Reviewed, UniProtKB/Swiss-Prot Q58D08 (P5CR3_BOVIN)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2
Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein

Gene names

Name:

PYCRL

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Pyrroline-5-carboxylate reductase 3		PRO_0000324560

Sequences

	Sequence		Length	Mass (Da)
	Q58D08-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 08BD9AD07E567D3D	FASTA	308	32,035
	10 20 30 40 50 60 MAAAAEESGW RRVGFVGAGR MAEAIAQGLI QAGKVEAEHV LASAPSDRNL CRFRAMGCQT 70 80 90 100 110 120 THSNLEVLHS CSLVFFATKP HILPAVLVEV APAVTAEHIL VSVAAGVSLS TLEKLLPPMA 130 140 150 160 170 180 RVLRVSPNLP CIVQEGAMVM ARGCCAGSYE AQLLRSLLEA CGQCEEVPEA QVDVHTGLSG 190 200 210 220 230 240 SGVAFVCAFS EALAEGAIKM GMPSGLAHRI AAQTLLGTAK VLLQKGQHPA QLRTDVCTPG 250 260 270 280 290 300 GTTIYGLHVL EQGGLRATAM SAVEAATCRA RELSRNPSPV VAQVPSVLQA LQGEGALAHR EHSSVARS

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT021789 mRNA. Translation: AAX46636.1. BC149378 mRNA. Translation: AAI49379.1.
RefSeq	NP_001014906.1.
UniGene	Bt.5422
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000016810. Bos taurus. [Contig view]
GeneID	512526.
KEGG	bta:512526.
Phylogenomic databases
HOVERGEN	Q58D08.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR3_BOVIN

Accession

Primary (citable) accession number: Q58D08

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)