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Protein

Prostate collagen triple helix protein

Gene

C1QTNF9B-AS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate collagen triple helix protein
Alternative name(s):
C1QTNF9B antisense RNA 1
C1QTNF9B antisense gene protein 1
Gene namesi
Name:C1QTNF9B-AS1
Synonyms:PCOTH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39839. C1QTNF9B-AS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPCOTH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Prostate collagen triple helix proteinPRO_0000337141Add
BLAST

Proteomic databases

PaxDbiQ58A44.
PRIDEiQ58A44.

Expressioni

Tissue specificityi

Expressed in prostate and testis. Weakly or not expressed in other tissues. Overexpressed in prostate cancers.1 Publication

Organism-specific databases

HPAiHPA046221.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-10243387,EBI-348380

Protein-protein interaction databases

BioGridi139079. 1 interaction.
IntActiQ58A44. 1 interaction.
STRINGi9606.ENSP00000396192.

Structurei

3D structure databases

ProteinModelPortaliQ58A44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 10773Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410JCC7. Eukaryota.
ENOG41114ZV. LUCA.
HOGENOMiHOG000169380.
InParanoidiQ58A44.
PhylomeDBiQ58A44.

Sequencei

Sequence statusi: Complete.

Q58A44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWILSNLMGT SEEGNLLSTV SPTVKALFGK TRVSPIFPFS PRSPFQPLIP
60 70 80 90 100
RTPGSPWGPV GPASPLGPGF PIGPMGPGKP VGPKGPMLPL GPSGPVGPTS

PLFPFCP
Length:107
Mass (Da):10,968
Last modified:May 20, 2008 - v2
Checksum:iB738A5D9E95AF097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015452 mRNA. No translation available.
AB113650 mRNA. Translation: BAD93185.1.
RefSeqiNP_001014442.2. NM_001014442.2.
UniGeneiHs.642624.

Genome annotation databases

GeneIDi542767.
KEGGihsa:542767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015452 mRNA. No translation available.
AB113650 mRNA. Translation: BAD93185.1.
RefSeqiNP_001014442.2. NM_001014442.2.
UniGeneiHs.642624.

3D structure databases

ProteinModelPortaliQ58A44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139079. 1 interaction.
IntActiQ58A44. 1 interaction.
STRINGi9606.ENSP00000396192.

Polymorphism and mutation databases

BioMutaiPCOTH.

Proteomic databases

PaxDbiQ58A44.
PRIDEiQ58A44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542767.
KEGGihsa:542767.

Organism-specific databases

CTDi542767.
GeneCardsiC1QTNF9B-AS1.
HGNCiHGNC:39839. C1QTNF9B-AS1.
HPAiHPA046221.
neXtProtiNX_Q58A44.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCC7. Eukaryota.
ENOG41114ZV. LUCA.
HOGENOMiHOG000169380.
InParanoidiQ58A44.
PhylomeDBiQ58A44.

Miscellaneous databases

GenomeRNAii542767.
NextBioi112120.
PROiQ58A44.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostatic carcinoma.
  2. "PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET."
    Anazawa Y., Nakagawa H., Furihara M., Ashida S., Tamura K., Yoshioka H., Shuin T., Fujioka T., Katagiri T., Nakamura Y.
    Cancer Res. 65:4578-4586(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-107, POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostatic carcinoma.

Entry informationi

Entry nameiPCOTH_HUMAN
AccessioniPrimary (citable) accession number: Q58A44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 16, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.