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Protein

Tripartite motif-containing protein 54

Gene

TRIM54

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May bind and stabilize microtubules during myotubes formation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Gene namesi
Name:TRIM54
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Tripartite motif-containing protein 54PRO_0000056281Add
BLAST

Proteomic databases

PaxDbiQ58D15.
PRIDEiQ58D15.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55. Interacts with tubulin (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024312.

Structurei

3D structure databases

ProteinModelPortaliQ58D15.
SMRiQ58D15. Positions 118-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 32959COSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 21144Mediates microtubule-binding and homooligomerizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili185 – 25874Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 8257RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri121 – 16343B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDQF. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ58D15.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58D15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRSSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEENSRRQK QLLNQRFEGL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GTMSKVELAG
310 320 330 340 350
RPEPGYERMD QFTVSVEHVA EMLRTIDFQP GTSGEEEDEE VAVEGEEGNA
360
GPEEERTDGR ESTGQH
Length:366
Mass (Da):41,337
Last modified:April 26, 2005 - v1
Checksum:i9058297044439497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021782 mRNA. Translation: AAX46629.1.
BC114171 mRNA. Translation: AAI14172.1.
RefSeqiNP_001017951.1. NM_001017951.1.
UniGeneiBt.9981.

Genome annotation databases

EnsembliENSBTAT00000024312; ENSBTAP00000024312; ENSBTAG00000018267.
GeneIDi535320.
KEGGibta:535320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021782 mRNA. Translation: AAX46629.1.
BC114171 mRNA. Translation: AAI14172.1.
RefSeqiNP_001017951.1. NM_001017951.1.
UniGeneiBt.9981.

3D structure databases

ProteinModelPortaliQ58D15.
SMRiQ58D15. Positions 118-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024312.

Proteomic databases

PaxDbiQ58D15.
PRIDEiQ58D15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024312; ENSBTAP00000024312; ENSBTAG00000018267.
GeneIDi535320.
KEGGibta:535320.

Organism-specific databases

CTDi57159.

Phylogenomic databases

eggNOGiENOG410KDQF. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ58D15.
KOiK10653.
OMAiGYESMDQ.
OrthoDBiEOG7VDXPK.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiTRI54_BOVIN
AccessioniPrimary (citable) accession number: Q58D15
Secondary accession number(s): Q29RH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.