ID   P5CR3_BOVIN             Reviewed;         308 AA.
AC   Q58D08;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Pyrroline-5-carboxylate reductase 3;
DE            Short=P5C reductase 3;
DE            Short=P5CR 3;
DE            EC=1.5.1.2;
DE   AltName: Full=Pyrroline-5-carboxylate reductase-like protein;
GN   Name=PYCRL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; BT021789; AAX46636.1; -; mRNA.
DR   EMBL; BC149378; AAI49379.1; -; mRNA.
DR   IPI; IPI00686752; -.
DR   RefSeq; NP_001014906.1; -.
DR   UniGene; Bt.5422; -.
DR   Ensembl; ENSBTAG00000016810; Bos taurus.
DR   GeneID; 512526; -.
DR   KEGG; bta:512526; -.
DR   HOVERGEN; Q58D08; -.
DR   OMA; Q58D08; RVSPNLP.
DR   BRENDA; 1.5.1.2; 251.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    308       Pyrroline-5-carboxylate reductase 3.
FT                                /FTId=PRO_0000324560.
SQ   SEQUENCE   308 AA;  32035 MW;  08BD9AD07E567D3D CRC64;
     MAAAAEESGW RRVGFVGAGR MAEAIAQGLI QAGKVEAEHV LASAPSDRNL CRFRAMGCQT
     THSNLEVLHS CSLVFFATKP HILPAVLVEV APAVTAEHIL VSVAAGVSLS TLEKLLPPMA
     RVLRVSPNLP CIVQEGAMVM ARGCCAGSYE AQLLRSLLEA CGQCEEVPEA QVDVHTGLSG
     SGVAFVCAFS EALAEGAIKM GMPSGLAHRI AAQTLLGTAK VLLQKGQHPA QLRTDVCTPG
     GTTIYGLHVL EQGGLRATAM SAVEAATCRA RELSRNPSPV VAQVPSVLQA LQGEGALAHR
     EHSSVARS
//