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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

ARPC1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

  1. actin filament binding Source: GO_Central
  2. structural constituent of cytoskeleton Source: Ensembl

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 25

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. Arp2/3 protein complex Source: GO_Central
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: Ensembl
  4. focal adhesion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 372371Actin-related protein 2/3 complex subunit 1BPRO_0000239701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ58CQ2.
PRIDEiQ58CQ2.

Expressioni

Gene expression databases

ExpressionAtlasiQ58CQ2. baseline and differential.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29791N.

Structurei

Secondary structure

1
372
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Beta strandi14 – 163Combined sources
Beta strandi20 – 256Combined sources
Beta strandi28 – 3811Combined sources
Beta strandi41 – 499Combined sources
Beta strandi55 – 617Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 716Combined sources
Beta strandi72 – 743Combined sources
Beta strandi76 – 827Combined sources
Beta strandi85 – 917Combined sources
Beta strandi99 – 1046Combined sources
Beta strandi108 – 1158Combined sources
Beta strandi118 – 1269Combined sources
Turni127 – 1304Combined sources
Beta strandi131 – 1377Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi154 – 1618Combined sources
Beta strandi166 – 1705Combined sources
Turni174 – 1763Combined sources
Beta strandi194 – 1974Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi205 – 2106Combined sources
Beta strandi212 – 22110Combined sources
Turni222 – 2243Combined sources
Beta strandi225 – 2306Combined sources
Helixi231 – 2333Combined sources
Beta strandi237 – 2415Combined sources
Beta strandi243 – 2453Combined sources
Beta strandi247 – 2548Combined sources
Beta strandi257 – 2626Combined sources
Beta strandi268 – 2736Combined sources
Turni274 – 2774Combined sources
Beta strandi278 – 2814Combined sources
Helixi298 – 3047Combined sources
Beta strandi322 – 3276Combined sources
Beta strandi329 – 3379Combined sources
Turni338 – 3403Combined sources
Beta strandi343 – 3497Combined sources
Beta strandi352 – 3587Combined sources
Helixi359 – 3657Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00C1-372[»]
1TYQX-ray2.55C1-372[»]
1U2VX-ray2.55C1-372[»]
2P9IX-ray2.46C1-372[»]
2P9KX-ray2.59C1-372[»]
2P9LX-ray2.65C1-372[»]
2P9NX-ray2.85C1-372[»]
2P9PX-ray2.90C1-372[»]
2P9SX-ray2.68C1-372[»]
2P9UX-ray2.75C1-372[»]
3DXKX-ray2.70C1-372[»]
3DXMX-ray2.85C1-372[»]
3RSEX-ray2.65C1-372[»]
3UKRX-ray2.48C1-372[»]
3UKUX-ray2.75C1-372[»]
3ULEX-ray2.50C1-372[»]
4JD2X-ray3.08C1-372[»]
ProteinModelPortaliQ58CQ2.
SMRiQ58CQ2. Positions 2-372.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58CQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1Add
BLAST
Repeati50 – 8940WD 2Add
BLAST
Repeati94 – 13542WD 3Add
BLAST
Repeati140 – 17940WD 4Add
BLAST
Repeati242 – 28039WD 5Add
BLAST
Repeati324 – 36744WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ58CQ2.
KOiK05757.
OMAiVLFTYDS.
OrthoDBiEOG77DJ62.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030141. ARC1B.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF10. PTHR10709:SF10. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58CQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE
60 70 80 90 100
HNGQVTGIDW APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNEKK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNSVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVR SLESALKDLK IV
Length:372
Mass (Da):40,976
Last modified:January 23, 2007 - v4
Checksum:iB412F9C50DC93748
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661R → H in AAX46742 (PubMed:16305752).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021526 mRNA. Translation: AAX46373.1.
BT021895 mRNA. Translation: AAX46742.1.
BT026160 mRNA. Translation: ABG66999.1.
BC102942 mRNA. Translation: AAI02943.1.
RefSeqiNP_001014844.1. NM_001014844.3.
UniGeneiBt.23192.

Genome annotation databases

EnsembliENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248.
GeneIDi326600.
KEGGibta:326600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021526 mRNA. Translation: AAX46373.1.
BT021895 mRNA. Translation: AAX46742.1.
BT026160 mRNA. Translation: ABG66999.1.
BC102942 mRNA. Translation: AAI02943.1.
RefSeqiNP_001014844.1. NM_001014844.3.
UniGeneiBt.23192.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00C1-372[»]
1TYQX-ray2.55C1-372[»]
1U2VX-ray2.55C1-372[»]
2P9IX-ray2.46C1-372[»]
2P9KX-ray2.59C1-372[»]
2P9LX-ray2.65C1-372[»]
2P9NX-ray2.85C1-372[»]
2P9PX-ray2.90C1-372[»]
2P9SX-ray2.68C1-372[»]
2P9UX-ray2.75C1-372[»]
3DXKX-ray2.70C1-372[»]
3DXMX-ray2.85C1-372[»]
3RSEX-ray2.65C1-372[»]
3UKRX-ray2.48C1-372[»]
3UKUX-ray2.75C1-372[»]
3ULEX-ray2.50C1-372[»]
4JD2X-ray3.08C1-372[»]
ProteinModelPortaliQ58CQ2.
SMRiQ58CQ2. Positions 2-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29791N.

Proteomic databases

PaxDbiQ58CQ2.
PRIDEiQ58CQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248.
GeneIDi326600.
KEGGibta:326600.

Organism-specific databases

CTDi10095.

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ58CQ2.
KOiK05757.
OMAiVLFTYDS.
OrthoDBiEOG77DJ62.
TreeFamiTF315041.

Miscellaneous databases

EvolutionaryTraceiQ58CQ2.
NextBioi20809662.

Gene expression databases

ExpressionAtlasiQ58CQ2. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030141. ARC1B.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF10. PTHR10709:SF10. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
  4. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARC1B_BOVIN
AccessioniPrimary (citable) accession number: Q58CQ2
Secondary accession number(s): Q0V8Q8, Q58DS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 89 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.