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Q58CQ9 (VNN1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantetheinase

EC=3.5.1.92
Alternative name(s):
Pantetheine hydrolase
Vascular non-inflammatory molecule 1
Short name=Vanin-1
Gene names
Name:VNN1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine By similarity.

Catalytic activity

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Sequence similarities

Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

Contains 1 CN hydrolase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 492470Pantetheinase
PRO_0000239702
Propeptide493 – 51018Removed in mature form Potential
PRO_0000239703

Regions

Domain26 – 336311CN hydrolase

Amino acid modifications

Lipidation4921GPI-anchor amidated aspartate Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1691S → T in AAI49326. Ref.2
Sequence conflict2291H → R in AAI49326. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q58CQ9 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: F38CF8E2D14ADD03

FASTA51056,947
        10         20         30         40         50         60 
MIMSQLLNYV AVLFFCVSRA SSLDTFIAAV YEHAVILPNA TLVPVSPEEA LAVMNRNLDL 

        70         80         90        100        110        120 
LEGAVTSASK QGAHIIVTPE DGIYGFNFTR ESIYPYLEDI PDPQVNWIPC NNPDRFGHTP 

       130        140        150        160        170        180 
VQQRLSCLAK DNSIYIVANI GDKKSCNASD PQCPPDGRYQ YNTDVVFDSK GKLVARYHKQ 

       190        200        210        220        230        240 
NLFLNEDQFN APKEPEVVTF NTTFGKFGIF TCFDILFHDP AVTLVRDSHV DTILFPTAWM 

       250        260        270        280        290        300 
NVLPHLSAIE FHSAWAMGMR VNFLASNLHY PLKKMTGSGI YAPDSPRAFH YDMKTEEGKL 

       310        320        330        340        350        360 
LLAQLDSHPH PTPVVNWTSY ASGVEAHSVG NQEFTGIIFF DEFTFLELKE IGGNYTVCQR 

       370        380        390        400        410        420 
DLCCHLSYKM SEKRSDEVYA LGAFDGLHTV EGSYYLQICT LLKCKTTDLH TCGDSVETAS 

       430        440        450        460        470        480 
TRFEMFSLSG TFGTQYVFPE VLLSEIQLAP GEFQVSNDGR LFSLKPTSGP VLTVTLFGRL 

       490        500        510 
YEKDSAPNTL SDLTTQALRL NPKTDAWKSK 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal medulla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT021888 mRNA. Translation: AAX46735.1.
BC149325 mRNA. Translation: AAI49326.1.
RefSeqNP_001019727.2. NM_001024556.2.
UniGeneBt.28243.

3D structure databases

ProteinModelPortalQ58CQ9.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ58CQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020086; ENSBTAP00000020086; ENSBTAG00000015094.
GeneID526704.
KEGGbta:526704.

Organism-specific databases

CTD8876.

Phylogenomic databases

eggNOGCOG0388.
GeneTreeENSGT00390000013823.
HOGENOMHOG000007627.
HOVERGENHBG003996.
InParanoidQ58CQ9.
KOK08069.
OrthoDBEOG7HF1J0.
TreeFamTF323645.

Family and domain databases

Gene3D3.60.110.10. 1 hit.
InterProIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERPTHR10609. PTHR10609. 1 hit.
PfamPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFPIRSF011861. Biotinidase. 1 hit.
SUPFAMSSF56317. SSF56317. 1 hit.
PROSITEPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874430.

Entry information

Entry nameVNN1_BOVIN
AccessionPrimary (citable) accession number: Q58CQ9
Secondary accession number(s): A6QPH4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families