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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: D-ribose 5-phosphate biosynthesis

This protein is involved in the pathway D-ribose 5-phosphate biosynthesis, which is part of Carbohydrate biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway D-ribose 5-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Proton acceptor1 Publication1
Binding sitei124SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi5.3.1.6. 3260.
UniPathwayiUPA00293.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:MJ1603
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585101 – 226Ribose-5-phosphate isomerase AAdd BLAST226

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1603.

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Helixi15 – 17Combined sources3
Beta strandi23 – 26Combined sources4
Helixi30 – 46Combined sources17
Beta strandi51 – 56Combined sources6
Helixi57 – 65Combined sources9
Turni73 – 75Combined sources3
Beta strandi79 – 83Combined sources5
Beta strandi86 – 89Combined sources4
Turni90 – 92Combined sources3
Helixi103 – 112Combined sources10
Beta strandi113 – 121Combined sources9
Helixi122 – 124Combined sources3
Beta strandi125 – 128Combined sources4
Beta strandi131 – 133Combined sources3
Beta strandi135 – 139Combined sources5
Helixi141 – 143Combined sources3
Helixi144 – 153Combined sources10
Beta strandi157 – 160Combined sources4
Beta strandi164 – 169Combined sources6
Beta strandi177 – 182Combined sources6
Helixi188 – 196Combined sources9
Beta strandi201 – 207Combined sources7
Beta strandi211 – 217Combined sources7
Beta strandi220 – 224Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IXQX-ray1.78A/B/C/D1-226[»]
ProteinModelPortaliQ58998.
SMRiQ58998.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58998.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate binding4
Regioni83 – 86Substrate bindingCurated4
Regioni97 – 100Substrate bindingCurated4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01122. Archaea.
COG0120. LUCA.
InParanoidiQ58998.
KOiK01807.
OMAiIFNHQNT.
PhylomeDBiQ58998.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEDLKLKV AKEAVKLVKD GMVIGLGTGS TAALFIRELG NRIREEELTV
60 70 80 90 100
FGIPTSFEAK MLAMQYEIPL VTLDEYDVDI AFDGADEVEE TTLFLIKGGG
110 120 130 140 150
GCHTQEKIVD YNANEFVVLV DESKLVKKLG EKFPIPVEVI PSAYRVVIRA
160 170 180 190 200
LSEMGGEAVI RLGDRKRGPV ITDNGNMIID VFMNIDDAIE LEKEINNIPG
210 220
VVENGIFTKV DKVLVGTKKG VKTLKK
Length:226
Mass (Da):24,830
Last modified:November 1, 1996 - v1
Checksum:iC0F1C2C1A5499123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99623.1.
PIRiB64500.
RefSeqiWP_010871128.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99623; AAB99623; MJ_1603.
GeneIDi1452512.
KEGGimja:MJ_1603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99623.1.
PIRiB64500.
RefSeqiWP_010871128.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IXQX-ray1.78A/B/C/D1-226[»]
ProteinModelPortaliQ58998.
SMRiQ58998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99623; AAB99623; MJ_1603.
GeneIDi1452512.
KEGGimja:MJ_1603.

Phylogenomic databases

eggNOGiarCOG01122. Archaea.
COG0120. LUCA.
InParanoidiQ58998.
KOiK01807.
OMAiIFNHQNT.
PhylomeDBiQ58998.

Enzyme and pathway databases

UniPathwayiUPA00293.
BRENDAi5.3.1.6. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58998.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_METJA
AccessioniPrimary (citable) accession number: Q58998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.