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Protein

Developmentally-regulated GTP-binding protein 2

Gene

DRG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell proliferation, differentiation and death.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768GTPPROSITE-ProRule annotation
Nucleotide bindingi115 – 1195GTPPROSITE-ProRule annotation
Nucleotide bindingi246 – 2494GTPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:DRG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Developmentally-regulated GTP-binding protein 2PRO_0000261588Add
BLAST

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ58D56.
PRIDEiQ58D56.

Interactioni

Subunit structurei

Interacts with RWDD1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008544.

Structurei

3D structure databases

ProteinModelPortaliQ58D56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 288226OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075059.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ58D56.
KOiK06944.
OMAiHRKYIKC.
OrthoDBiEOG7PZRXJ.
TreeFamiTF105706.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58D56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSSSS
60 70 80 90 100
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI
110 120 130 140 150
PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVVIMMLDAT
160 170 180 190 200
KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE
210 220 230 240 250
KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ
260 270 280 290 300
ISMEEVDRLA RKPDSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT
360
HTMEHEDVIQ IVKK
Length:364
Mass (Da):40,749
Last modified:April 26, 2005 - v1
Checksum:iCBE113D597264737
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021741 mRNA. Translation: AAX46588.1.
RefSeqiNP_001014865.1. NM_001014865.1.
UniGeneiBt.3019.

Genome annotation databases

EnsembliENSBTAT00000008544; ENSBTAP00000008544; ENSBTAG00000006517.
GeneIDi507472.
KEGGibta:507472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021741 mRNA. Translation: AAX46588.1.
RefSeqiNP_001014865.1. NM_001014865.1.
UniGeneiBt.3019.

3D structure databases

ProteinModelPortaliQ58D56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008544.

Proteomic databases

PaxDbiQ58D56.
PRIDEiQ58D56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008544; ENSBTAP00000008544; ENSBTAG00000006517.
GeneIDi507472.
KEGGibta:507472.

Organism-specific databases

CTDi1819.

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075059.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ58D56.
KOiK06944.
OMAiHRKYIKC.
OrthoDBiEOG7PZRXJ.
TreeFamiTF105706.

Miscellaneous databases

NextBioi20868074.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDRG2_BOVIN
AccessioniPrimary (citable) accession number: Q58D56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.