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Protein

Sorbitol dehydrogenase

Gene

SORD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc; catalyticBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi69Zinc; catalyticBy similarity1
Metal bindingi70Zinc; catalyticBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei298SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1

GO - Molecular functioni

  • identical protein binding Source: Ensembl
  • L-iditol 2-dehydrogenase activity Source: AgBase
  • NAD binding Source: Ensembl
  • zinc ion binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5652227 Fructose biosynthesis
R-BTA-5661270 Catabolism of glucuronate to xylulose-5-phosphate
SABIO-RKiQ58D31

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:SORD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:35131 SORD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002396521 – 356Sorbitol dehydrogenaseAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphoserineBy similarity1
Modified residuei224PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ58D31
PeptideAtlasiQ58D31
PRIDEiQ58D31

Expressioni

Gene expression databases

BgeeiENSBTAG00000025496

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035716

Structurei

3D structure databases

ProteinModelPortaliQ58D31
SMRiQ58D31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0024 Eukaryota
COG1063 LUCA
GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
HOVERGENiHBG005484
InParanoidiQ58D31
KOiK00008
OMAiGVFHNTP
OrthoDBiEOG091G0AQY
TreeFamiTF313060

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q58D31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNEVLLKMHS VGICGSDVHY
60 70 80 90 100
WQHGRIGDFV VKKPMVLGHE ASGTVVKVGS LVRHLQPGDR VAIEPGAPRE
110 120 130 140 150
TDEFCKIGRY NLSPTIFFCA TPPDDGNLCR FYKHNANFCY KLPDNVTFEE
160 170 180 190 200
GALIEPLSVG IHACRRAGVT LGNKVLVCGA GPIGLVSLLA AKAMGAAQVV
210 220 230 240 250
VTDLSASRLS KAKEVGADFI LQISNESPQE IAKKVEGLLG SKPEVTIECT
260 270 280 290 300
GVETSIQAGI YATHSGGTLV LVGLGSEMTS VPLVHAATRE VDIKGVFRYC
310 320 330 340 350
NTWPMAISML ASKSVNVKPL VTHRFPLEKA LEAFETSKKG LGLKVMIKCD

PNDQNP
Length:356
Mass (Da):38,099
Last modified:January 23, 2007 - v3
Checksum:iF7E3ACD6712E71B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021766 mRNA Translation: AAX46613.1
BC122783 mRNA Translation: AAI22784.2
RefSeqiNP_001032397.1, NM_001037320.1
UniGeneiBt.16122

Genome annotation databases

EnsembliENSBTAT00000035849; ENSBTAP00000035716; ENSBTAG00000025496
GeneIDi508954
KEGGibta:508954

Similar proteinsi

Entry informationi

Entry nameiDHSO_BOVIN
AccessioniPrimary (citable) accession number: Q58D31
Secondary accession number(s): Q0II66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health