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Q58D49

- MMAB_BOVIN

UniProt

Q58D49 - MMAB_BOVIN

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

Gene

MMAB

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPBy similarity
    Binding sitei208 – 2081ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 6310ATPBy similarity
    Nucleotide bindingi184 – 1885ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Methylmalonic aciduria type B homolog
    Gene namesi
    Name:MMAB
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
    BLAST
    Chaini27 – 241215Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialPRO_0000238932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051N6-succinyllysineBy similarity
    Modified residuei224 – 2241N6-acetyllysine; alternateBy similarity
    Modified residuei224 – 2241N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ58D49.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ58D49.
    SMRiQ58D49. Positions 52-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG045589.
    KOiK00798.

    Family and domain databases

    Gene3Di1.20.1200.10. 1 hit.
    InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view]
    PfamiPF01923. Cob_adeno_trans. 1 hit.
    [Graphical view]
    ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF89028. SSF89028. 1 hit.
    TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58D49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVWGPGGRL GLRGCLGARK LLCPRFQSRG PQGVEDGDRP QPSSKTPKVP    50
    KIYTKTGDKG FSSTFTGERR SKDDQVFEAV GTTDELSSAI GFAMELIAEK 100
    GHPFVEELQK IQCSLQDVGS ALATPRSSAR EAHLKHATFE AGPILELEQW 150
    IDKYSRQLPP LTAFILPSGG KSSSALHFCR AVCRRAERRV VPLVQTGETD 200
    ANVVKFLNRL SDYLFTLARY TAMKEGNPEK IYKKNDLSDR T 241
    Length:241
    Mass (Da):26,587
    Last modified:April 26, 2005 - v1
    Checksum:i7599729A1AFF48A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251R → S in AAI11195. 1 PublicationCurated
    Sequence conflicti93 – 931A → V in AAI11195. 1 PublicationCurated
    Sequence conflicti102 – 1021H → Q in AAI11195. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021748 mRNA. Translation: AAX46595.1.
    BC111194 mRNA. Translation: AAI11195.1.
    RefSeqiNP_001073100.1. NM_001079632.1.
    UniGeneiBt.8451.

    Genome annotation databases

    GeneIDi617636.
    KEGGibta:617636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021748 mRNA. Translation: AAX46595.1 .
    BC111194 mRNA. Translation: AAI11195.1 .
    RefSeqi NP_001073100.1. NM_001079632.1.
    UniGenei Bt.8451.

    3D structure databases

    ProteinModelPortali Q58D49.
    SMRi Q58D49. Positions 52-234.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q58D49.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 617636.
    KEGGi bta:617636.

    Organism-specific databases

    CTDi 326625.

    Phylogenomic databases

    HOVERGENi HBG045589.
    KOi K00798.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .

    Miscellaneous databases

    NextBioi 20900769.

    Family and domain databases

    Gene3Di 1.20.1200.10. 1 hit.
    InterProi IPR016030. AdoCbl_synth_CblAdoTrfase-like.
    IPR029499. PduO-typ.
    [Graphical view ]
    Pfami PF01923. Cob_adeno_trans. 1 hit.
    [Graphical view ]
    ProDomi PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF89028. SSF89028. 1 hit.
    TIGRFAMsi TIGR00636. PduO_Nterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiMMAB_BOVIN
    AccessioniPrimary (citable) accession number: Q58D49
    Secondary accession number(s): Q2NL20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3