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Protein

Sorbitol dehydrogenase

Gene

SORD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Zinc; catalyticBy similarity
Binding sitei50 – 501SubstrateBy similarity
Metal bindingi69 – 691Zinc; catalyticBy similarity
Metal bindingi70 – 701Zinc; catalyticBy similarity
Binding sitei155 – 1551SubstrateBy similarity
Binding sitei298 – 2981SubstrateBy similarity
Binding sitei299 – 2991SubstrateBy similarity

GO - Molecular functioni

  • D-xylulose reductase activity Source: Ensembl
  • L-iditol 2-dehydrogenase activity Source: AgBase
  • NAD binding Source: Ensembl
  • zinc ion binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5652227. Fructose biosynthesis.
R-BTA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.
SABIO-RKQ58D31.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:SORD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

  • Mitochondrion membrane By similarity; Peripheral membrane protein By similarity
  • Cell projectionciliumflagellum By similarity

  • Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Sorbitol dehydrogenasePRO_0000239652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei224 – 2241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ58D31.
PeptideAtlasiQ58D31.
PRIDEiQ58D31.

Expressioni

Gene expression databases

BgeeiENSBTAG00000025496.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035716.

Structurei

3D structure databases

ProteinModelPortaliQ58D31.
SMRiQ58D31. Positions 2-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0024. Eukaryota.
COG1063. LUCA.
GeneTreeiENSGT00550000074781.
HOGENOMiHOG000294670.
HOVERGENiHBG005484.
InParanoidiQ58D31.
KOiK00008.
OMAiMDEFCKI.
OrthoDBiEOG091G0AQY.
TreeFamiTF313060.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58D31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNEVLLKMHS VGICGSDVHY
60 70 80 90 100
WQHGRIGDFV VKKPMVLGHE ASGTVVKVGS LVRHLQPGDR VAIEPGAPRE
110 120 130 140 150
TDEFCKIGRY NLSPTIFFCA TPPDDGNLCR FYKHNANFCY KLPDNVTFEE
160 170 180 190 200
GALIEPLSVG IHACRRAGVT LGNKVLVCGA GPIGLVSLLA AKAMGAAQVV
210 220 230 240 250
VTDLSASRLS KAKEVGADFI LQISNESPQE IAKKVEGLLG SKPEVTIECT
260 270 280 290 300
GVETSIQAGI YATHSGGTLV LVGLGSEMTS VPLVHAATRE VDIKGVFRYC
310 320 330 340 350
NTWPMAISML ASKSVNVKPL VTHRFPLEKA LEAFETSKKG LGLKVMIKCD

PNDQNP
Length:356
Mass (Da):38,099
Last modified:January 23, 2007 - v3
Checksum:iF7E3ACD6712E71B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021766 mRNA. Translation: AAX46613.1.
BC122783 mRNA. Translation: AAI22784.2.
RefSeqiNP_001032397.1. NM_001037320.1.
UniGeneiBt.16122.

Genome annotation databases

EnsembliENSBTAT00000035849; ENSBTAP00000035716; ENSBTAG00000025496.
GeneIDi508954.
KEGGibta:508954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021766 mRNA. Translation: AAX46613.1.
BC122783 mRNA. Translation: AAI22784.2.
RefSeqiNP_001032397.1. NM_001037320.1.
UniGeneiBt.16122.

3D structure databases

ProteinModelPortaliQ58D31.
SMRiQ58D31. Positions 2-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035716.

Proteomic databases

PaxDbiQ58D31.
PeptideAtlasiQ58D31.
PRIDEiQ58D31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000035849; ENSBTAP00000035716; ENSBTAG00000025496.
GeneIDi508954.
KEGGibta:508954.

Organism-specific databases

CTDi6652.

Phylogenomic databases

eggNOGiKOG0024. Eukaryota.
COG1063. LUCA.
GeneTreeiENSGT00550000074781.
HOGENOMiHOG000294670.
HOVERGENiHBG005484.
InParanoidiQ58D31.
KOiK00008.
OMAiMDEFCKI.
OrthoDBiEOG091G0AQY.
TreeFamiTF313060.

Enzyme and pathway databases

ReactomeiR-BTA-5652227. Fructose biosynthesis.
R-BTA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.
SABIO-RKQ58D31.

Gene expression databases

BgeeiENSBTAG00000025496.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHSO_BOVIN
AccessioniPrimary (citable) accession number: Q58D31
Secondary accession number(s): Q0II66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.