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Protein

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Gene

IDH3G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Enzyme regulationi

Activated by increasing ADP/ATP ratios and by Ca2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei166 – 1661SubstrateBy similarity
Sitei173 – 1731Critical for catalysisBy similarity
Sitei220 – 2201Critical for catalysisBy similarity
Metal bindingi253 – 2531Magnesium or manganeseBy similarity
Binding sitei253 – 2531SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 8329NADSequence AnalysisAdd
BLAST
Nucleotide bindingi308 – 3158ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  3. magnesium ion binding Source: InterPro
  4. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: UniProtKB
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_347675. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene namesi
Name:IDH3G
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome X

Subcellular locationi

  1. Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: AgBase
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionBy similarityAdd
BLAST
Chaini40 – 392353Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialPRO_0000236185Add
BLAST

Proteomic databases

PRIDEiQ58CP0.

Expressioni

Gene expression databases

ExpressionAtlasiQ58CP0. baseline and differential.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
InParanoidiQ58CP0.
KOiK00030.
OMAiLRPCKTY.
TreeFamiTF315033.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58CP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKVATAAG GAVKAALRPA LLWRPWEVLG SHEAPRRSFS QQTIPPSAKY
60 70 80 90 100
GGRHTVTMIP GDGIGPELML HVKSVFRHAC VPVDFEEVHV SSTADEEDIR
110 120 130 140 150
NAIMAIRRNR VALKGNIETN HNLPPSHKSR NNILRTSLDL YANVIHCKSL
160 170 180 190 200
PGVVTRHRDI DILIVRENTE GEYSSLEHES VAGVVESLKI ITKAKSLRIA
210 220 230 240 250
EYAFQLAQES GRKKVTAVHK ANIMKLGDGL FLQCCREVAA RYPQITFENM
260 270 280 290 300
IVDNTTMQLV SRPQQFDVMV MPNLYGNIVN NVCAGLVGGP GLVAGANYGH
310 320 330 340 350
VYAVFETATR NTGKSIANKN IANPTATLLA SCMMLDHLKL HSYATSIRKA
360 370 380 390
VLASMDNENM HTPDIGGQGT TSEAIQDIIR HIRVINGRAV EA
Length:392
Mass (Da):42,863
Last modified:April 26, 2005 - v1
Checksum:i44F749F782E18EFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021907 mRNA. Translation: AAX46754.1.
BC118275 mRNA. Translation: AAI18276.1.
RefSeqiNP_001069781.1. NM_001076313.1.
UniGeneiBt.23357.

Genome annotation databases

EnsembliENSBTAT00000001405; ENSBTAP00000001405; ENSBTAG00000001059.
GeneIDi614145.
KEGGibta:614145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021907 mRNA. Translation: AAX46754.1.
BC118275 mRNA. Translation: AAI18276.1.
RefSeqiNP_001069781.1. NM_001076313.1.
UniGeneiBt.23357.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ58CP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001405; ENSBTAP00000001405; ENSBTAG00000001059.
GeneIDi614145.
KEGGibta:614145.

Organism-specific databases

CTDi3421.

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
InParanoidiQ58CP0.
KOiK00030.
OMAiLRPCKTY.
TreeFamiTF315033.

Enzyme and pathway databases

ReactomeiREACT_347675. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi20898963.

Gene expression databases

ExpressionAtlasiQ58CP0. baseline and differential.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiIDH3G_BOVIN
AccessioniPrimary (citable) accession number: Q58CP0
Secondary accession number(s): Q148J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: April 1, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.