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Q58992 (GLYA_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
Short name=SHMT
Short name=Serine methylase
EC=2.1.2.1
Gene names
Name:glyA
Ordered Locus Names:MJ1597
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
PRO_0000113713

Regions

Region120 – 1223Substrate binding By similarity

Sites

Binding site301Pyridoxal phosphate By similarity
Binding site501Pyridoxal phosphate By similarity
Binding site521Substrate By similarity
Binding site601Pyridoxal phosphate By similarity
Binding site1711Pyridoxal phosphate By similarity
Binding site1991Pyridoxal phosphate By similarity
Binding site2251Pyridoxal phosphate By similarity
Binding site3631Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58992 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C115CECA4E649C7A

FASTA42948,084
        10         20         30         40         50         60 
MEYSDVPKFI RDVSIKQHEW MRESIKLIAS ENITSLAVRE ACATDFMHRY AEGLPGKRLY 

        70         80         90        100        110        120 
QGCKYIDEVE TLCIELSKEL FKAEHANVQP TSGVVANLAV FFAETKPGDK LMALSVPDGG 

       130        140        150        160        170        180 
HISHWKVSAA GIRGLKVINH PFDPEEMNID ADAMVKKILE EKPKLILFGG SLFPFPHPVA 

       190        200        210        220        230        240 
DAYEAAQEVG AKIAYDGAHV LGLIAGKQFQ DPLREGAEYL MGSTHKTFFG PQGGVILTTK 

       250        260        270        280        290        300 
ENADKIDSHV FPGVVSNHHL HHKAGLAIAL AEMLEFGEAY AKQVIKNAKA LAQALYERGF 

       310        320        330        340        350        360 
NVLCEHKDFT ESHQVIIDIE SSPDIEFSAS ELAKMYEEAN IILNKNLLPW DDVNNSDNPS 

       370        380        390        400        410        420 
GIRLGTQECT RLGMKEKEME EIAEFMKRIA IDKEKPEKVR EDVKEFAKEY STIHYSFDEG 


DGFKYLRFY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB99615.1.
PIRD64499.
RefSeqNP_248606.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58992.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1452505.
GenomeReviewsGene locus MJ1597 in contig L77117_GR.
KEGGmja:MJ_1597.
NMPDRfig|243232.1.peg.1643.
TIGRMJ1597.

Phylogenomic databases

HOGENOMHBG301263.
OMARGMGAKE.
ProtClustDBPRK00011.

Enzyme and pathway databases

BioCycMJAN243232:MJ_1597-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA_METJA
AccessionPrimary (citable) accession number: Q58992
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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