Name:FSTL1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.

Subunit structure

Interacts with SCN10A By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 follistatin-like domain.

Contains 1 Kazal-like domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandHeparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 307288Follistatin-related protein 1
PRO_0000318092

Regions

Domain29 – 5224Follistatin-like
Domain47 – 9953Kazal-like
Domain143 – 17735EF-hand 1
Domain192 – 22736EF-hand 2
Domain232 – 28655VWFC

Amino acid modifications

Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 83 By similarity
Disulfide bond57 ↔ 76 By similarity
Disulfide bond65 ↔ 97 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58D84 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: A4A8D1CE4F519A9F

FASTA30734,856
        10         20         30         40         50         60 
MMWRRWLALA LVAVAWVHAE EQVRSKSKIC ANVFCGAGRE CAVTEKGEPT CLCIEQCKPH 

        70         80         90        100        110        120 
KRPVCGSNGK TYLNHCELHR DACLTGSKIQ VDYDGHCKEK KSVSPSASPV VCYQSNRDEL 

       130        140        150        160        170        180 
RRRIIQWLEA EIIPDGWFSK GSNYSEILDK YFKNFDNGDS RLDSSEFLKF VEQNETAINI 

       190        200        210        220        230        240 
TTYADQENNK LLRGLCVDAL IELSDENADW KLSFQEFLKC LNPSFNPPEK KCALEDETYA 

       250        260        270        280        290        300 
DGAETEVDCN RCVCACGNWV CTAMTCDGKN QKGAQTQAEE EMTRYVQELQ KHQETAEKSK 


RVSTKEI 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC114758 mRNA. Translation: AAI14759.1.
BT021713 mRNA. Translation: AAX46560.1.
RefSeqNP_001017950.1. NM_001017950.2.
XP_005200261.1. XM_005200204.1.
UniGeneBt.89210.

3D structure databases

ProteinModelPortalQ58D84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000029886.

Proteomic databases

PRIDEQ58D84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000029891; ENSBTAP00000029886; ENSBTAG00000022155.
GeneID101909195.
534482.
KEGGbta:101909195.
bta:534482.

Organism-specific databases

CTD11167.

Phylogenomic databases

eggNOGNOG148907.
GeneTreeENSGT00530000063333.
HOGENOMHOG000007780.
HOVERGENHBG051665.
InParanoidQ58D84.
OMARGLCIDA.
OrthoDBEOG7WT427.
TreeFamTF106409.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876413.

Entry information

Entry nameFSTL1_BOVIN
AccessionPrimary (citable) accession number: Q58D84
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families