Q58A45 (PAN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PAB-dependent poly(A)-specific ribonuclease subunit 3
Short name=hPan3

Gene names

Name:

PAN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	887 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity. Ref.5
Subunit structure	Interacts with PAN2 to form the Pan nuclease complex. Mediates the interaction of the Pan nuclease complex with polyadenylate-binding protein. Ref.5
Subcellular location	Cytoplasm Ref.5.
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Contains 1 C3H1-type zinc finger. Contains 1 protein kinase domain.
Sequence caution	The sequence AAI28180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence ABK41888.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAC03632.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI12449.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12450.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI14848.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM20921.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Nonsense-mediated mRNA decay
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA Inferred from electronic annotation. Source: Compara nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from electronic annotation. Source: UniProtKB-KW nuclear-transcribed mRNA poly(A) tail shortening Traceable author statement. Source: Reactome positive regulation of cytoplasmic mRNA processing body assembly Inferred from electronic annotation. Source: Compara protein targeting Inferred from electronic annotation. Source: Compara
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasmic mRNA processing body Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q58A45-1)

Also known as: Pan3b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q58A45-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-333: P → MKLTDSTKGWIVWAALDSSMR

Isoform 3 (identifier: Q58A45-3)

The sequence of this isoform differs from the canonical sequence as follows:
     231-284: Missing.

Isoform 4 (identifier: Q58A45-4)

The sequence of this isoform differs from the canonical sequence as follows:
     684-687: QADL → VSKN
     688-887: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 887	887	PAB-dependent poly(A)-specific ribonuclease subunit 3		PRO_0000280525
Regions
	Domain	492 – 754	263	Protein kinase
	Zinc finger	43 – 71	29	C3H1-type
	Region	1 – 491	491	Interaction with polyadenylate-binding protein
	Region	492 – 887	396	Interaction with PAN2
Natural variations
	Alternative sequence	1 – 332	332	Missing in isoform 2.		VSP_023753
	Alternative sequence	231 – 284	54	Missing in isoform 3.		VSP_023754
	Alternative sequence	333	1	P → MKLTDSTKGWIVWAALDSSM R in isoform 2.		VSP_023755
	Alternative sequence	684 – 687	4	QADL → VSKN in isoform 4.		VSP_041648
	Alternative sequence	688 – 887	200	Missing in isoform 4.		VSP_041649
Experimental info
	Sequence conflict	229	1	R → Q in BAD02262. Ref.5
	Sequence conflict	569	1	Y → H in AAI28181. Ref.4
	Sequence conflict	793	1	R → G in BAC03632. Ref.1
	Sequence conflict	856	1	D → G in BAD02262. Ref.5
	Sequence conflict	856	1	D → G in BAD93184. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Pan3b) [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 4883F859D2A642D2	FASTA	887	95,613
	10 20 30 40 50 60 MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY 70 80 90 100 110 120 GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG 130 140 150 160 170 180 DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY 190 200 210 220 230 240 PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK PRKYRLGMLE 250 260 270 280 290 300 ERLVPMGSKA RKAKNPIGCL ADRCKSGVPI NMVWWNRVTE NNLQTPNPTA SEFIPKGGST 310 320 330 340 350 360 SRLSNVSQSN MSAFSQVFSH PSMGSPATAG LAPGMSLSAG SSPLHSPKIT PHTSPAPRRR 370 380 390 400 410 420 SHTPNPASYM VPSSASTSVN NPVSQTPSSG QVIQKETVGG TTYFYTDTTP APLTGMVFPN 430 440 450 460 470 480 YHIYPPTAPH VAYMQPKANA PSFFMADELR QELINRHLIT MAQIDQADMP AVPTEVDSYH 490 500 510 520 530 540 SLFPLEPLPP PNRIQKSSNF GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW 550 560 570 580 590 600 KKIQHSNIVT LREVFTTKAF AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH 610 620 630 640 650 660 EGPLPRQHAG LLPESLIWAY IVQLSSALRT IHTAGLACRV MDPTKILITG KTRLRVNCVG 670 680 690 700 710 720 VFDVLTFDNS QNNNPLALMA QYQQADLISL GKVVLALACN SLAGIQRENL QKAMELVTIN 730 740 750 760 770 780 YSSDLKNLIL YLLTDQNRMR SVNDIMPMIG ARFYTQLDAA QMRNDVIEED LAKEVQNGRL 790 800 810 820 830 840 FRLLAKLGTI NERPEFQKDP TWSETGDRYL LKLFRDHLFH QVTEAGAPWI DLSHIISCLN 850 860 870 880 KLDAGVPEKI SLISRDEKSV LVVTYSDLKR CFENTFQELI AAANGQL
	Isoform 2 [UniParc]. Checksum: 8FF7B393A072FD8D	FASTA	575	64,465
	10 20 30 40 50 60 MKLTDSTKGW IVWAALDSSM RGMSLSAGSS PLHSPKITPH TSPAPRRRSH TPNPASYMVP 70 80 90 100 110 120 SSASTSVNNP VSQTPSSGQV IQKETVGGTT YFYTDTTPAP LTGMVFPNYH IYPPTAPHVA 130 140 150 160 170 180 YMQPKANAPS FFMADELRQE LINRHLITMA QIDQADMPAV PTEVDSYHSL FPLEPLPPPN 190 200 210 220 230 240 RIQKSSNFGY ITSCYKAVNS KDDLPYCLRR IHGFRLVNTK CMVLVDMWKK IQHSNIVTLR 250 260 270 280 290 300 EVFTTKAFAE PSLVFAYDFH AGGETMMSRH FNDPNADAYF TKRKWGQHEG PLPRQHAGLL 310 320 330 340 350 360 PESLIWAYIV QLSSALRTIH TAGLACRVMD PTKILITGKT RLRVNCVGVF DVLTFDNSQN 370 380 390 400 410 420 NNPLALMAQY QQADLISLGK VVLALACNSL AGIQRENLQK AMELVTINYS SDLKNLILYL 430 440 450 460 470 480 LTDQNRMRSV NDIMPMIGAR FYTQLDAAQM RNDVIEEDLA KEVQNGRLFR LLAKLGTINE 490 500 510 520 530 540 RPEFQKDPTW SETGDRYLLK LFRDHLFHQV TEAGAPWIDL SHIISCLNKL DAGVPEKISL 550 560 570 ISRDEKSVLV VTYSDLKRCF ENTFQELIAA ANGQL
	Isoform 3 [UniParc]. Checksum: 06EAD23E1B205A4F	FASTA	833	89,405
	10 20 30 40 50 60 MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY 70 80 90 100 110 120 GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG 130 140 150 160 170 180 DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY 190 200 210 220 230 240 PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK TPNPTASEFI 250 260 270 280 290 300 PKGGSTSRLS NVSQSNMSAF SQVFSHPSMG SPATAGLAPG MSLSAGSSPL HSPKITPHTS 310 320 330 340 350 360 PAPRRRSHTP NPASYMVPSS ASTSVNNPVS QTPSSGQVIQ KETVGGTTYF YTDTTPAPLT 370 380 390 400 410 420 GMVFPNYHIY PPTAPHVAYM QPKANAPSFF MADELRQELI NRHLITMAQI DQADMPAVPT 430 440 450 460 470 480 EVDSYHSLFP LEPLPPPNRI QKSSNFGYIT SCYKAVNSKD DLPYCLRRIH GFRLVNTKCM 490 500 510 520 530 540 VLVDMWKKIQ HSNIVTLREV FTTKAFAEPS LVFAYDFHAG GETMMSRHFN DPNADAYFTK 550 560 570 580 590 600 RKWGQHEGPL PRQHAGLLPE SLIWAYIVQL SSALRTIHTA GLACRVMDPT KILITGKTRL 610 620 630 640 650 660 RVNCVGVFDV LTFDNSQNNN PLALMAQYQQ ADLISLGKVV LALACNSLAG IQRENLQKAM 670 680 690 700 710 720 ELVTINYSSD LKNLILYLLT DQNRMRSVND IMPMIGARFY TQLDAAQMRN DVIEEDLAKE 730 740 750 760 770 780 VQNGRLFRLL AKLGTINERP EFQKDPTWSE TGDRYLLKLF RDHLFHQVTE AGAPWIDLSH 790 800 810 820 830 IISCLNKLDA GVPEKISLIS RDEKSVLVVT YSDLKRCFEN TFQELIAAAN GQL
	Isoform 4 [UniParc]. Checksum: C3AFEB0807CE9F3B	FASTA	687	72,933
	10 20 30 40 50 60 MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY 70 80 90 100 110 120 GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG 130 140 150 160 170 180 DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY 190 200 210 220 230 240 PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK PRKYRLGMLE 250 260 270 280 290 300 ERLVPMGSKA RKAKNPIGCL ADRCKSGVPI NMVWWNRVTE NNLQTPNPTA SEFIPKGGST 310 320 330 340 350 360 SRLSNVSQSN MSAFSQVFSH PSMGSPATAG LAPGMSLSAG SSPLHSPKIT PHTSPAPRRR 370 380 390 400 410 420 SHTPNPASYM VPSSASTSVN NPVSQTPSSG QVIQKETVGG TTYFYTDTTP APLTGMVFPN 430 440 450 460 470 480 YHIYPPTAPH VAYMQPKANA PSFFMADELR QELINRHLIT MAQIDQADMP AVPTEVDSYH 490 500 510 520 530 540 SLFPLEPLPP PNRIQKSSNF GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW 550 560 570 580 590 600 KKIQHSNIVT LREVFTTKAF AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH 610 620 630 640 650 660 EGPLPRQHAG LLPESLIWAY IVQLSSALRT IHTAGLACRV MDPTKILITG KTRLRVNCVG 670 680 VFDVLTFDNS QNNNPLALMA QYQVSKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-887 (ISOFORMS 1/2/3). Tissue: Skin fibroblast.
[2]	SeattleSNPs variation discovery resource Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-887 (ISOFORM 1). Tissue: Uterus.
[5]	"Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein." Uchida N., Hoshino S., Katada T. J. Biol. Chem. 279:1383-1391(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 147-887 (ISOFORMS 1 AND 3), FUNCTION, INTERACTION WITH PAN2 AND POLYADENYLATE-BINDING PROTEIN, SUBCELLULAR LOCATION. Tissue: Cervix carcinoma.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-887 (ISOFORMS 1/2/3). Tissue: Adrenal gland.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091307 mRNA. Translation: BAC03632.1. Different initiation. AK296435 mRNA. Translation: BAH12353.1. EF088216 Genomic DNA. Translation: ABK41888.1. Sequence problems. AL356915, AL138712 Genomic DNA. Translation: CAI12449.2. Sequence problems. AL356915, AL138712 Genomic DNA. Translation: CAI12450.2. Sequence problems. AL138712, AL356915 Genomic DNA. Translation: CAI14848.1. Sequence problems. AL138712, AL356915 Genomic DNA. Translation: CAM20921.1. Sequence problems. BC024318 mRNA. Translation: AAH24318.1. BC128179 mRNA. Translation: AAI28180.1. Different initiation. BC128180 mRNA. Translation: AAI28181.1. AB107584 mRNA. Translation: BAD02262.1. AB109552 mRNA. Translation: BAD93184.1. BX647740 mRNA. Translation: CAI45987.2.
IPI	IPI00513919. IPI00829672. IPI00954802. IPI01022195.
RefSeq	NP_787050.6. NM_175854.7.
UniGene	Hs.645015.
3D structure databases
ProteinModelPortal	Q58A45.
SMR	Q58A45. Positions 493-650.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q58A45. 1 interaction.
PTM databases
PhosphoSite	Q58A45.
Polymorphism databases
DMDM	134034989.
Proteomic databases
PaxDb	Q58A45.
PRIDE	Q58A45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282391; ENSP00000282391; ENSG00000152520. ENST00000380958; ENSP00000370345; ENSG00000152520. ENST00000399613; ENSP00000382522; ENSG00000152520.
GeneID	255967.
KEGG	hsa:255967.
UCSC	uc001urx.3. human. uc001ury.3. human. uc001urz.3. human. uc010tdo.1. human.
Organism-specific databases
CTD	255967.
GeneCards	GC13P028713.
H-InvDB	HIX0011200.
HGNC	HGNC:29991. PAN3.
HPA	HPA028817.
neXtProt	NX_Q58A45.
PharmGKB	PA144596398.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260889.
HOVERGEN	HBG058849.
InParanoid	Q58A45.
KO	K12572.
OMA	YYAKDKT.
OrthoDB	EOG4K9BBK.
Enzyme and pathway databases
Reactome	REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q58A45.
Bgee	Q58A45.
CleanEx	HS_PAN3.
Genevestigator	Q58A45.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR000571. Znf_CCCH. [Graphical view]
SMART	SM00356. ZnF_C3H1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAN3. human.
GenomeRNAi	255967.
NextBio	92689.

Entry information

Entry name

PAN3_HUMAN

Accession

Primary (citable) accession number: Q58A45
Secondary accession number(s): A0N0X1 , A1A4Y8, A1A4Y9, B1ALF1, B7Z3W7, Q0D2P2, Q5HYG6, Q5T515, Q5T516, Q5TBA0, Q76E13, Q8NBA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.