Q58A44 (PCOTH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PCOTH

Alternative name(s):
Prostate collagen triple helix protein

Gene names

Name:

PCOTH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway. Ref.2
Subcellular location	Cytoplasm Ref.2.
Tissue specificity	Expressed in prostate and testis. Weakly or not expressed in other tissues. Overexpressed in prostate cancers. Ref.2

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Protein PCOTH		PRO_0000337141
Regions
	Compositional bias	35 – 107	73	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q58A44 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: B738A5D9E95AF097	FASTA	107	10,968
	10 20 30 40 50 60 MWILSNLMGT SEEGNLLSTV SPTVKALFGK TRVSPIFPFS PRSPFQPLIP RTPGSPWGPV 70 80 90 100 GPASPLGPGF PIGPMGPGKP VGPKGPMLPL GPSGPVGPTS PLFPFCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostatic carcinoma.
[2]	"PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET." Anazawa Y., Nakagawa H., Furihara M., Ashida S., Tamura K., Yoshioka H., Shuin T., Fujioka T., Katagiri T., Nakamura Y. Cancer Res. 65:4578-4586(2005) [PubMed: 15930275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-107, POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Prostatic carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC015452 mRNA. No translation available. AB113650 mRNA. Translation: BAD93185.1.
IPI	IPI00555685.
RefSeq	NP_001014442.2. NM_001014442.2.
UniGene	Hs.642624.
3D structure databases
ProteinModelPortal	Q58A44.
ModBase	Search...
Protein-protein interaction databases
STRING	Q58A44.
Polymorphism databases
DMDM	189029598.
Proteomic databases
PRIDE	Q58A44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422229; ENSP00000396192; ENSG00000205850.
GeneID	542767.
KEGG	hsa:542767.
UCSC	uc001uoy.1. human.
Organism-specific databases
CTD	542767.
GeneCards	GC13M024896. GC13P024464.
H-InvDB	HIX0037328.
HPA	HPA046221.
neXtProt	NX_Q58A44.
Phylogenomic databases
eggNOG	prNOG20494.
GeneTree	ENSGT00510000049756.
InParanoid	Q58A44.
Gene expression databases
Genevestigator	Q58A44.
Family and domain databases
ProtoNet	Search...
Other
NextBio	112120.

Entry information

Entry name

PCOTH_HUMAN

Accession

Primary (citable) accession number: Q58A44

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.