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Protein

Eukaryotic translation initiation factor 2D

Gene

EIF2D

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2D
Short name:
eIF2d
Alternative name(s):
Ligatin
Gene namesi
Name:EIF2D
Synonyms:LGTN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Eukaryotic translation initiation factor 2DPRO_0000130610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei232 – 2321PhosphoserineBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ58CR3.
PRIDEiQ58CR3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010432.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013769.

Structurei

3D structure databases

ProteinModelPortaliQ58CR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 17381PUAPROSITE-ProRule annotationAdd
BLAST
Domaini486 – 55974SUI1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF2D family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2522. Eukaryota.
ENOG410XSAV. LUCA.
HOVERGENiHBG006268.
InParanoidiQ58CR3.
KOiK15027.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.30.780.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR001950. SUI1.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
SSF55159. SSF55159. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
PS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58CR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKAFRVKS NTAIKGSDRR KLRADVAAVF PTLGTDQVSE LVPGKEELNI
60 70 80 90 100
VKLYAHRGDA VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP
110 120 130 140 150
LVLEKLVGGA DLMLPGLVVP PAGLPQVQKG DLCAVALVGN RAPVAVGVAA
160 170 180 190 200
MSTAEMLASG LKGRGFCVLH SYQDHLWRSG DKSSPPSIAP LALNPPDLSE
210 220 230 240 250
GKGCVKADTA LQGAMRQLTL EEEVQQRCEE KSPSEATEDP GPGGLHVDPM
260 270 280 290 300
DSKTLQEQMD ELLQTCFLHA LKCSVRKADL PLLTSTLLGS HMFSCCPEGR
310 320 330 340 350
QLDIKKSSYK KLSKFLQHMQ QEQIIQVQEL SKGVESIVAV DWKHPRITSF
360 370 380 390 400
VIPEPSPTSQ TIQEGSREQP YHPPDIKPLY CVPASMTLLF QESGHKKGSV
410 420 430 440 450
LEGSEVRTFV INYAKKNDLV DADNKNLVKL DPILCDCILE KDEQHTVTKL
460 470 480 490 500
PWDSLLGRCL EKLQPAYQVT FPGQEPIVKK GRICPIDITL AQKASNKKVT
510 520 530 540 550
VVRNLEAYGL DPRSVAATLQ QRCQASTTVT SAPGLKDSVQ VQIQGNQIHH
560 570
LGRLLLEEYR LPRKHIQGLE KAPKPGKKK
Length:579
Mass (Da):63,647
Last modified:April 26, 2005 - v1
Checksum:i92215E1B03493AE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021884 mRNA. Translation: AAX46731.1.
BC114158 mRNA. Translation: AAI14159.1.
RefSeqiNP_001030276.1. NM_001035104.1.
UniGeneiBt.59019.

Genome annotation databases

GeneIDi511844.
KEGGibta:511844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021884 mRNA. Translation: AAX46731.1.
BC114158 mRNA. Translation: AAI14159.1.
RefSeqiNP_001030276.1. NM_001035104.1.
UniGeneiBt.59019.

3D structure databases

ProteinModelPortaliQ58CR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013769.

Proteomic databases

PaxDbiQ58CR3.
PRIDEiQ58CR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi511844.
KEGGibta:511844.

Organism-specific databases

CTDi1939.

Phylogenomic databases

eggNOGiKOG2522. Eukaryota.
ENOG410XSAV. LUCA.
HOVERGENiHBG006268.
InParanoidiQ58CR3.
KOiK15027.

Gene expression databases

BgeeiENSBTAG00000010432.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.30.780.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR001950. SUI1.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
SSF55159. SSF55159. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
PS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF2D_BOVIN
AccessioniPrimary (citable) accession number: Q58CR3
Secondary accession number(s): Q29RI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.