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Q58D31 (DHSO_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sorbitol dehydrogenase
EC=1.1.1.14
Alternative name(s):
L-iditol 2-dehydrogenase
Gene names
Name:SORD
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm By similarity.

Catalytic activity

L-iditol + NAD+ = L-sorbose + NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion membrane; Peripheral membrane protein. Cell projection › cilium › flagellum. Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 356355Sorbitol dehydrogenase
PRO_0000239652

Sites

Metal binding441Zinc; catalytic By similarity
Metal binding691Zinc; catalytic By similarity
Metal binding701Zinc; catalytic By similarity
Binding site501Substrate By similarity
Binding site1551Substrate By similarity
Binding site2981Substrate By similarity
Binding site2991Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58D31 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F7E3ACD6712E71B1

FASTA35638,099
        10         20         30         40         50         60 
MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNEVLLKMHS VGICGSDVHY WQHGRIGDFV 

        70         80         90        100        110        120 
VKKPMVLGHE ASGTVVKVGS LVRHLQPGDR VAIEPGAPRE TDEFCKIGRY NLSPTIFFCA 

       130        140        150        160        170        180 
TPPDDGNLCR FYKHNANFCY KLPDNVTFEE GALIEPLSVG IHACRRAGVT LGNKVLVCGA 

       190        200        210        220        230        240 
GPIGLVSLLA AKAMGAAQVV VTDLSASRLS KAKEVGADFI LQISNESPQE IAKKVEGLLG 

       250        260        270        280        290        300 
SKPEVTIECT GVETSIQAGI YATHSGGTLV LVGLGSEMTS VPLVHAATRE VDIKGVFRYC 

       310        320        330        340        350 
NTWPMAISML ASKSVNVKPL VTHRFPLEKA LEAFETSKKG LGLKVMIKCD PNDQNP

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT021766 mRNA. Translation: AAX46613.1.
BC122783 mRNA. Translation: AAI22784.2.
IPIIPI00696041.
RefSeqNP_001032397.1. NM_001037320.1.
UniGeneBt.16122.

3D structure databases

ProteinModelPortalQ58D31.
SMRQ58D31. Positions 2-356.
ModBaseSearch...

Proteomic databases

PaxDbQ58D31.
PRIDEQ58D31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000035849; ENSBTAP00000035716; ENSBTAG00000025496.
GeneID508954.
KEGGbta:508954.

Organism-specific databases

CTD6652.

Phylogenomic databases

eggNOGCOG1063.
GeneTreeENSGT00550000074781.
HOGENOMHOG000294670.
HOVERGENHBG005484.
InParanoidQ58D31.
KOK00008.
OMAGNLCRYY.
OrthoDBEOG4WSW9S.

Enzyme and pathway databases

BioCycCATTLE:508954-MONOMER.
SABIO-RKQ58D31.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868757.

Entry information

Entry nameDHSO_BOVIN
AccessionPrimary (citable) accession number: Q58D31
Secondary accession number(s): Q0II66
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: May 29, 2013
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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