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Protein

Beta-galactosidase

Gene

GLB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei186SubstrateBy similarity1
Active sitei187Proton donorBy similarity1
Active sitei267NucleophileBy similarity1
Binding sitei332SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23By similarity)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:GLB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000028303523 – 27By similarity5
ChainiPRO_000028303628 – 653Beta-galactosidaseAdd BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi194 ↔ 229By similarity
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 633By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ58D55
PRIDEiQ58D55

Interactioni

Subunit structurei

Homodimer. May form higher multimers.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020296

Chemistry databases

BindingDBiQ58D55

Structurei

3D structure databases

ProteinModelPortaliQ58D55
SMRiQ58D55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496 Eukaryota
COG1874 LUCA
HOGENOMiHOG000221607
HOVERGENiHBG004841
InParanoidiQ58D55
KOiK12309

Family and domain databases

Gene3Di2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR026283 B-gal_1-like
IPR025300 BetaGal_jelly_roll_dom
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR019801 Glyco_hydro_35_CS
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF13364 BetaGal_dom4_5, 1 hit
PF01301 Glyco_hydro_35, 1 hit
PIRSFiPIRSF006336 B-gal, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SUPFAMiSSF49785 SSF49785, 2 hits
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS01182 GLYCOSYL_HYDROL_F35, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58D55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVVRLLAL LLVPLLLGSA RGLHNATQRT FQIDYRRNRF LKDGQPFRYI
60 70 80 90 100
SGSIHYFRVP RFYWKDRLLK MKMAGLNAIQ TYVAWNFHEL QPGRYNFSGD
110 120 130 140 150
HDVEHFIQLA HELGLLVILR PGPYICAEWD MGGLPAWLLE KKSIVLRSSD
160 170 180 190 200
PDYLAAVDKW LGVLLPKMRP LLYKNGGPII TVQVENEYGS YLSCDYDYLR
210 220 230 240 250
FLQKRFHDHL GEDVLLFTTD GVNERLLQCG ALQGLYATVD FSPGTNLTAA
260 270 280 290 300
FMLQRKFEPT GPLVNSEFYT GWLDHWGQRH STVSSKAVAF TLHDMLALGA
310 320 330 340 350
NVNMYMFIGG TNFAYWNGAN IPYQPQPTSY DYDAPLSEAG DLTEKYFALR
360 370 380 390 400
DIIQKFAKVP EGPIPPSTPK FAYGKVALNK LKTVEDALNI LCPSGPIKSV
410 420 430 440 450
YPLTFIDVKQ YFGFVLYRTM LPEDCSDPTP LSSPLSGVHD RAYVSVNGVA
460 470 480 490 500
QGILERESVI TLNITGKAGA TLDLLVENMG RVNYGSSIND FKGLVSNLTL
510 520 530 540 550
GSKILTNWEI FPLDMEDAVR SHLGTWGGRD RGYHNKARAH SPPTYALPTF
560 570 580 590 600
YVGNFTIPSG IADLPQDTFI QFPGWTKGQV WINGFNLGRY WPVRGPQMTL
610 620 630 640 650
FVPQHILVTS TPNTIVVLEL EHAPCQDGGP ELCTVEFVDK PVFRTVQTHR

HAN
Length:653
Mass (Da):73,413
Last modified:April 26, 2005 - v1
Checksum:i37ED2284A4EB4F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB325580 mRNA Translation: BAF64285.1
BT021742 mRNA Translation: AAX46589.1
RefSeqiNP_001030215.1, NM_001035043.1
UniGeneiBt.6127

Genome annotation databases

GeneIDi507188
KEGGibta:507188

Similar proteinsi

Entry informationi

Entry nameiBGAL_BOVIN
AccessioniPrimary (citable) accession number: Q58D55
Secondary accession number(s): A5LIP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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