Reviewed, UniProtKB/Swiss-Prot Q58A44 (PCOTH_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein PCOTH
Alternative name(s):
    Prostate collagen triple helix protein

Gene names

Name:

PCOTH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in prostate and testis. Weakly or not expressed in other tissues. Overexpressed in prostate cancers.

Ontologies

Keywords
Cellular component	Cytoplasm
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Protein PCOTH		PRO_0000337141
Regions
	Compositional bias	35 – 107	73	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q58A44-1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: B738A5D9E95AF097	FASTA	107	10,968
	10 20 30 40 50 60 MWILSNLMGT SEEGNLLSTV SPTVKALFGK TRVSPIFPFS PRSPFQPLIP RTPGSPWGPV 70 80 90 100 GPASPLGPGF PIGPMGPGKP VGPKGPMLPL GPSGPVGPTS PLFPFCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostatic carcinoma.
[2]	"PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET." Anazawa Y., Nakagawa H., Furihara M., Ashida S., Tamura K., Yoshioka H., Shuin T., Fujioka T., Katagiri T., Nakamura Y. Cancer Res. 65:4578-4586(2005) [PubMed: 15930275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-107, POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Prostatic carcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC015452 mRNA. No translation available. AB113650 mRNA. Translation: BAD93185.1.
RefSeq	NP_001014442.2.
UniGene	Hs.642624
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000205861. Homo sapiens. [Contig view]
GeneID	542767.
KEGG	hsa:542767.
Organism-specific databases
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q58A44.
HOVERGEN	Q58A44.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	112120.

Entry information

Entry name

PCOTH_HUMAN

Accession

Primary (citable) accession number: Q58A44

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	November 4, 2008
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)