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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

Gene

MMAB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPBy similarity
Binding sitei208 – 2081ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 6310ATPBy similarity
Nucleotide bindingi184 – 1885ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Methylmalonic aciduria type B homolog
Gene namesi
Name:MMAB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
BLAST
Chaini27 – 241215Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialPRO_0000238932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281PhosphoserineBy similarity
Modified residuei205 – 2051N6-succinyllysineBy similarity
Modified residuei224 – 2241N6-acetyllysine; alternateBy similarity
Modified residuei224 – 2241N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ58D49.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ58D49.
SMRiQ58D49. Positions 52-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG045589.
InParanoidiQ58D49.
KOiK00798.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58D49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWGPGGRL GLRGCLGARK LLCPRFQSRG PQGVEDGDRP QPSSKTPKVP
60 70 80 90 100
KIYTKTGDKG FSSTFTGERR SKDDQVFEAV GTTDELSSAI GFAMELIAEK
110 120 130 140 150
GHPFVEELQK IQCSLQDVGS ALATPRSSAR EAHLKHATFE AGPILELEQW
160 170 180 190 200
IDKYSRQLPP LTAFILPSGG KSSSALHFCR AVCRRAERRV VPLVQTGETD
210 220 230 240
ANVVKFLNRL SDYLFTLARY TAMKEGNPEK IYKKNDLSDR T
Length:241
Mass (Da):26,587
Last modified:April 26, 2005 - v1
Checksum:i7599729A1AFF48A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → S in AAI11195 (Ref. 2) Curated
Sequence conflicti93 – 931A → V in AAI11195 (Ref. 2) Curated
Sequence conflicti102 – 1021H → Q in AAI11195 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021748 mRNA. Translation: AAX46595.1.
BC111194 mRNA. Translation: AAI11195.1.
RefSeqiNP_001073100.1. NM_001079632.1.
UniGeneiBt.8451.

Genome annotation databases

GeneIDi617636.
KEGGibta:617636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021748 mRNA. Translation: AAX46595.1.
BC111194 mRNA. Translation: AAI11195.1.
RefSeqiNP_001073100.1. NM_001079632.1.
UniGeneiBt.8451.

3D structure databases

ProteinModelPortaliQ58D49.
SMRiQ58D49. Positions 52-234.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ58D49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi617636.
KEGGibta:617636.

Organism-specific databases

CTDi326625.

Phylogenomic databases

HOVERGENiHBG045589.
InParanoidiQ58D49.
KOiK00798.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Miscellaneous databases

NextBioi20900769.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiMMAB_BOVIN
AccessioniPrimary (citable) accession number: Q58D49
Secondary accession number(s): Q2NL20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: March 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.