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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: D-ribose 5-phosphate biosynthesis

This protein is involved in the pathway D-ribose 5-phosphate biosynthesis, which is part of Carbohydrate biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway D-ribose 5-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton acceptor1 Publication
Binding sitei124 – 1241SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi5.3.1.6. 3260.
UniPathwayiUPA00293.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:MJ1603
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Ribose-5-phosphate isomerase APRO_0000158510Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1603.

Structurei

Secondary structure

1
226
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411Combined sources
Helixi15 – 173Combined sources
Beta strandi23 – 264Combined sources
Helixi30 – 4617Combined sources
Beta strandi51 – 566Combined sources
Helixi57 – 659Combined sources
Turni73 – 753Combined sources
Beta strandi79 – 835Combined sources
Beta strandi86 – 894Combined sources
Turni90 – 923Combined sources
Helixi103 – 11210Combined sources
Beta strandi113 – 1219Combined sources
Helixi122 – 1243Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi135 – 1395Combined sources
Helixi141 – 1433Combined sources
Helixi144 – 15310Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi164 – 1696Combined sources
Beta strandi177 – 1826Combined sources
Helixi188 – 1969Combined sources
Beta strandi201 – 2077Combined sources
Beta strandi211 – 2177Combined sources
Beta strandi220 – 2245Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IXQX-ray1.78A/B/C/D1-226[»]
ProteinModelPortaliQ58998.
SMRiQ58998. Positions 2-226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58998.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 314Substrate binding
Regioni83 – 864Substrate bindingCurated
Regioni97 – 1004Substrate bindingCurated

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01122. Archaea.
COG0120. LUCA.
InParanoidiQ58998.
KOiK01807.
OMAiTINNPYA.
PhylomeDBiQ58998.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEDLKLKV AKEAVKLVKD GMVIGLGTGS TAALFIRELG NRIREEELTV
60 70 80 90 100
FGIPTSFEAK MLAMQYEIPL VTLDEYDVDI AFDGADEVEE TTLFLIKGGG
110 120 130 140 150
GCHTQEKIVD YNANEFVVLV DESKLVKKLG EKFPIPVEVI PSAYRVVIRA
160 170 180 190 200
LSEMGGEAVI RLGDRKRGPV ITDNGNMIID VFMNIDDAIE LEKEINNIPG
210 220
VVENGIFTKV DKVLVGTKKG VKTLKK
Length:226
Mass (Da):24,830
Last modified:November 1, 1996 - v1
Checksum:iC0F1C2C1A5499123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99623.1.
PIRiB64500.

Genome annotation databases

EnsemblBacteriaiAAB99623; AAB99623; MJ_1603.
KEGGimja:MJ_1603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99623.1.
PIRiB64500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IXQX-ray1.78A/B/C/D1-226[»]
ProteinModelPortaliQ58998.
SMRiQ58998. Positions 2-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99623; AAB99623; MJ_1603.
KEGGimja:MJ_1603.

Phylogenomic databases

eggNOGiarCOG01122. Archaea.
COG0120. LUCA.
InParanoidiQ58998.
KOiK01807.
OMAiTINNPYA.
PhylomeDBiQ58998.

Enzyme and pathway databases

UniPathwayiUPA00293.
BRENDAi5.3.1.6. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58998.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway."
    Grochowski L.L., Xu H., White R.H.
    J. Bacteriol. 187:7382-7389(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATHWAY.
  3. "The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603)."
    Strange R.W., Antonyuk S.V., Ellis M.J., Bessho Y., Kuramitsu S., Yokoyama S., Hasnain S.S.
    Acta Crystallogr. F 65:1214-1217(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOGS, ACTIVE SITE, SUBUNIT.

Entry informationi

Entry nameiRPIA_METJA
AccessioniPrimary (citable) accession number: Q58998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.