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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

ARPC1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:26164 ARPC1B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397011 – 372Actin-related protein 2/3 complex subunit 1BAdd BLAST372

Proteomic databases

PaxDbiQ58CQ2
PeptideAtlasiQ58CQ2
PRIDEiQ58CQ2

Expressioni

Gene expression databases

BgeeiENSBTAG00000046248

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29791N
IntActiQ58CQ2, 8 interactors
STRINGi9913.ENSBTAP00000056302

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi14 – 16Combined sources3
Beta strandi20 – 25Combined sources6
Beta strandi28 – 38Combined sources11
Beta strandi41 – 49Combined sources9
Beta strandi55 – 61Combined sources7
Turni62 – 65Combined sources4
Beta strandi66 – 71Combined sources6
Beta strandi72 – 74Combined sources3
Beta strandi76 – 82Combined sources7
Beta strandi85 – 91Combined sources7
Beta strandi99 – 104Combined sources6
Beta strandi108 – 115Combined sources8
Beta strandi118 – 126Combined sources9
Turni127 – 130Combined sources4
Beta strandi131 – 137Combined sources7
Beta strandi145 – 150Combined sources6
Beta strandi154 – 161Combined sources8
Beta strandi166 – 170Combined sources5
Turni174 – 176Combined sources3
Beta strandi194 – 197Combined sources4
Beta strandi201 – 203Combined sources3
Beta strandi205 – 210Combined sources6
Beta strandi212 – 221Combined sources10
Turni222 – 224Combined sources3
Beta strandi225 – 230Combined sources6
Helixi231 – 233Combined sources3
Beta strandi237 – 241Combined sources5
Beta strandi243 – 245Combined sources3
Beta strandi247 – 254Combined sources8
Beta strandi257 – 262Combined sources6
Beta strandi268 – 273Combined sources6
Turni274 – 277Combined sources4
Beta strandi278 – 281Combined sources4
Helixi298 – 304Combined sources7
Beta strandi322 – 327Combined sources6
Beta strandi329 – 337Combined sources9
Turni338 – 340Combined sources3
Beta strandi343 – 349Combined sources7
Beta strandi352 – 358Combined sources7
Helixi359 – 365Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00C1-372[»]
1TYQX-ray2.55C1-372[»]
1U2VX-ray2.55C1-372[»]
2P9IX-ray2.46C1-372[»]
2P9KX-ray2.59C1-372[»]
2P9LX-ray2.65C1-372[»]
2P9NX-ray2.85C1-372[»]
2P9PX-ray2.90C1-372[»]
2P9SX-ray2.68C1-372[»]
2P9UX-ray2.75C1-372[»]
3DXKX-ray2.70C1-372[»]
3DXMX-ray2.85C1-372[»]
3RSEX-ray2.65C1-372[»]
3UKRX-ray2.48C1-372[»]
3UKUX-ray2.75C1-372[»]
3ULEX-ray2.50C1-372[»]
4JD2X-ray3.08C1-372[»]
4XEIX-ray3.87C1-372[»]
4XF2X-ray5.00C/V1-372[»]
ProteinModelPortaliQ58CQ2
SMRiQ58CQ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58CQ2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati94 – 135WD 3Add BLAST42
Repeati140 – 179WD 4Add BLAST40
Repeati242 – 280WD 5Add BLAST39
Repeati324 – 367WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiQ58CQ2
KOiK05757
OMAiVLFTYDS
OrthoDBiEOG091G096H
TreeFamiTF315041

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q58CQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE
60 70 80 90 100
HNGQVTGIDW APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNEKK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNSVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVR SLESALKDLK IV
Length:372
Mass (Da):40,976
Last modified:January 23, 2007 - v4
Checksum:iB412F9C50DC93748
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66R → H in AAX46742 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021526 mRNA Translation: AAX46373.1
BT021895 mRNA Translation: AAX46742.1
BT026160 mRNA Translation: ABG66999.1
BC102942 mRNA Translation: AAI02943.1
RefSeqiNP_001014844.1, NM_001014844.3
UniGeneiBt.23192

Genome annotation databases

EnsembliENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248
GeneIDi326600
KEGGibta:326600

Similar proteinsi

Entry informationi

Entry nameiARC1B_BOVIN
AccessioniPrimary (citable) accession number: Q58CQ2
Secondary accession number(s): Q0V8Q8, Q58DS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 110 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health