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Q58CP0

- IDH3G_BOVIN

UniProt

Q58CP0 - IDH3G_BOVIN

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Protein
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Gene
IDH3G
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulationi

Activated by increasing ADP/ATP ratios and by Ca2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Sitei173 – 1731Critical for catalysis By similarity
Sitei220 – 2201Critical for catalysis By similarity
Metal bindingi253 – 2531Magnesium or manganese By similarity
Binding sitei253 – 2531Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 8329NAD Reviewed prediction
Add
BLAST
Nucleotide bindingi308 – 3158ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD binding Source: InterPro
  3. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  4. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: UniProtKB
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_227707. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma
NAD(+)-specific ICDH subunit gamma
Gene namesi
Name:IDH3G
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: AgBase
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion By similarity
Add
BLAST
Chaini40 – 392353Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
PRO_0000236185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251N6-succinyllysine By similarity

Proteomic databases

PRIDEiQ58CP0.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ58CP0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
InParanoidiQ58CP0.
KOiK00030.
OMAiNETRLHT.
TreeFamiTF315033.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58CP0-1 [UniParc]FASTAAdd to Basket

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MALKVATAAG GAVKAALRPA LLWRPWEVLG SHEAPRRSFS QQTIPPSAKY    50
GGRHTVTMIP GDGIGPELML HVKSVFRHAC VPVDFEEVHV SSTADEEDIR 100
NAIMAIRRNR VALKGNIETN HNLPPSHKSR NNILRTSLDL YANVIHCKSL 150
PGVVTRHRDI DILIVRENTE GEYSSLEHES VAGVVESLKI ITKAKSLRIA 200
EYAFQLAQES GRKKVTAVHK ANIMKLGDGL FLQCCREVAA RYPQITFENM 250
IVDNTTMQLV SRPQQFDVMV MPNLYGNIVN NVCAGLVGGP GLVAGANYGH 300
VYAVFETATR NTGKSIANKN IANPTATLLA SCMMLDHLKL HSYATSIRKA 350
VLASMDNENM HTPDIGGQGT TSEAIQDIIR HIRVINGRAV EA 392
Length:392
Mass (Da):42,863
Last modified:April 26, 2005 - v1
Checksum:i44F749F782E18EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021907 mRNA. Translation: AAX46754.1.
BC118275 mRNA. Translation: AAI18276.1.
RefSeqiNP_001069781.1. NM_001076313.1.
UniGeneiBt.23357.

Genome annotation databases

EnsembliENSBTAT00000001405; ENSBTAP00000001405; ENSBTAG00000001059.
GeneIDi614145.
KEGGibta:614145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021907 mRNA. Translation: AAX46754.1 .
BC118275 mRNA. Translation: AAI18276.1 .
RefSeqi NP_001069781.1. NM_001076313.1.
UniGenei Bt.23357.

3D structure databases

ProteinModelPortali Q58CP0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q58CP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001405 ; ENSBTAP00000001405 ; ENSBTAG00000001059 .
GeneIDi 614145.
KEGGi bta:614145.

Organism-specific databases

CTDi 3421.

Phylogenomic databases

eggNOGi COG0473.
GeneTreei ENSGT00590000083091.
HOGENOMi HOG000021113.
HOVERGENi HBG052080.
InParanoidi Q58CP0.
KOi K00030.
OMAi NETRLHT.
TreeFami TF315033.

Enzyme and pathway databases

Reactomei REACT_227707. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi 20898963.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiIDH3G_BOVIN
AccessioniPrimary (citable) accession number: Q58CP0
Secondary accession number(s): Q148J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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