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Q58CQ2 (ARC1B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene names
Name:ARPC1B
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Sequence similarities

Belongs to the WD repeat ARPC1 family.

Contains 6 WD repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
WD repeat
   LigandActin-binding
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of actin filament polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionactin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 372371Actin-related protein 2/3 complex subunit 1B
PRO_0000239701

Regions

Repeat6 – 4540WD 1
Repeat50 – 8940WD 2
Repeat94 – 13542WD 3
Repeat140 – 17940WD 4
Repeat242 – 28039WD 5
Repeat324 – 36744WD 6

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue821N6-acetyllysine By similarity
Modified residue3101Phosphoserine By similarity

Experimental info

Sequence conflict661R → H in AAX46742. Ref.1

Secondary structure

1 .................................................................. 372
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58CQ2 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: B412F9C50DC93748

FASTA37240,976
        10         20         30         40         50         60 
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE HNGQVTGIDW 

        70         80         90        100        110        120 
APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNEKK FAVGSGSRVI 

       130        140        150        160        170        180 
SICYFEQEND WWVCKHIKKP IRSTVLSLDW HPNSVLLAAG SCDFKCRIFS AYIKEVEERP 

       190        200        210        220        230        240 
APTPWGSKMP FGELMFESSS SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL 

       250        260        270        280        290        300 
ASETLPLLAV TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE 

       310        320        330        340        350        360 
RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM DGGMSIWDVR 

       370 
SLESALKDLK IV

« Hide

References

« Hide 'large scale' references
[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[3]"Crystal structure of Arp2/3 complex."
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N., Choe S., Pollard T.D.
Science 294:1679-1684(2001) [PubMed: 11721045] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF THE ARP2/3 COMPLEX.
[4]"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
Nolen B.J., Littlefield R.S., Pollard T.D.
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed: 15505213] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF THE ARP2/3 COMPLEX WITH BOUND ATP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT021526 mRNA. Translation: AAX46373.1.
BT021895 mRNA. Translation: AAX46742.1.
BT026160 mRNA. Translation: ABG66999.1.
BC102942 mRNA. Translation: AAI02943.1.
IPIIPI00693939.
RefSeqNP_001014844.1. NM_001014844.2.
UniGeneBt.105856.
Bt.23192.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00C1-372[»]
1TYQX-ray2.55C1-372[»]
1U2VX-ray2.55C1-372[»]
2P9IX-ray2.46C1-372[»]
2P9KX-ray2.59C1-372[»]
2P9LX-ray2.65C1-372[»]
2P9NX-ray2.85C1-372[»]
2P9PX-ray2.90C1-372[»]
2P9SX-ray2.68C1-372[»]
2P9UX-ray2.75C1-372[»]
3DXKX-ray2.70C1-372[»]
3DXMX-ray2.85C1-372[»]
3RSEX-ray2.65C1-372[»]
ProteinModelPortalQ58CQ2.
SMRQ58CQ2. Positions 2-372.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29791N.
STRINGQ58CQ2.

Proteomic databases

PRIDEQ58CQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248.
GeneID326600.
KEGGbta:326600.

Organism-specific databases

CTD10095.

Phylogenomic databases

GeneTreeENSGT00390000008339.
HOVERGENHBG050560.
InParanoidQ58CQ2.
OrthoDBEOG4NZTTG.
PhylomeDBQ58CQ2.

Family and domain databases

InterProIPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KOK05757.
PANTHERPTHR10709. PTHR10709. 1 hit.
PfamPF00400. WD40. 5 hits.
[Graphical view]
PIRSFPIRSF038093. ARP2/3_su1. 1 hit.
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARC1B_BOVIN
AccessionPrimary (citable) accession number: Q58CQ2
Secondary accession number(s): Q0V8Q8, Q58DS1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 64 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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