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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.6. 3260.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase
Gene namesi
Name:purC
Ordered Locus Names:MJ1592
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009091 – 242Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST242

Proteomic databases

PRIDEiQ58987.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1592.

Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 8Combined sources4
Beta strandi14 – 16Combined sources3
Beta strandi18 – 24Combined sources7
Beta strandi26 – 34Combined sources9
Beta strandi36 – 40Combined sources5
Turni41 – 44Combined sources4
Beta strandi45 – 48Combined sources4
Helixi52 – 69Combined sources18
Beta strandi74 – 80Combined sources7
Turni81 – 83Combined sources3
Beta strandi84 – 88Combined sources5
Beta strandi90 – 92Combined sources3
Beta strandi94 – 102Combined sources9
Helixi106 – 110Combined sources5
Beta strandi118 – 128Combined sources11
Helixi131 – 133Combined sources3
Helixi140 – 145Combined sources6
Helixi151 – 174Combined sources24
Beta strandi177 – 184Combined sources8
Beta strandi186 – 189Combined sources4
Beta strandi194 – 196Combined sources3
Turni202 – 204Combined sources3
Beta strandi205 – 209Combined sources5
Turni210 – 212Combined sources3
Helixi219 – 222Combined sources4
Helixi228 – 238Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZLX-ray2.20A1-242[»]
2Z02X-ray2.03A/B1-242[»]
ProteinModelPortaliQ58987.
SMRiQ58987.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58987.

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.Curated

Phylogenomic databases

eggNOGiarCOG04421. Archaea.
COG0152. LUCA.
InParanoidiQ58987.
KOiK01923.
OMAiFNAQKRG.
PhylomeDBiQ58987.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKLEEILK KQPLYSGKAK SIYEIDDDKV LIEFRDDITA GNGAKHDVKQ
60 70 80 90 100
GKGYLNALIS SKLFEALEEN GVKTHYIKYI EPRYMIAKKV EIIPIEVIVR
110 120 130 140 150
NIAAGSLCRR YPFEEGKELP FPIVQFDYKN DEYGDPMLNE DIAVALGLAT
160 170 180 190 200
REELNKIKEI ALKVNEVLKK LFDEKGIILV DFKIEIGKDR EGNLLVADEI
210 220 230 240
SPDTMRLWDK ETRDVLDKDV FRKDLGDVIA KYRIVAERLG LL
Length:242
Mass (Da):27,761
Last modified:November 1, 1996 - v1
Checksum:iE72A473335DA3E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99610.1.
PIRiG64498.
RefSeqiWP_010871116.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99610; AAB99610; MJ_1592.
GeneIDi1452500.
KEGGimja:MJ_1592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99610.1.
PIRiG64498.
RefSeqiWP_010871116.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YZLX-ray2.20A1-242[»]
2Z02X-ray2.03A/B1-242[»]
ProteinModelPortaliQ58987.
SMRiQ58987.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1592.

Proteomic databases

PRIDEiQ58987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99610; AAB99610; MJ_1592.
GeneIDi1452500.
KEGGimja:MJ_1592.

Phylogenomic databases

eggNOGiarCOG04421. Archaea.
COG0152. LUCA.
InParanoidiQ58987.
KOiK01923.
OMAiFNAQKRG.
PhylomeDBiQ58987.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BRENDAi6.3.2.6. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58987.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUR7_METJA
AccessioniPrimary (citable) accession number: Q58987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.