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Protein

Neuromedin-U receptor 2

Gene

NMUR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Gene namesi
Name:NMUR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 7911CytoplasmicSequence analysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 12020ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 13919Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16223CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 21128ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 26230CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 29815ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 40788CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Neuromedin-U receptor 2PRO_0000069909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 201PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ58CW4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014782.

Structurei

3D structure databases

ProteinModelPortaliQ58CW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ58CW4.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG7GXPBG.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58CW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKHENVSWM YQQELKDPFK KYLNNTDDYL ALLCGPRRSH LFLPVTAVYA
60 70 80 90 100
LIFVVGVVGN LLVCLVILRH QTMKTPTNYY LFSLAVSDLL VLLLGMPLEV
110 120 130 140 150
YEMWRNYPFL FGPVGCYFKT ALFETVCFAS ILSVTTVSVE RYVAVLHPFR
160 170 180 190 200
AKLKSTRGRA LRILGIVWGL SVLFSLPNTS IHGIKLHYFP NGSIIPGSAT
210 220 230 240 250
CTVIKPMWIY NFIIQVTSLL FYILPMTVIS VLYYLMGLKL KKDQHLEADK
260 270 280 290 300
VTANIQRPSR KSVTKMLFVL VLVFAICWAP FHIDRLFFSF VEEWTEPLAA
310 320 330 340 350
VFNLIHVVSG VFFYLSSAVN PIIYNLLSHR FQAAFRTVIP PSCQQQHSHN
360 370 380 390 400
HSPGPSMQRN IFLTECHLVE LTEDVAPQFP RQLSVLSSQL PTALCTGQVP

RKELAKS
Length:407
Mass (Da):46,343
Last modified:April 26, 2005 - v1
Checksum:i6C49046C250DBC22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021833 mRNA. Translation: AAX46680.1.
RefSeqiNP_001030220.1. NM_001035048.1.
UniGeneiBt.37376.

Genome annotation databases

EnsembliENSBTAT00000014782; ENSBTAP00000014782; ENSBTAG00000011131.
GeneIDi507439.
KEGGibta:507439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021833 mRNA. Translation: AAX46680.1.
RefSeqiNP_001030220.1. NM_001035048.1.
UniGeneiBt.37376.

3D structure databases

ProteinModelPortaliQ58CW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014782.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ58CW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014782; ENSBTAP00000014782; ENSBTAG00000011131.
GeneIDi507439.
KEGGibta:507439.

Organism-specific databases

CTDi56923.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ58CW4.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG7GXPBG.
TreeFamiTF318522.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20868059.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNMUR2_BOVIN
AccessioniPrimary (citable) accession number: Q58CW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.