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Q58CQ2

- ARC1B_BOVIN

UniProt

Q58CQ2 - ARC1B_BOVIN

Protein

Actin-related protein 2/3 complex subunit 1B

Gene

ARPC1B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

    GO - Biological processi

    1. regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 2/3 complex subunit 1B
    Alternative name(s):
    Arp2/3 complex 41 kDa subunit
    p41-ARC
    Gene namesi
    Name:ARPC1B
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 372371Actin-related protein 2/3 complex subunit 1BPRO_0000239701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ58CQ2.
    PRIDEiQ58CQ2.

    Interactioni

    Subunit structurei

    Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Protein-protein interaction databases

    DIPiDIP-29791N.

    Structurei

    Secondary structure

    1
    372
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 64
    Beta strandi14 – 163
    Beta strandi20 – 256
    Beta strandi28 – 3811
    Beta strandi41 – 499
    Beta strandi55 – 617
    Turni62 – 654
    Beta strandi66 – 716
    Beta strandi72 – 743
    Beta strandi76 – 827
    Beta strandi85 – 917
    Beta strandi99 – 1046
    Beta strandi108 – 1158
    Beta strandi118 – 1269
    Turni127 – 1304
    Beta strandi131 – 1377
    Beta strandi145 – 1506
    Beta strandi154 – 1618
    Beta strandi166 – 1705
    Turni174 – 1763
    Beta strandi194 – 1974
    Beta strandi201 – 2033
    Beta strandi205 – 2106
    Beta strandi212 – 22110
    Turni222 – 2243
    Beta strandi225 – 2306
    Helixi231 – 2333
    Beta strandi237 – 2415
    Beta strandi243 – 2453
    Beta strandi247 – 2548
    Beta strandi257 – 2626
    Beta strandi268 – 2736
    Turni274 – 2774
    Beta strandi278 – 2814
    Helixi298 – 3047
    Beta strandi322 – 3276
    Beta strandi329 – 3379
    Turni338 – 3403
    Beta strandi343 – 3497
    Beta strandi352 – 3587
    Helixi359 – 3657

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K8KX-ray2.00C1-372[»]
    1TYQX-ray2.55C1-372[»]
    1U2VX-ray2.55C1-372[»]
    2P9IX-ray2.46C1-372[»]
    2P9KX-ray2.59C1-372[»]
    2P9LX-ray2.65C1-372[»]
    2P9NX-ray2.85C1-372[»]
    2P9PX-ray2.90C1-372[»]
    2P9SX-ray2.68C1-372[»]
    2P9UX-ray2.75C1-372[»]
    3DXKX-ray2.70C1-372[»]
    3DXMX-ray2.85C1-372[»]
    3RSEX-ray2.65C1-372[»]
    3UKRX-ray2.48C1-372[»]
    3UKUX-ray2.75C1-372[»]
    3ULEX-ray2.50C1-372[»]
    4JD2X-ray3.08C1-372[»]
    ProteinModelPortaliQ58CQ2.
    SMRiQ58CQ2. Positions 2-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ58CQ2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 4540WD 1Add
    BLAST
    Repeati50 – 8940WD 2Add
    BLAST
    Repeati94 – 13542WD 3Add
    BLAST
    Repeati140 – 17940WD 4Add
    BLAST
    Repeati242 – 28039WD 5Add
    BLAST
    Repeati324 – 36744WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat ARPC1 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00390000008339.
    HOGENOMiHOG000181752.
    HOVERGENiHBG050560.
    InParanoidiQ58CQ2.
    KOiK05757.
    OMAiKWVKVHE.
    OrthoDBiEOG77DJ62.
    TreeFamiTF315041.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR017383. ARPC2/3_su1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR10709. PTHR10709. 1 hit.
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58CQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE    50
    HNGQVTGIDW APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR 100
    CVRWAPNEKK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW 150
    HPNSVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS 200
    SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAV 250
    TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE 300
    RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM 350
    DGGMSIWDVR SLESALKDLK IV 372
    Length:372
    Mass (Da):40,976
    Last modified:January 23, 2007 - v4
    Checksum:iB412F9C50DC93748
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661R → H in AAX46742. (PubMed:16305752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021526 mRNA. Translation: AAX46373.1.
    BT021895 mRNA. Translation: AAX46742.1.
    BT026160 mRNA. Translation: ABG66999.1.
    BC102942 mRNA. Translation: AAI02943.1.
    RefSeqiNP_001014844.1. NM_001014844.3.
    UniGeneiBt.23192.

    Genome annotation databases

    EnsembliENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248.
    GeneIDi326600.
    KEGGibta:326600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021526 mRNA. Translation: AAX46373.1 .
    BT021895 mRNA. Translation: AAX46742.1 .
    BT026160 mRNA. Translation: ABG66999.1 .
    BC102942 mRNA. Translation: AAI02943.1 .
    RefSeqi NP_001014844.1. NM_001014844.3.
    UniGenei Bt.23192.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K8K X-ray 2.00 C 1-372 [» ]
    1TYQ X-ray 2.55 C 1-372 [» ]
    1U2V X-ray 2.55 C 1-372 [» ]
    2P9I X-ray 2.46 C 1-372 [» ]
    2P9K X-ray 2.59 C 1-372 [» ]
    2P9L X-ray 2.65 C 1-372 [» ]
    2P9N X-ray 2.85 C 1-372 [» ]
    2P9P X-ray 2.90 C 1-372 [» ]
    2P9S X-ray 2.68 C 1-372 [» ]
    2P9U X-ray 2.75 C 1-372 [» ]
    3DXK X-ray 2.70 C 1-372 [» ]
    3DXM X-ray 2.85 C 1-372 [» ]
    3RSE X-ray 2.65 C 1-372 [» ]
    3UKR X-ray 2.48 C 1-372 [» ]
    3UKU X-ray 2.75 C 1-372 [» ]
    3ULE X-ray 2.50 C 1-372 [» ]
    4JD2 X-ray 3.08 C 1-372 [» ]
    ProteinModelPortali Q58CQ2.
    SMRi Q58CQ2. Positions 2-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29791N.

    Proteomic databases

    PaxDbi Q58CQ2.
    PRIDEi Q58CQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000064158 ; ENSBTAP00000056302 ; ENSBTAG00000046248 .
    GeneIDi 326600.
    KEGGi bta:326600.

    Organism-specific databases

    CTDi 10095.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00390000008339.
    HOGENOMi HOG000181752.
    HOVERGENi HBG050560.
    InParanoidi Q58CQ2.
    KOi K05757.
    OMAi KWVKVHE.
    OrthoDBi EOG77DJ62.
    TreeFami TF315041.

    Enzyme and pathway databases

    Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    EvolutionaryTracei Q58CQ2.
    NextBioi 20809662.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR017383. ARPC2/3_su1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR10709. PTHR10709. 1 hit.
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038093. ARP2/3_su1. 1 hit.
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
    4. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
      Nolen B.J., Littlefield R.S., Pollard T.D.
      Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

    Entry informationi

    Entry nameiARC1B_BOVIN
    AccessioniPrimary (citable) accession number: Q58CQ2
    Secondary accession number(s): Q0V8Q8, Q58DS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3