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Q58D55

- BGAL_BOVIN

UniProt

Q58D55 - BGAL_BOVIN

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Protein

Beta-galactosidase

Gene

GLB1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871Proton donorSequence Analysis
Active sitei267 – 2671NucleophileSequence Analysis

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:GLB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 275By similarityPRO_0000283035
Chaini28 – 653626Beta-galactosidasePRO_0000283036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ58D55.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ58D55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ58D55.
KOiK12309.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58D55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGVVRLLAL LLVPLLLGSA RGLHNATQRT FQIDYRRNRF LKDGQPFRYI
60 70 80 90 100
SGSIHYFRVP RFYWKDRLLK MKMAGLNAIQ TYVAWNFHEL QPGRYNFSGD
110 120 130 140 150
HDVEHFIQLA HELGLLVILR PGPYICAEWD MGGLPAWLLE KKSIVLRSSD
160 170 180 190 200
PDYLAAVDKW LGVLLPKMRP LLYKNGGPII TVQVENEYGS YLSCDYDYLR
210 220 230 240 250
FLQKRFHDHL GEDVLLFTTD GVNERLLQCG ALQGLYATVD FSPGTNLTAA
260 270 280 290 300
FMLQRKFEPT GPLVNSEFYT GWLDHWGQRH STVSSKAVAF TLHDMLALGA
310 320 330 340 350
NVNMYMFIGG TNFAYWNGAN IPYQPQPTSY DYDAPLSEAG DLTEKYFALR
360 370 380 390 400
DIIQKFAKVP EGPIPPSTPK FAYGKVALNK LKTVEDALNI LCPSGPIKSV
410 420 430 440 450
YPLTFIDVKQ YFGFVLYRTM LPEDCSDPTP LSSPLSGVHD RAYVSVNGVA
460 470 480 490 500
QGILERESVI TLNITGKAGA TLDLLVENMG RVNYGSSIND FKGLVSNLTL
510 520 530 540 550
GSKILTNWEI FPLDMEDAVR SHLGTWGGRD RGYHNKARAH SPPTYALPTF
560 570 580 590 600
YVGNFTIPSG IADLPQDTFI QFPGWTKGQV WINGFNLGRY WPVRGPQMTL
610 620 630 640 650
FVPQHILVTS TPNTIVVLEL EHAPCQDGGP ELCTVEFVDK PVFRTVQTHR

HAN
Length:653
Mass (Da):73,413
Last modified:April 26, 2005 - v1
Checksum:i37ED2284A4EB4F97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB325580 mRNA. Translation: BAF64285.1.
BT021742 mRNA. Translation: AAX46589.1.
RefSeqiNP_001030215.1. NM_001035043.1.
UniGeneiBt.6127.

Genome annotation databases

GeneIDi507188.
KEGGibta:507188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB325580 mRNA. Translation: BAF64285.1 .
BT021742 mRNA. Translation: AAX46589.1 .
RefSeqi NP_001030215.1. NM_001035043.1.
UniGenei Bt.6127.

3D structure databases

ProteinModelPortali Q58D55.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q58D55.
ChEMBLi CHEMBL3482.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Proteomic databases

PRIDEi Q58D55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 507188.
KEGGi bta:507188.

Organism-specific databases

CTDi 2720.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000221607.
HOVERGENi HBG004841.
InParanoidi Q58D55.
KOi K12309.

Miscellaneous databases

NextBioi 20867945.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of lysosomal beta-galactosidase from bovine liver."
    Satoh Y., Yajima A., Uda Y.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBGAL_BOVIN
AccessioniPrimary (citable) accession number: Q58D55
Secondary accession number(s): A5LIP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3