Reviewed, UniProtKB/Swiss-Prot Q58D31 (DHSO_BOVIN)

Names and origin

Protein names

Recommended name:
    Sorbitol dehydrogenase
    EC=1.1.1.14
Alternative name(s):
    L-iditol 2-dehydrogenase

Gene names

Name:

SORD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-iditol + NAD(+) = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 356	355	Sorbitol dehydrogenase		PRO_0000239652
Sites
	Metal binding	44	1	Zinc; catalytic By similarity
	Metal binding	69	1	Zinc; catalytic By similarity
	Metal binding	70	1	Zinc; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58D31-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F7E3ACD6712E71B1	FASTA	356	38,099
	10 20 30 40 50 60 MAAAKPENLS LVVHGPGDLR LENYPIPEPG PNEVLLKMHS VGICGSDVHY WQHGRIGDFV 70 80 90 100 110 120 VKKPMVLGHE ASGTVVKVGS LVRHLQPGDR VAIEPGAPRE TDEFCKIGRY NLSPTIFFCA 130 140 150 160 170 180 TPPDDGNLCR FYKHNANFCY KLPDNVTFEE GALIEPLSVG IHACRRAGVT LGNKVLVCGA 190 200 210 220 230 240 GPIGLVSLLA AKAMGAAQVV VTDLSASRLS KAKEVGADFI LQISNESPQE IAKKVEGLLG 250 260 270 280 290 300 SKPEVTIECT GVETSIQAGI YATHSGGTLV LVGLGSEMTS VPLVHAATRE VDIKGVFRYC 310 320 330 340 350 NTWPMAISML ASKSVNVKPL VTHRFPLEKA LEAFETSKKG LGLKVMIKCD PNDQNP

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT021766 mRNA. Translation: AAX46613.1. BC122783 mRNA. Translation: AAI22784.2.
RefSeq	NP_001032397.1.
UniGene	Bt.16122
3D structure databases
SMR	Q58D31. Positions 1-355, 2-356.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000025496. Bos taurus. [Contig view]
GeneID	508954.
KEGG	bta:508954.
Phylogenomic databases
HOVERGEN	Q58D31.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSO_BOVIN

Accession

Primary (citable) accession number: Q58D31
Secondary accession number(s): Q0II66

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 30 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)