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Protein

Palmitoyltransferase ZDHHC16

Gene

ZDHHC16

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processApoptosis, DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC16By similarity (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 16By similarity
Short name:
DHHC-16By similarity
Gene namesi
Name:ZDHHC16By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 116LumenalSequence analysisAdd BLAST16
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 198CytoplasmicSequence analysisAdd BLAST61
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 266LumenalSequence analysisAdd BLAST47
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 377CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128961 – 377Palmitoyltransferase ZDHHC16Add BLAST377

Proteomic databases

PaxDbiQ58CU4.
PRIDEiQ58CU4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012702.

Interactioni

Subunit structurei

Interacts with ABL1 (By similarity). Interacts with COPS5/JAB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016882.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 205DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1313. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00900000140969.
HOGENOMiHOG000234766.
HOVERGENiHBG054667.
InParanoidiQ58CU4.
KOiK18932.
OMAiKNWKLFL.
OrthoDBiEOG091G0FLT.
TreeFamiTF320809.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58CU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGQWSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPIYW LVDNVIRWCG VVFVVLVIVL TSSIVAIAYL
110 120 130 140 150
CVLPLILQTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
MTTVSICKKC INPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ
260 270 280 290 300
TPPPTFSFRE RVTHKSLVYL WFLCSSVALA LGALTIWHAV LISRGETSIE
310 320 330 340 350
RHINKKERQR LQAKGRVFRN HYNYGCLDNW KVFLGVDTGR HWLTRVLLPS
360 370
SHLPHGNGMS WDPPPWVTAH SASVMAV
Length:377
Mass (Da):43,614
Last modified:April 26, 2005 - v1
Checksum:iEC2FFA5D683A45E5
GO
Isoform 2 (identifier: Q58CU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.

Show »
Length:361
Mass (Da):41,775
Checksum:i1169E0FF33EA83CD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016273231 – 246Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021708 mRNA. Translation: AAX46555.1.
BT021853 mRNA. Translation: AAX46700.1.
BC113326 mRNA. Translation: AAI13327.1.
RefSeqiNP_001019653.1. NM_001024482.2. [Q58CU4-1]
XP_005225537.1. XM_005225480.2. [Q58CU4-1]
XP_005225538.1. XM_005225481.2. [Q58CU4-1]
XP_005225539.1. XM_005225482.2. [Q58CU4-1]
XP_005225541.1. XM_005225484.2. [Q58CU4-2]
XP_010818143.1. XM_010819841.2. [Q58CU4-1]
UniGeneiBt.106644.

Genome annotation databases

EnsembliENSBTAT00000016882; ENSBTAP00000016882; ENSBTAG00000012702. [Q58CU4-1]
ENSBTAT00000016883; ENSBTAP00000016883; ENSBTAG00000012702. [Q58CU4-2]
GeneIDi506085.
KEGGibta:506085.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZDH16_BOVIN
AccessioniPrimary (citable) accession number: Q58CU4
Secondary accession number(s): Q2HJ39, Q58D89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: December 20, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families