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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

Gene

MMAB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (MMAB)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72ATPBy similarity1
Binding sitei208ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 63ATPBy similarity10
Nucleotide bindingi184 – 188ATPBy similarity5

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Methylmalonic aciduria type B homolog
Gene namesi
Name:MMAB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000023893227 – 241Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineBy similarity1
Modified residuei205N6-succinyllysineBy similarity1
Modified residuei224N6-acetyllysine; alternateBy similarity1
Modified residuei224N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ58D49.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ58D49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG045589.
InParanoidiQ58D49.
KOiK00798.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58D49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWGPGGRL GLRGCLGARK LLCPRFQSRG PQGVEDGDRP QPSSKTPKVP
60 70 80 90 100
KIYTKTGDKG FSSTFTGERR SKDDQVFEAV GTTDELSSAI GFAMELIAEK
110 120 130 140 150
GHPFVEELQK IQCSLQDVGS ALATPRSSAR EAHLKHATFE AGPILELEQW
160 170 180 190 200
IDKYSRQLPP LTAFILPSGG KSSSALHFCR AVCRRAERRV VPLVQTGETD
210 220 230 240
ANVVKFLNRL SDYLFTLARY TAMKEGNPEK IYKKNDLSDR T
Length:241
Mass (Da):26,587
Last modified:April 26, 2005 - v1
Checksum:i7599729A1AFF48A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → S in AAI11195 (Ref. 2) Curated1
Sequence conflicti93A → V in AAI11195 (Ref. 2) Curated1
Sequence conflicti102H → Q in AAI11195 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021748 mRNA. Translation: AAX46595.1.
BC111194 mRNA. Translation: AAI11195.1.
RefSeqiNP_001073100.1. NM_001079632.1.
UniGeneiBt.8451.

Genome annotation databases

GeneIDi617636.
KEGGibta:617636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021748 mRNA. Translation: AAX46595.1.
BC111194 mRNA. Translation: AAI11195.1.
RefSeqiNP_001073100.1. NM_001079632.1.
UniGeneiBt.8451.

3D structure databases

ProteinModelPortaliQ58D49.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ58D49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi617636.
KEGGibta:617636.

Organism-specific databases

CTDi326625.

Phylogenomic databases

HOVERGENiHBG045589.
InParanoidiQ58D49.
KOiK00798.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00233.

Family and domain databases

Gene3Di1.20.1200.10. 1 hit.
InterProiIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamiPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomiPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89028. SSF89028. 1 hit.
TIGRFAMsiTIGR00636. PduO_Nterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMMAB_BOVIN
AccessioniPrimary (citable) accession number: Q58D49
Secondary accession number(s): Q2NL20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.