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Q58D55

- BGAL_BOVIN

UniProt

Q58D55 - BGAL_BOVIN

Protein

Beta-galactosidase

Gene

GLB1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei187 – 1871Proton donorSequence Analysis
    Active sitei267 – 2671NucleophileSequence Analysis

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH35. Glycoside Hydrolase Family 35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Alternative name(s):
    Acid beta-galactosidase
    Short name:
    Lactase
    Gene namesi
    Name:GLB1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 275By similarityPRO_0000283035
    Chaini28 – 653626Beta-galactosidasePRO_0000283036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiQ58D55.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ58D55.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    HOGENOMiHOG000221607.
    HOVERGENiHBG004841.
    InParanoidiQ58D55.
    KOiK12309.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006336. B-gal. 1 hit.
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58D55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGVVRLLAL LLVPLLLGSA RGLHNATQRT FQIDYRRNRF LKDGQPFRYI    50
    SGSIHYFRVP RFYWKDRLLK MKMAGLNAIQ TYVAWNFHEL QPGRYNFSGD 100
    HDVEHFIQLA HELGLLVILR PGPYICAEWD MGGLPAWLLE KKSIVLRSSD 150
    PDYLAAVDKW LGVLLPKMRP LLYKNGGPII TVQVENEYGS YLSCDYDYLR 200
    FLQKRFHDHL GEDVLLFTTD GVNERLLQCG ALQGLYATVD FSPGTNLTAA 250
    FMLQRKFEPT GPLVNSEFYT GWLDHWGQRH STVSSKAVAF TLHDMLALGA 300
    NVNMYMFIGG TNFAYWNGAN IPYQPQPTSY DYDAPLSEAG DLTEKYFALR 350
    DIIQKFAKVP EGPIPPSTPK FAYGKVALNK LKTVEDALNI LCPSGPIKSV 400
    YPLTFIDVKQ YFGFVLYRTM LPEDCSDPTP LSSPLSGVHD RAYVSVNGVA 450
    QGILERESVI TLNITGKAGA TLDLLVENMG RVNYGSSIND FKGLVSNLTL 500
    GSKILTNWEI FPLDMEDAVR SHLGTWGGRD RGYHNKARAH SPPTYALPTF 550
    YVGNFTIPSG IADLPQDTFI QFPGWTKGQV WINGFNLGRY WPVRGPQMTL 600
    FVPQHILVTS TPNTIVVLEL EHAPCQDGGP ELCTVEFVDK PVFRTVQTHR 650
    HAN 653
    Length:653
    Mass (Da):73,413
    Last modified:April 26, 2005 - v1
    Checksum:i37ED2284A4EB4F97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB325580 mRNA. Translation: BAF64285.1.
    BT021742 mRNA. Translation: AAX46589.1.
    RefSeqiNP_001030215.1. NM_001035043.1.
    UniGeneiBt.6127.

    Genome annotation databases

    GeneIDi507188.
    KEGGibta:507188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB325580 mRNA. Translation: BAF64285.1 .
    BT021742 mRNA. Translation: AAX46589.1 .
    RefSeqi NP_001030215.1. NM_001035043.1.
    UniGenei Bt.6127.

    3D structure databases

    ProteinModelPortali Q58D55.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q58D55.
    ChEMBLi CHEMBL3482.

    Protein family/group databases

    CAZyi GH35. Glycoside Hydrolase Family 35.

    Proteomic databases

    PRIDEi Q58D55.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 507188.
    KEGGi bta:507188.

    Organism-specific databases

    CTDi 2720.

    Phylogenomic databases

    eggNOGi COG1874.
    HOGENOMi HOG000221607.
    HOVERGENi HBG004841.
    InParanoidi Q58D55.
    KOi K12309.

    Miscellaneous databases

    NextBioi 20867945.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006336. B-gal. 1 hit.
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of lysosomal beta-galactosidase from bovine liver."
      Satoh Y., Yajima A., Uda Y.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiBGAL_BOVIN
    AccessioniPrimary (citable) accession number: Q58D55
    Secondary accession number(s): A5LIP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3