SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q58CQ9

- VNN1_BOVIN

UniProt

Q58CQ9 - VNN1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pantetheinase
Gene
VNN1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine By similarity.

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptor By similarity
Active sitei179 – 1791Proton donor By similarity
Active sitei212 – 2121Nucleophile By similarity

GO - Molecular functioni

  1. pantetheine hydrolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. chronic inflammatory response Source: Ensembl
  3. innate immune response Source: Ensembl
  4. negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  5. pantothenate metabolic process Source: Ensembl
  6. positive regulation of T cell differentiation in thymus Source: Ensembl
  7. single organismal cell-cell adhesion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.92)
Alternative name(s):
Pantetheine hydrolase
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:VNN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 9

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 492470Pantetheinase
PRO_0000239702Add
BLAST
Propeptidei493 – 51018Removed in mature form Reviewed prediction
PRO_0000239703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction
Lipidationi492 – 4921GPI-anchor amidated aspartate Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ58CQ9.

Structurei

3D structure databases

ProteinModelPortaliQ58CQ9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 336311CN hydrolase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0388.
GeneTreeiENSGT00390000013823.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ58CQ9.
KOiK08069.
OrthoDBiEOG7HF1J0.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58CQ9-1 [UniParc]FASTAAdd to Basket

« Hide

MIMSQLLNYV AVLFFCVSRA SSLDTFIAAV YEHAVILPNA TLVPVSPEEA    50
LAVMNRNLDL LEGAVTSASK QGAHIIVTPE DGIYGFNFTR ESIYPYLEDI 100
PDPQVNWIPC NNPDRFGHTP VQQRLSCLAK DNSIYIVANI GDKKSCNASD 150
PQCPPDGRYQ YNTDVVFDSK GKLVARYHKQ NLFLNEDQFN APKEPEVVTF 200
NTTFGKFGIF TCFDILFHDP AVTLVRDSHV DTILFPTAWM NVLPHLSAIE 250
FHSAWAMGMR VNFLASNLHY PLKKMTGSGI YAPDSPRAFH YDMKTEEGKL 300
LLAQLDSHPH PTPVVNWTSY ASGVEAHSVG NQEFTGIIFF DEFTFLELKE 350
IGGNYTVCQR DLCCHLSYKM SEKRSDEVYA LGAFDGLHTV EGSYYLQICT 400
LLKCKTTDLH TCGDSVETAS TRFEMFSLSG TFGTQYVFPE VLLSEIQLAP 450
GEFQVSNDGR LFSLKPTSGP VLTVTLFGRL YEKDSAPNTL SDLTTQALRL 500
NPKTDAWKSK 510
Length:510
Mass (Da):56,947
Last modified:April 26, 2005 - v1
Checksum:iF38CF8E2D14ADD03
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691S → T in AAI49326. 1 Publication
Sequence conflicti229 – 2291H → R in AAI49326. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021888 mRNA. Translation: AAX46735.1.
BC149325 mRNA. Translation: AAI49326.1.
RefSeqiNP_001019727.2. NM_001024556.2.
UniGeneiBt.28243.

Genome annotation databases

EnsembliENSBTAT00000020086; ENSBTAP00000020086; ENSBTAG00000015094.
GeneIDi526704.
KEGGibta:526704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021888 mRNA. Translation: AAX46735.1 .
BC149325 mRNA. Translation: AAI49326.1 .
RefSeqi NP_001019727.2. NM_001024556.2.
UniGenei Bt.28243.

3D structure databases

ProteinModelPortali Q58CQ9.
ModBasei Search...

Proteomic databases

PRIDEi Q58CQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000020086 ; ENSBTAP00000020086 ; ENSBTAG00000015094 .
GeneIDi 526704.
KEGGi bta:526704.

Organism-specific databases

CTDi 8876.

Phylogenomic databases

eggNOGi COG0388.
GeneTreei ENSGT00390000013823.
HOGENOMi HOG000007627.
HOVERGENi HBG003996.
InParanoidi Q58CQ9.
KOi K08069.
OrthoDBi EOG7HF1J0.
TreeFami TF323645.

Miscellaneous databases

NextBioi 20874430.

Family and domain databases

Gene3Di 3.60.110.10. 1 hit.
InterProi IPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view ]
PANTHERi PTHR10609. PTHR10609. 1 hit.
Pfami PF00795. CN_hydrolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF011861. Biotinidase. 1 hit.
SUPFAMi SSF56317. SSF56317. 1 hit.
PROSITEi PS50263. CN_HYDROLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.

Entry informationi

Entry nameiVNN1_BOVIN
AccessioniPrimary (citable) accession number: Q58CQ9
Secondary accession number(s): A6QPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi