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Q58D49 (MMAB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
EC=2.5.1.17
Alternative name(s):
Cob(I)alamin adenosyltransferase
Methylmalonic aciduria type B homolog
Gene names
Name:MMAB
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.

ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.

Subunit structure

Homotrimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion Potential
Chain27 – 241215Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
PRO_0000238932

Regions

Nucleotide binding54 – 6310ATP By similarity
Nucleotide binding184 – 1885ATP By similarity

Sites

Binding site721ATP By similarity
Binding site2081ATP By similarity

Experimental info

Sequence conflict251R → S in AAI11195. Ref.2
Sequence conflict931A → V in AAI11195. Ref.2
Sequence conflict1021H → Q in AAI11195. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q58D49 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 7599729A1AFF48A9

FASTA24126,587
        10         20         30         40         50         60 
MAVWGPGGRL GLRGCLGARK LLCPRFQSRG PQGVEDGDRP QPSSKTPKVP KIYTKTGDKG 

        70         80         90        100        110        120 
FSSTFTGERR SKDDQVFEAV GTTDELSSAI GFAMELIAEK GHPFVEELQK IQCSLQDVGS 

       130        140        150        160        170        180 
ALATPRSSAR EAHLKHATFE AGPILELEQW IDKYSRQLPP LTAFILPSGG KSSSALHFCR 

       190        200        210        220        230        240 
AVCRRAERRV VPLVQTGETD ANVVKFLNRL SDYLFTLARY TAMKEGNPEK IYKKNDLSDR 


T

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT021748 mRNA. Translation: AAX46595.1.
BC111194 mRNA. Translation: AAI11195.1.
IPIIPI00687691.
RefSeqNP_001073100.1. NM_001079632.1.
UniGeneBt.8451.

3D structure databases

ProteinModelPortalQ58D49.
SMRQ58D49. Positions 52-234.
ModBaseSearch...

Proteomic databases

PRIDEQ58D49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID617636.
KEGGbta:617636.

Organism-specific databases

CTD326625.

Phylogenomic databases

HOVERGENHBG045589.
KOK00798.

Enzyme and pathway databases

BioCycCATTLE:617636-MONOMER.
UniPathwayUPA00148; UER00233.

Family and domain databases

Gene3D1.20.1200.10. 1 hit.
InterProIPR016030. AdoCbl_synth_CblAdoTrfase-like.
[Graphical view]
PfamPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF89028. AdoCbl_synth_CblAdoTrfase-like. 1 hit.
TIGRFAMsTIGR00636. PduO_Nterm. 1 hit.
ProtoNetSearch...

Other

NextBio20900769.

Entry information

Entry nameMMAB_BOVIN
AccessionPrimary (citable) accession number: Q58D49
Secondary accession number(s): Q2NL20
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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