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Q58A65

- JIP4_MOUSE

UniProt

Q58A65 - JIP4_MOUSE

Protein

C-Jun-amino-terminal kinase-interacting protein 4

Gene

Spag9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.2 Publications

    GO - Molecular functioni

    1. JUN kinase binding Source: MGI
    2. kinesin binding Source: MGI
    3. mitogen-activated protein kinase p38 binding Source: MGI
    4. protein binding Source: IntAct

    GO - Biological processi

    1. activation of JUN kinase activity Source: MGI
    2. activation of MAPK activity Source: MGI
    3. negative regulation of protein homodimerization activity Source: MGI
    4. positive regulation of cell migration Source: Ensembl
    5. positive regulation of MAPK cascade Source: MGI
    6. positive regulation of neuron differentiation Source: MGI
    7. protein homooligomerization Source: MGI
    8. retrograde transport, endosome to Golgi Source: Ensembl
    9. striated muscle cell differentiation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 4
    Short name:
    JIP-4
    Short name:
    JNK-interacting protein 4
    Alternative name(s):
    JNK-associated leucine-zipper protein
    Short name:
    JLP
    JNK/SAPK-associated protein 2
    Short name:
    JSAP2
    Mitogen-activated protein kinase 8-interacting protein 4
    Sperm-associated antigen 9
    Gene namesi
    Name:Spag9
    Synonyms:Jip4, Jsap2, Kiaa0516, Mapk8ip4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1918084. Spag9.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region
    Note: Perinuclear distribution in response to stress signals such as UV radiation.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: Reactome
    3. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13211321C-Jun-amino-terminal kinase-interacting protein 4PRO_0000234077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei109 – 1091PhosphoserineBy similarity
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei185 – 1851PhosphoserineBy similarity
    Modified residuei194 – 1941PhosphoserineBy similarity
    Modified residuei203 – 2031PhosphoserineBy similarity
    Modified residuei217 – 2171Phosphothreonine2 Publications
    Modified residuei251 – 2511PhosphoserineBy similarity
    Modified residuei265 – 2651PhosphoserineBy similarity
    Modified residuei268 – 2681PhosphoserineBy similarity
    Modified residuei272 – 2721PhosphoserineBy similarity
    Modified residuei311 – 3111PhosphoserineBy similarity
    Modified residuei329 – 3291PhosphoserineBy similarity
    Modified residuei332 – 3321PhosphoserineBy similarity
    Modified residuei347 – 3471PhosphoserineBy similarity
    Modified residuei348 – 3481PhosphothreonineBy similarity
    Modified residuei365 – 3651Phosphothreonine2 Publications
    Modified residuei418 – 4181PhosphothreonineBy similarity
    Modified residuei586 – 5861PhosphothreonineBy similarity
    Modified residuei730 – 7301PhosphoserineBy similarity
    Modified residuei733 – 7331Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by MAPK8 and MAPK14.3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ58A65.
    PaxDbiQ58A65.
    PRIDEiQ58A65.

    PTM databases

    PhosphoSiteiQ58A65.

    Expressioni

    Tissue specificityi

    Isoform 6 is highly expressed in brain, kidney, liver, heart.1 Publication

    Inductioni

    Up-regulated during neuronal differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ58A65.
    BgeeiQ58A65.
    CleanExiMM_SPAG9.
    GenevestigatoriQ58A65.

    Interactioni

    Subunit structurei

    Homodimer. The homodimer interacts with ARF6, forming a heterotetramer By similarity. Homooligomer. Interacts with MAX, MAPK8, MAPK14, MAPK10, MAPK14, MAP3K3, MYC, KNS2, and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arf6P6233110EBI-6530207,EBI-988682
    LRRK2Q5S0072EBI-6530207,EBI-5323863From a different organism.

    Protein-protein interaction databases

    BioGridi214283. 5 interactions.
    IntActiQ58A65. 3 interactions.
    MINTiMINT-1351345.
    STRINGi10090.ENSMUSP00000099458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58A65.
    SMRiQ58A65. Positions 406-466, 1001-1026.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili66 – 166101Sequence AnalysisAdd
    BLAST
    Coiled coili408 – 534127By similarityAdd
    BLAST
    Coiled coili724 – 75835Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the JIP scaffold family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270333.
    GeneTreeiENSGT00670000097546.
    HOVERGENiHBG024110.
    InParanoidiQ58A65.
    OMAiGSDQLES.
    OrthoDBiEOG7GXP9P.
    PhylomeDBiQ58A65.
    TreeFamiTF313096.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR019143. JNK/Rab-associated_protein-1_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF09744. Jnk-SapK_ap_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q58A65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELEDGVVYQ EEPGGSGAVM SERVSGLAGS IYREFERLIG RYDEEVVKEL     50
    MPLVVAVLEN LDSVFAQDQE HQVELELLRD DNEQLITQYE REKALRKHAE 100
    EKFIEFEDSQ EQEKKDLQTR VESLESQTRQ LELKAKNYAD QISRLEEREA 150
    ELKKEYNALH QRHTEMIHNY MEHLERTKLH QLSGSDQLEA TAHSRIRKER 200
    PISLGIFPLP AGDGLLTPDT QKGGETPGSE QWKFQELSQP RSHTSLKVSH 250
    SPEPPKAVEQ EDELSDISQG GSKATTPAST ANSDVSAIPP DTPSKEDNEG 300
    FVKGTDTSNK SEISKHIEVQ VAQETRNVST ESGENEEKSE VQAIIESTPE 350
    LDMDKDLSGY KGSSTPTKGI ENKAFDRNTE SLFEELSSAG SGLIGDVDEG 400
    ADLLGMGREV ENLILENTQL LETKNALNVV KNDLIAKVDE LTCEKDVLQG 450
    ELEAVKQAKL KLEDKNRELE EELRKARAEA EDARQKAKDD DDSDIPTAQR 500
    KRFTRVEMAR VLMERNQYKE RLMELQEAVR WTEMIRASRE NPAMQEKKRS 550
    SIWQFFSRLF SSSSNATKKP EPPVNLKYNA PTSHVTPSVK KRSSTLSQLP 600
    GDKSKAFDFL SEETEASLAS RREQKREQYR QVKAHVQKED GRVQAFGWSL 650
    PQKYKQVANG QGETKMKNLP VPVYLRPLDE KDASMKLWCA VGVNLSGGKT 700
    RDGGSVVGAS VFYKDIAGLD TEGSKQRSAS QSSLDKLDQE LKEQQKEFKN 750
    QEELSSQVWI CTSTHSTTKV IIIDAVQPGN ILDSFTVCNS HVLCIASVPG 800
    ARETDYPAGE ELSESGQVDK ASLCGSMTSN SSAEMDSLLG GITVVGCSTE 850
    GLTGAATSPS TNGASPVIEK PPEMETENSE VDENIPTAEE ATEATEGNAG 900
    STEDTVDISQ PGVYTEHVFT DPLGVQIPED LSPVFQSSND SDVYKDQISV 950
    LPNEQDLARE EAQKMSSLLP TMWLGAQNGC LYVHSSVAQW RKCLHSIKLK 1000
    DSILSIVHVK GIVLVALADG TLAIFHRGVD GQWDLSNYHL LDLGRPHHSI 1050
    RCMTVVHDKV WCGYRNKIYV VQPKAMKIEK SFDAHPRKES QVRQLAWVGD 1100
    GVWVSIRLDS TLRLYHAHTY QHLQDVDIEP YVSKMLGTGK LGFSFVRITA 1150
    LMVSCNRLWV GTGNGVIISI PLTETNKTSG TPGNRPGSVI RVYGDENSDK 1200
    VTPGTFIPYC SMAHAQLCFH GHRDAVKFFV AVPGQVISPQ SSSGGADLTA 1250
    DKAGSSAQEP SSQTPLKSML VISGGEGYID FRMGDEGGES ELLGEDLPLE 1300
    PSVTKAERSH LIVWQVMCGN E 1321
    Length:1,321
    Mass (Da):146,219
    Last modified:May 2, 2006 - v2
    Checksum:i93A6E97A62E0E92C
    GO
    Isoform 2 (identifier: Q58A65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-261: Missing.

    Show »
    Length:1,307
    Mass (Da):144,704
    Checksum:i8C99195A5AFFC7BF
    GO
    Isoform 3 (identifier: Q58A65-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-143: Missing.
         144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
         248-261: Missing.
         405-405: G → GEYSG

    Note: No experimental confirmation available.

    Show »
    Length:1,168
    Mass (Da):127,680
    Checksum:i34B7E6B2D81B7DF9
    GO
    Isoform 4 (identifier: Q58A65-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-143: Missing.
         144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
         248-261: Missing.
         1175-1175: T → TVILHQGRLLGLRA

    Note: No experimental confirmation available.

    Show »
    Length:1,177
    Mass (Da):128,672
    Checksum:i730D991D29C5A74B
    GO
    Isoform 5 (identifier: Q58A65-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
         248-261: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,307
    Mass (Da):143,835
    Checksum:iF186D445467EE5B6
    GO
    Isoform 6 (identifier: Q58A65-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-165: Missing.
         248-261: Missing.

    Show »
    Length:1,142
    Mass (Da):125,350
    Checksum:i16184E1CE2BF26A1
    GO

    Sequence cautioni

    The sequence BAD32239.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI35376.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti241 – 2411R → C in AAN61564. (PubMed:12391307)Curated
    Sequence conflicti453 – 4531E → A in AAN61564. (PubMed:12391307)Curated
    Sequence conflicti468 – 4681E → G in BAE27980. (PubMed:16141072)Curated
    Sequence conflicti705 – 7051S → T in BAD93176. 1 PublicationCurated
    Sequence conflicti1114 – 11141L → P in BAE27907. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 165165Missing in isoform 6. 1 PublicationVSP_018225Add
    BLAST
    Alternative sequencei1 – 143143Missing in isoform 3 and isoform 4. 2 PublicationsVSP_018226Add
    BLAST
    Alternative sequencei144 – 19653RLEER…AHSRI → MNPGCMLLFVFGFVGGAVVI NSAILVSLSVLLLVHFSIST GVPALTQNLPRIL in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_018227Add
    BLAST
    Alternative sequencei248 – 26114Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 5 PublicationsVSP_018228Add
    BLAST
    Alternative sequencei405 – 4051G → GEYSG in isoform 3. 1 PublicationVSP_018229
    Alternative sequencei1175 – 11751T → TVILHQGRLLGLRA in isoform 4. 1 PublicationVSP_018230

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF327451 mRNA. Translation: AAN61564.1.
    AY823270 mRNA. Translation: AAX19462.1.
    AB047782 mRNA. Translation: BAD93176.1.
    AK172961 mRNA. Translation: BAD32239.1. Different initiation.
    AK147431 mRNA. Translation: BAE27907.1.
    AK147537 mRNA. Translation: BAE27980.1.
    AL662838 Genomic DNA. Translation: CAI35367.1.
    AL662838 Genomic DNA. Translation: CAI35375.1.
    AL662838 Genomic DNA. Translation: CAI35376.1. Sequence problems.
    BC060100 mRNA. Translation: AAH60100.1.
    BC094670 mRNA. Translation: AAH94670.1.
    CCDSiCCDS25248.1. [Q58A65-2]
    CCDS56797.1. [Q58A65-3]
    RefSeqiNP_001020599.1. NM_001025428.1.
    NP_001020600.1. NM_001025429.1. [Q58A65-3]
    NP_001020601.1. NM_001025430.1.
    NP_001186132.1. NM_001199203.1.
    NP_001186133.1. NM_001199204.1.
    NP_001186134.1. NM_001199205.1. [Q58A65-4]
    NP_081845.2. NM_027569.2. [Q58A65-2]
    XP_006534282.1. XM_006534219.1. [Q58A65-6]
    UniGeneiMm.260737.

    Genome annotation databases

    EnsembliENSMUST00000041956; ENSMUSP00000042271; ENSMUSG00000020859. [Q58A65-2]
    ENSMUST00000075695; ENSMUSP00000075115; ENSMUSG00000020859. [Q58A65-3]
    ENSMUST00000103168; ENSMUSP00000099457; ENSMUSG00000020859.
    GeneIDi70834.
    KEGGimmu:70834.
    UCSCiuc007kxx.1. mouse. [Q58A65-2]
    uc007kxy.1. mouse. [Q58A65-1]
    uc007kxz.1. mouse. [Q58A65-6]
    uc007kya.1. mouse. [Q58A65-3]
    uc007kyc.1. mouse. [Q58A65-5]
    uc007kyd.1. mouse. [Q58A65-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF327451 mRNA. Translation: AAN61564.1 .
    AY823270 mRNA. Translation: AAX19462.1 .
    AB047782 mRNA. Translation: BAD93176.1 .
    AK172961 mRNA. Translation: BAD32239.1 . Different initiation.
    AK147431 mRNA. Translation: BAE27907.1 .
    AK147537 mRNA. Translation: BAE27980.1 .
    AL662838 Genomic DNA. Translation: CAI35367.1 .
    AL662838 Genomic DNA. Translation: CAI35375.1 .
    AL662838 Genomic DNA. Translation: CAI35376.1 . Sequence problems.
    BC060100 mRNA. Translation: AAH60100.1 .
    BC094670 mRNA. Translation: AAH94670.1 .
    CCDSi CCDS25248.1. [Q58A65-2 ]
    CCDS56797.1. [Q58A65-3 ]
    RefSeqi NP_001020599.1. NM_001025428.1.
    NP_001020600.1. NM_001025429.1. [Q58A65-3 ]
    NP_001020601.1. NM_001025430.1.
    NP_001186132.1. NM_001199203.1.
    NP_001186133.1. NM_001199204.1.
    NP_001186134.1. NM_001199205.1. [Q58A65-4 ]
    NP_081845.2. NM_027569.2. [Q58A65-2 ]
    XP_006534282.1. XM_006534219.1. [Q58A65-6 ]
    UniGenei Mm.260737.

    3D structure databases

    ProteinModelPortali Q58A65.
    SMRi Q58A65. Positions 406-466, 1001-1026.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214283. 5 interactions.
    IntActi Q58A65. 3 interactions.
    MINTi MINT-1351345.
    STRINGi 10090.ENSMUSP00000099458.

    PTM databases

    PhosphoSitei Q58A65.

    Proteomic databases

    MaxQBi Q58A65.
    PaxDbi Q58A65.
    PRIDEi Q58A65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041956 ; ENSMUSP00000042271 ; ENSMUSG00000020859 . [Q58A65-2 ]
    ENSMUST00000075695 ; ENSMUSP00000075115 ; ENSMUSG00000020859 . [Q58A65-3 ]
    ENSMUST00000103168 ; ENSMUSP00000099457 ; ENSMUSG00000020859 .
    GeneIDi 70834.
    KEGGi mmu:70834.
    UCSCi uc007kxx.1. mouse. [Q58A65-2 ]
    uc007kxy.1. mouse. [Q58A65-1 ]
    uc007kxz.1. mouse. [Q58A65-6 ]
    uc007kya.1. mouse. [Q58A65-3 ]
    uc007kyc.1. mouse. [Q58A65-5 ]
    uc007kyd.1. mouse. [Q58A65-4 ]

    Organism-specific databases

    CTDi 9043.
    MGIi MGI:1918084. Spag9.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG270333.
    GeneTreei ENSGT00670000097546.
    HOVERGENi HBG024110.
    InParanoidi Q58A65.
    OMAi GSDQLES.
    OrthoDBi EOG7GXP9P.
    PhylomeDBi Q58A65.
    TreeFami TF313096.

    Miscellaneous databases

    ChiTaRSi SPAG9. mouse.
    NextBioi 332372.
    PROi Q58A65.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q58A65.
    Bgeei Q58A65.
    CleanExi MM_SPAG9.
    Genevestigatori Q58A65.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR019143. JNK/Rab-associated_protein-1_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF09744. Jnk-SapK_ap_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors."
      Lee C.M., Onesime D., Reddy C.D., Dhanasekaran N., Reddy E.P.
      Proc. Natl. Acad. Sci. U.S.A. 99:14189-14194(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH MAX; MAPK8; MAPK14; MAP3K3; MYC AND MAP2K4, SUBCELLULAR LOCATION.
    2. "Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways."
      Kelkar N., Standen C.L., Davis R.J.
      Mol. Cell. Biol. 25:2733-2743(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), FUNCTION, INTERACTION WITH KNS2 AND MAPK8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "JSAP2, a novel member of the JSAP1 JNK scaffold protein family."
      Takamatsu N., Tochigi M., Ito M., Odama Y., Xu P., Nakabeppu Y., Yoshioka K., Shiba T.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6J.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Strain: C57BL/6.
      Tissue: Brain and Olfactory epithelium.
    8. "JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain."
      Nguyen Q., Lee C.M., Le A., Reddy E.P.
      J. Biol. Chem. 280:30185-30191(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KNS2, INDUCTION.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217 AND THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiJIP4_MOUSE
    AccessioniPrimary (citable) accession number: Q58A65
    Secondary accession number(s): Q3UH77
    , Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3