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Protein

Developmentally-regulated GTP-binding protein 2

Gene

DRG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cell proliferation, differentiation and death.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:DRG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:28209 DRG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002615881 – 364Developmentally-regulated GTP-binding protein 2Add BLAST364

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ58D56
PRIDEiQ58D56

Expressioni

Gene expression databases

BgeeiENSBTAG00000006517

Interactioni

Subunit structurei

Interacts with RWDD1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008544

Structurei

3D structure databases

ProteinModelPortaliQ58D56
SMRiQ58D56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075059
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiQ58D56
KOiK06944
OMAiMIREDIT
OrthoDBiEOG091G0A12
TreeFamiTF105706

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

Q58D56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSSSS
60 70 80 90 100
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI
110 120 130 140 150
PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVVIMMLDAT
160 170 180 190 200
KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE
210 220 230 240 250
KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ
260 270 280 290 300
ISMEEVDRLA RKPDSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT
360
HTMEHEDVIQ IVKK
Length:364
Mass (Da):40,749
Last modified:April 26, 2005 - v1
Checksum:iCBE113D597264737
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021741 mRNA Translation: AAX46588.1
RefSeqiNP_001014865.1, NM_001014865.1
UniGeneiBt.3019

Genome annotation databases

EnsembliENSBTAT00000008544; ENSBTAP00000008544; ENSBTAG00000006517
GeneIDi507472
KEGGibta:507472

Similar proteinsi

Entry informationi

Entry nameiDRG2_BOVIN
AccessioniPrimary (citable) accession number: Q58D56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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