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Protein

Diphosphoinositol polyphosphate phosphohydrolase 3-beta

Gene

NUDT11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.By similarity

Catalytic activityi

Diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.By similarity
P1,P(6)-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-pentaphosphate + AMP.By similarity
P1,P(5)-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 3 Mg2+ or Mn2+ ions per subunit. Mn2+ may be the true cofactor in vivo.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91SubstrateBy similarity
Binding sitei40 – 401SubstrateBy similarity
Metal bindingi49 – 491Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi65 – 651Magnesium 2By similarity
Metal bindingi65 – 651Magnesium 3By similarity
Active sitei68 – 681Proton acceptorBy similarity
Metal bindingi69 – 691Magnesium 1By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diphosphoinositol polyphosphate phosphohydrolase 3-beta (EC:3.6.1.52By similarity)
Short name:
DIPP-3-beta
Short name:
DIPP3-beta
Alternative name(s):
Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
Diadenosine hexaphosphate hydrolase (AMP-forming) (EC:3.6.1.60By similarity)
Nucleoside diphosphate-linked moiety X motif 11
Short name:
Nudix motif 11
Gene namesi
Name:NUDT11
Synonyms:DIPP3B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Diphosphoinositol polyphosphate phosphohydrolase 3-betaPRO_0000057064Add
BLAST

Proteomic databases

PaxDbiQ58CW0.
PRIDEiQ58CW0.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049572.

Structurei

3D structure databases

ProteinModelPortaliQ58CW0.
SMRiQ58CW0. Positions 8-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 144128Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 193Substrate bindingBy similarity
Regioni89 – 913Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 7122Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. DIPP subfamily.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
HOGENOMiHOG000237336.
HOVERGENiHBG053341.
InParanoidiQ58CW0.
KOiK07766.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58CW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCKPNQTRT YDPEGFKKRA ACLCFRSERE DEVLLVSSSR YPDRWIVPGG
60 70 80 90 100
GMEPEEEPGG AAVREVFEEA GVKGKLGRLL GNFEQNQDRK HRTYVYVLTV
110 120 130 140 150
TEILEDWEDS VSIGRKREWF KVEDAIKVLQ CHKPVHAEYL QKLKLGGSPT
160
NGNSVAPSPP EGDP
Length:164
Mass (Da):18,519
Last modified:July 5, 2005 - v2
Checksum:i335256116E97AE72
GO

Sequence cautioni

The sequence AAX46684 differs from that shown. Reason: Frameshift at position 160. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021837 mRNA. Translation: AAX46684.1. Frameshift.
RefSeqiNP_001030565.2. NM_001035488.2.
UniGeneiBt.24396.
Bt.88839.

Genome annotation databases

GeneIDi616931.
KEGGibta:616931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021837 mRNA. Translation: AAX46684.1. Frameshift.
RefSeqiNP_001030565.2. NM_001035488.2.
UniGeneiBt.24396.
Bt.88839.

3D structure databases

ProteinModelPortaliQ58CW0.
SMRiQ58CW0. Positions 8-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049572.

Proteomic databases

PaxDbiQ58CW0.
PRIDEiQ58CW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi616931.
KEGGibta:616931.

Organism-specific databases

CTDi170685.

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
HOGENOMiHOG000237336.
HOVERGENiHBG053341.
InParanoidiQ58CW0.
KOiK07766.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUD11_BOVIN
AccessioniPrimary (citable) accession number: Q58CW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.