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Q58CP0

- IDH3G_BOVIN

UniProt

Q58CP0 - IDH3G_BOVIN

Protein

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Gene

IDH3G

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Enzyme regulationi

    Activated by increasing ADP/ATP ratios and by Ca2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351SubstrateBy similarity
    Binding sitei166 – 1661SubstrateBy similarity
    Sitei173 – 1731Critical for catalysisBy similarity
    Sitei220 – 2201Critical for catalysisBy similarity
    Metal bindingi253 – 2531Magnesium or manganeseBy similarity
    Binding sitei253 – 2531SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi55 – 8329NADSequence AnalysisAdd
    BLAST
    Nucleotide bindingi308 – 3158ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
    3. magnesium ion binding Source: InterPro
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: UniProtKB
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_227707. Citric acid cycle (TCA cycle).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit gamma
    NAD(+)-specific ICDH subunit gamma
    Gene namesi
    Name:IDH3G
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: AgBase
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionBy similarityAdd
    BLAST
    Chaini40 – 392353Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialPRO_0000236185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251N6-succinyllysineBy similarity

    Proteomic databases

    PRIDEiQ58CP0.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ58CP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    GeneTreeiENSGT00590000083091.
    HOGENOMiHOG000021113.
    HOVERGENiHBG052080.
    InParanoidiQ58CP0.
    KOiK00030.
    OMAiNETRLHT.
    TreeFamiTF315033.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58CP0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKVATAAG GAVKAALRPA LLWRPWEVLG SHEAPRRSFS QQTIPPSAKY    50
    GGRHTVTMIP GDGIGPELML HVKSVFRHAC VPVDFEEVHV SSTADEEDIR 100
    NAIMAIRRNR VALKGNIETN HNLPPSHKSR NNILRTSLDL YANVIHCKSL 150
    PGVVTRHRDI DILIVRENTE GEYSSLEHES VAGVVESLKI ITKAKSLRIA 200
    EYAFQLAQES GRKKVTAVHK ANIMKLGDGL FLQCCREVAA RYPQITFENM 250
    IVDNTTMQLV SRPQQFDVMV MPNLYGNIVN NVCAGLVGGP GLVAGANYGH 300
    VYAVFETATR NTGKSIANKN IANPTATLLA SCMMLDHLKL HSYATSIRKA 350
    VLASMDNENM HTPDIGGQGT TSEAIQDIIR HIRVINGRAV EA 392
    Length:392
    Mass (Da):42,863
    Last modified:April 26, 2005 - v1
    Checksum:i44F749F782E18EFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021907 mRNA. Translation: AAX46754.1.
    BC118275 mRNA. Translation: AAI18276.1.
    RefSeqiNP_001069781.1. NM_001076313.1.
    UniGeneiBt.23357.

    Genome annotation databases

    EnsembliENSBTAT00000001405; ENSBTAP00000001405; ENSBTAG00000001059.
    GeneIDi614145.
    KEGGibta:614145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021907 mRNA. Translation: AAX46754.1 .
    BC118275 mRNA. Translation: AAI18276.1 .
    RefSeqi NP_001069781.1. NM_001076313.1.
    UniGenei Bt.23357.

    3D structure databases

    ProteinModelPortali Q58CP0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q58CP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001405 ; ENSBTAP00000001405 ; ENSBTAG00000001059 .
    GeneIDi 614145.
    KEGGi bta:614145.

    Organism-specific databases

    CTDi 3421.

    Phylogenomic databases

    eggNOGi COG0473.
    GeneTreei ENSGT00590000083091.
    HOGENOMi HOG000021113.
    HOVERGENi HBG052080.
    InParanoidi Q58CP0.
    KOi K00030.
    OMAi NETRLHT.
    TreeFami TF315033.

    Enzyme and pathway databases

    Reactomei REACT_227707. Citric acid cycle (TCA cycle).

    Miscellaneous databases

    NextBioi 20898963.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiIDH3G_BOVIN
    AccessioniPrimary (citable) accession number: Q58CP0
    Secondary accession number(s): Q148J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3