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Q58CQ2

- ARC1B_BOVIN

UniProt

Q58CQ2 - ARC1B_BOVIN

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Protein
Actin-related protein 2/3 complex subunit 1B
Gene
ARPC1B
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

GO - Biological processi

  1. regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 372371Actin-related protein 2/3 complex subunit 1B
PRO_0000239701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ58CQ2.
PRIDEiQ58CQ2.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29791N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64
Beta strandi14 – 163
Beta strandi20 – 256
Beta strandi28 – 3811
Beta strandi41 – 499
Beta strandi55 – 617
Turni62 – 654
Beta strandi66 – 716
Beta strandi72 – 743
Beta strandi76 – 827
Beta strandi85 – 917
Beta strandi99 – 1046
Beta strandi108 – 1158
Beta strandi118 – 1269
Turni127 – 1304
Beta strandi131 – 1377
Beta strandi145 – 1506
Beta strandi154 – 1618
Beta strandi166 – 1705
Turni174 – 1763
Beta strandi194 – 1974
Beta strandi201 – 2033
Beta strandi205 – 2106
Beta strandi212 – 22110
Turni222 – 2243
Beta strandi225 – 2306
Helixi231 – 2333
Beta strandi237 – 2415
Beta strandi243 – 2453
Beta strandi247 – 2548
Beta strandi257 – 2626
Beta strandi268 – 2736
Turni274 – 2774
Beta strandi278 – 2814
Helixi298 – 3047
Beta strandi322 – 3276
Beta strandi329 – 3379
Turni338 – 3403
Beta strandi343 – 3497
Beta strandi352 – 3587
Helixi359 – 3657

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00C1-372[»]
1TYQX-ray2.55C1-372[»]
1U2VX-ray2.55C1-372[»]
2P9IX-ray2.46C1-372[»]
2P9KX-ray2.59C1-372[»]
2P9LX-ray2.65C1-372[»]
2P9NX-ray2.85C1-372[»]
2P9PX-ray2.90C1-372[»]
2P9SX-ray2.68C1-372[»]
2P9UX-ray2.75C1-372[»]
3DXKX-ray2.70C1-372[»]
3DXMX-ray2.85C1-372[»]
3RSEX-ray2.65C1-372[»]
3UKRX-ray2.48C1-372[»]
3UKUX-ray2.75C1-372[»]
3ULEX-ray2.50C1-372[»]
4JD2X-ray3.08C1-372[»]
ProteinModelPortaliQ58CQ2.
SMRiQ58CQ2. Positions 2-372.

Miscellaneous databases

EvolutionaryTraceiQ58CQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1
Add
BLAST
Repeati50 – 8940WD 2
Add
BLAST
Repeati94 – 13542WD 3
Add
BLAST
Repeati140 – 17940WD 4
Add
BLAST
Repeati242 – 28039WD 5
Add
BLAST
Repeati324 – 36744WD 6
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ58CQ2.
KOiK05757.
OMAiKWVKVHE.
OrthoDBiEOG77DJ62.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58CQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE    50
HNGQVTGIDW APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR 100
CVRWAPNEKK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW 150
HPNSVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS 200
SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAV 250
TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE 300
RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM 350
DGGMSIWDVR SLESALKDLK IV 372
Length:372
Mass (Da):40,976
Last modified:January 23, 2007 - v4
Checksum:iB412F9C50DC93748
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661R → H in AAX46742. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021526 mRNA. Translation: AAX46373.1.
BT021895 mRNA. Translation: AAX46742.1.
BT026160 mRNA. Translation: ABG66999.1.
BC102942 mRNA. Translation: AAI02943.1.
RefSeqiNP_001014844.1. NM_001014844.3.
UniGeneiBt.23192.

Genome annotation databases

EnsembliENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248.
GeneIDi326600.
KEGGibta:326600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021526 mRNA. Translation: AAX46373.1 .
BT021895 mRNA. Translation: AAX46742.1 .
BT026160 mRNA. Translation: ABG66999.1 .
BC102942 mRNA. Translation: AAI02943.1 .
RefSeqi NP_001014844.1. NM_001014844.3.
UniGenei Bt.23192.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 C 1-372 [» ]
1TYQ X-ray 2.55 C 1-372 [» ]
1U2V X-ray 2.55 C 1-372 [» ]
2P9I X-ray 2.46 C 1-372 [» ]
2P9K X-ray 2.59 C 1-372 [» ]
2P9L X-ray 2.65 C 1-372 [» ]
2P9N X-ray 2.85 C 1-372 [» ]
2P9P X-ray 2.90 C 1-372 [» ]
2P9S X-ray 2.68 C 1-372 [» ]
2P9U X-ray 2.75 C 1-372 [» ]
3DXK X-ray 2.70 C 1-372 [» ]
3DXM X-ray 2.85 C 1-372 [» ]
3RSE X-ray 2.65 C 1-372 [» ]
3UKR X-ray 2.48 C 1-372 [» ]
3UKU X-ray 2.75 C 1-372 [» ]
3ULE X-ray 2.50 C 1-372 [» ]
4JD2 X-ray 3.08 C 1-372 [» ]
ProteinModelPortali Q58CQ2.
SMRi Q58CQ2. Positions 2-372.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-29791N.

Proteomic databases

PaxDbi Q58CQ2.
PRIDEi Q58CQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000064158 ; ENSBTAP00000056302 ; ENSBTAG00000046248 .
GeneIDi 326600.
KEGGi bta:326600.

Organism-specific databases

CTDi 10095.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00390000008339.
HOGENOMi HOG000181752.
HOVERGENi HBG050560.
InParanoidi Q58CQ2.
KOi K05757.
OMAi KWVKVHE.
OrthoDBi EOG77DJ62.
TreeFami TF315041.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q58CQ2.
NextBioi 20809662.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10709. PTHR10709. 1 hit.
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
PIRSFi PIRSF038093. ARP2/3_su1. 1 hit.
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
  4. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARC1B_BOVIN
AccessioniPrimary (citable) accession number: Q58CQ2
Secondary accession number(s): Q0V8Q8, Q58DS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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