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Q58CQ9

- VNN1_BOVIN

UniProt

Q58CQ9 - VNN1_BOVIN

Protein

Pantetheinase

Gene

VNN1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.By similarity

    Catalytic activityi

    (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801Proton acceptorPROSITE-ProRule annotation
    Active sitei179 – 1791Proton donorPROSITE-ProRule annotation
    Active sitei212 – 2121NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. pantetheine hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. chronic inflammatory response Source: Ensembl
    3. innate immune response Source: Ensembl
    4. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    5. pantothenate metabolic process Source: Ensembl
    6. positive regulation of T cell differentiation in thymus Source: Ensembl
    7. single organismal cell-cell adhesion Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantetheinase (EC:3.5.1.92)
    Alternative name(s):
    Pantetheine hydrolase
    Vascular non-inflammatory molecule 1
    Short name:
    Vanin-1
    Gene namesi
    Name:VNN1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 9

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 492470PantetheinasePRO_0000239702Add
    BLAST
    Propeptidei493 – 51018Removed in mature formSequence AnalysisPRO_0000239703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Lipidationi492 – 4921GPI-anchor amidated aspartateSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ58CQ9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58CQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 336311CN hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0388.
    GeneTreeiENSGT00390000013823.
    HOGENOMiHOG000007627.
    HOVERGENiHBG003996.
    InParanoidiQ58CQ9.
    KOiK08069.
    OrthoDBiEOG7HF1J0.
    TreeFamiTF323645.

    Family and domain databases

    Gene3Di3.60.110.10. 1 hit.
    InterProiIPR012101. Biotinidase_euk.
    IPR003010. C-N_Hydrolase.
    [Graphical view]
    PANTHERiPTHR10609. PTHR10609. 1 hit.
    PfamiPF00795. CN_hydrolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011861. Biotinidase. 1 hit.
    SUPFAMiSSF56317. SSF56317. 1 hit.
    PROSITEiPS50263. CN_HYDROLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58CQ9-1 [UniParc]FASTAAdd to Basket

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    MIMSQLLNYV AVLFFCVSRA SSLDTFIAAV YEHAVILPNA TLVPVSPEEA    50
    LAVMNRNLDL LEGAVTSASK QGAHIIVTPE DGIYGFNFTR ESIYPYLEDI 100
    PDPQVNWIPC NNPDRFGHTP VQQRLSCLAK DNSIYIVANI GDKKSCNASD 150
    PQCPPDGRYQ YNTDVVFDSK GKLVARYHKQ NLFLNEDQFN APKEPEVVTF 200
    NTTFGKFGIF TCFDILFHDP AVTLVRDSHV DTILFPTAWM NVLPHLSAIE 250
    FHSAWAMGMR VNFLASNLHY PLKKMTGSGI YAPDSPRAFH YDMKTEEGKL 300
    LLAQLDSHPH PTPVVNWTSY ASGVEAHSVG NQEFTGIIFF DEFTFLELKE 350
    IGGNYTVCQR DLCCHLSYKM SEKRSDEVYA LGAFDGLHTV EGSYYLQICT 400
    LLKCKTTDLH TCGDSVETAS TRFEMFSLSG TFGTQYVFPE VLLSEIQLAP 450
    GEFQVSNDGR LFSLKPTSGP VLTVTLFGRL YEKDSAPNTL SDLTTQALRL 500
    NPKTDAWKSK 510
    Length:510
    Mass (Da):56,947
    Last modified:April 26, 2005 - v1
    Checksum:iF38CF8E2D14ADD03
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti169 – 1691S → T in AAI49326. 1 PublicationCurated
    Sequence conflicti229 – 2291H → R in AAI49326. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021888 mRNA. Translation: AAX46735.1.
    BC149325 mRNA. Translation: AAI49326.1.
    RefSeqiNP_001019727.2. NM_001024556.2.
    UniGeneiBt.28243.

    Genome annotation databases

    EnsembliENSBTAT00000020086; ENSBTAP00000020086; ENSBTAG00000015094.
    GeneIDi526704.
    KEGGibta:526704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021888 mRNA. Translation: AAX46735.1 .
    BC149325 mRNA. Translation: AAI49326.1 .
    RefSeqi NP_001019727.2. NM_001024556.2.
    UniGenei Bt.28243.

    3D structure databases

    ProteinModelPortali Q58CQ9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q58CQ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000020086 ; ENSBTAP00000020086 ; ENSBTAG00000015094 .
    GeneIDi 526704.
    KEGGi bta:526704.

    Organism-specific databases

    CTDi 8876.

    Phylogenomic databases

    eggNOGi COG0388.
    GeneTreei ENSGT00390000013823.
    HOGENOMi HOG000007627.
    HOVERGENi HBG003996.
    InParanoidi Q58CQ9.
    KOi K08069.
    OrthoDBi EOG7HF1J0.
    TreeFami TF323645.

    Miscellaneous databases

    NextBioi 20874430.

    Family and domain databases

    Gene3Di 3.60.110.10. 1 hit.
    InterProi IPR012101. Biotinidase_euk.
    IPR003010. C-N_Hydrolase.
    [Graphical view ]
    PANTHERi PTHR10609. PTHR10609. 1 hit.
    Pfami PF00795. CN_hydrolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011861. Biotinidase. 1 hit.
    SUPFAMi SSF56317. SSF56317. 1 hit.
    PROSITEi PS50263. CN_HYDROLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal medulla.

    Entry informationi

    Entry nameiVNN1_BOVIN
    AccessioniPrimary (citable) accession number: Q58CQ9
    Secondary accession number(s): A6QPH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3