Reviewed, UniProtKB/Swiss-Prot Q58997 (DHOM_METJA)

Names and origin

Protein names

Recommended name:
    Homoserine dehydrogenase
      Short name=HDH
    EC=1.1.1.3

Gene names

Name:	hom
Ordered Locus Names:	MJ1602

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Sequence similarities	Belongs to the homoserine dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Homoserine dehydrogenase		PRO_0000066705
Regions
	Nucleotide binding	6 – 13	8	NADP By similarity
Sites
	Active site	223	1	Proton donor Potential
	Binding site	94	1	NADP By similarity
	Binding site	123	1	NADP By similarity
	Binding site	208	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58997-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EDAEFA1998439B48	FASTA	336	36,462
	10 20 30 40 50 60 MDIIIVGFGA IGKGIAKVLY DKKDYLKKNY EEFKVVAITD SSGAAIDEDG LDLLKAIEVK 70 80 90 100 110 120 EKTGKIKNYP EKGREMSSID VIKEVDADVV VEVTPSNLET GDPAKTHILE SFKNKKHVVT 130 140 150 160 170 180 ANKGPLALCY KELIEEAKKH GVIFRHEASV GGAMPIINLA KETLAGNEIL SIRGILNGTT 190 200 210 220 230 240 NYILTKMEKE GLDFETALKE AKELGIAETD PTQDIEGLDT AAKIVILANS IMGMNKTIKD 250 260 270 280 290 300 VKVKGISRIT PEALFLANKR GYTIKLIGQI KDGYLIVEPM LVPIDSPLNV KGTLNVAMFE 310 320 330 TDLAKEVVVV GRGAGPIETA SAILSDLIHI YNSTKK

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99622.1.
PIR	A64500.
RefSeq	NP_248612.1.
3D structure databases
SMR	Q58997. Positions 1-334.
ModBase	Search...
Genome annotation databases
GeneID	1452511.
GenomeReviews	Gene locus MJ1602 in contig L77117_GR.
KEGG	mja:MJ1602.
NMPDR	fig|243232.1.peg.1649.
TIGR	MJ1602.
Phylogenomic databases
HOGENOM	HBG527379.
OMA	GRIETAF.
Enzyme and pathway databases
BRENDA	1.1.1.3. 256362.
Family and domain databases
InterPro	IPR005106. Asp/hSer_DH_NAD-bd. IPR001342. Homoserine_dehydrogenase_cat. IPR019811. Homoserine_dehydrogenase_CS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHOM_METJA

Accession

Primary (citable) accession number: Q58997

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)